The influence of respiratory infections on Henoch-Schönlein purpura in children
Abstract Objective To explore the influence of respiratory infections on the onset of Henoch-Schönlein Purpura (HSP) in children, along with exploring potential underlying mechanisms. Method The present study conducted a statistical analysis on renal involvement indicators in 296 children with HSP w...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-025-10514-4 |
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| author | Bili Wang Wenqing Xiang Zhouyue Zhu Hongqiang Shen |
| author_facet | Bili Wang Wenqing Xiang Zhouyue Zhu Hongqiang Shen |
| author_sort | Bili Wang |
| collection | DOAJ |
| description | Abstract Objective To explore the influence of respiratory infections on the onset of Henoch-Schönlein Purpura (HSP) in children, along with exploring potential underlying mechanisms. Method The present study conducted a statistical analysis on renal involvement indicators in 296 children with HSP who came to the Children’s Hospital of Zhejiang University, as well as the IgA levels in 400 children with respiratory infections and 400 children with HSP. Results Compared with the control group, children with HSP exhibited a significant increase in urine red blood cell count, urine microalbuminuria, and urine protein/creatinine ratio (P < 0.001). The monthly outpatient visits for children with respiratory infections exhibited a similar pattern to those with HSP, demonstrating a heightened prevalence during the autumn and winter. The level of IgA in children with respiratory infections and HSP were significantly higher than those in the control group (P < 0.001). Conclusion HSP can give rise to complications such as renal involvement. There exists a certain correlation between respiratory infections and the occurrence of HSP, which may be attributed to the elevation of IgA induced by respiratory infections. In conclusion, children with HSP should reinforce protective measures during the peak influenza season in order to prevent respiratory infections. |
| format | Article |
| id | doaj-art-0047871bab9a4908a6aae55c2cf3b61f |
| institution | Kabale University |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-0047871bab9a4908a6aae55c2cf3b61f2025-01-26T12:16:53ZengBMCBMC Infectious Diseases1471-23342025-01-012511910.1186/s12879-025-10514-4The influence of respiratory infections on Henoch-Schönlein purpura in childrenBili Wang0Wenqing Xiang1Zhouyue Zhu2Hongqiang Shen3National Clinical Research Center for Child Health, National Children’s Regional Medical Center, the Children’s Hospital, Zhejiang University School of MedicineNational Clinical Research Center for Child Health, National Children’s Regional Medical Center, the Children’s Hospital, Zhejiang University School of MedicineZhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), University School of MedicineNational Clinical Research Center for Child Health, National Children’s Regional Medical Center, the Children’s Hospital, Zhejiang University School of MedicineAbstract Objective To explore the influence of respiratory infections on the onset of Henoch-Schönlein Purpura (HSP) in children, along with exploring potential underlying mechanisms. Method The present study conducted a statistical analysis on renal involvement indicators in 296 children with HSP who came to the Children’s Hospital of Zhejiang University, as well as the IgA levels in 400 children with respiratory infections and 400 children with HSP. Results Compared with the control group, children with HSP exhibited a significant increase in urine red blood cell count, urine microalbuminuria, and urine protein/creatinine ratio (P < 0.001). The monthly outpatient visits for children with respiratory infections exhibited a similar pattern to those with HSP, demonstrating a heightened prevalence during the autumn and winter. The level of IgA in children with respiratory infections and HSP were significantly higher than those in the control group (P < 0.001). Conclusion HSP can give rise to complications such as renal involvement. There exists a certain correlation between respiratory infections and the occurrence of HSP, which may be attributed to the elevation of IgA induced by respiratory infections. In conclusion, children with HSP should reinforce protective measures during the peak influenza season in order to prevent respiratory infections.https://doi.org/10.1186/s12879-025-10514-4Henoch-Schönlein PurpuraRespiratory infectionsRenal involvementIgA |
| spellingShingle | Bili Wang Wenqing Xiang Zhouyue Zhu Hongqiang Shen The influence of respiratory infections on Henoch-Schönlein purpura in children BMC Infectious Diseases Henoch-Schönlein Purpura Respiratory infections Renal involvement IgA |
| title | The influence of respiratory infections on Henoch-Schönlein purpura in children |
| title_full | The influence of respiratory infections on Henoch-Schönlein purpura in children |
| title_fullStr | The influence of respiratory infections on Henoch-Schönlein purpura in children |
| title_full_unstemmed | The influence of respiratory infections on Henoch-Schönlein purpura in children |
| title_short | The influence of respiratory infections on Henoch-Schönlein purpura in children |
| title_sort | influence of respiratory infections on henoch schonlein purpura in children |
| topic | Henoch-Schönlein Purpura Respiratory infections Renal involvement IgA |
| url | https://doi.org/10.1186/s12879-025-10514-4 |
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