Alleviating D-Galactose-Induced Aging in Mice by Modulating Gut-Liver Axis Using <i>Lactiplantibacillus plantarum</i> TY-Y10
Oxidative stress is closely linked to aging. Probiotics, whether viable or heat-inactivated, have shown antioxidant properties; however, their effect and mechanism of action in reducing oxidative stress during aging remains underexplored. This study examined the effects of viable and heat-inactivate...
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MDPI AG
2024-11-01
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| author | Shaoqi Shi Xiaoxia Li Feng Zhang Zhengqiang Jiang Jing Wang Liang Zhao Juan Chen Xi Shu Bing Fang Ping Liu Jingjing He Shaoyang Ge Fuqing Wang Jie Guo Yixuan Li Jie Luo Ran Wang |
| author_facet | Shaoqi Shi Xiaoxia Li Feng Zhang Zhengqiang Jiang Jing Wang Liang Zhao Juan Chen Xi Shu Bing Fang Ping Liu Jingjing He Shaoyang Ge Fuqing Wang Jie Guo Yixuan Li Jie Luo Ran Wang |
| author_sort | Shaoqi Shi |
| collection | DOAJ |
| description | Oxidative stress is closely linked to aging. Probiotics, whether viable or heat-inactivated, have shown antioxidant properties; however, their effect and mechanism of action in reducing oxidative stress during aging remains underexplored. This study examined the effects of viable and heat-inactivated <i>Lactiplantibacillus plantarum</i> TY-Y10 (<i>L. plantarum</i> TY-Y10) on D-galactose (D-gal)-induced aging in mice, aiming to uncover potential anti-aging mechanisms. Mice were induced to age with D-gal injections, then treated with sodium ascorbate (positive control) or varying doses of <i>L. plantarum</i> TY-Y10 for eight weeks. After treatment, oxidative stress markers, gut microbiota, and liver health were analyzed. Results showed that <i>L. plantarum</i> TY-Y10 decreased malondialdehyde (MDA) and inflammatory markers while increasing antioxidant levels (glutathione, superoxide dismutase, catalase and glutathione peroxidase). Liver damage was reduced, and expression of Nrf2 and related antioxidant enzymes improved. Additionally, <i>L. plantarum</i> TY-Y10 enhanced the abundance of short-chain fatty acid-producing bacteria, boosting fecal short-chain fatty acid levels. In short, both viable and heat-inactivated <i>L. plantarum</i> TY-Y10 mitigated oxidative stress in aging mice by modulating gut microbiota and activating liver antioxidant pathways through the gut-liver axis. |
| format | Article |
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| institution | OA Journals |
| issn | 2304-8158 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Foods |
| spelling | doaj-art-003e67d4ee904cbaaaf4bc4f9a74d69f2025-08-20T02:28:05ZengMDPI AGFoods2304-81582024-11-011322361810.3390/foods13223618Alleviating D-Galactose-Induced Aging in Mice by Modulating Gut-Liver Axis Using <i>Lactiplantibacillus plantarum</i> TY-Y10Shaoqi Shi0Xiaoxia Li1Feng Zhang2Zhengqiang Jiang3Jing Wang4Liang Zhao5Juan Chen6Xi Shu7Bing Fang8Ping Liu9Jingjing He10Shaoyang Ge11Fuqing Wang12Jie Guo13Yixuan Li14Jie Luo15Ran Wang16Key Laboratory of Functional Dairy, Department of Nutrition and Health, Co-Constructed by Ministry of Education and Beijing Government, China Agricultural University, Beijing 100190, ChinaKey Laboratory of Functional Dairy, Department of Nutrition and Health, Co-Constructed by Ministry of Education and Beijing Government, China Agricultural University, Beijing 100190, ChinaChongqing Key Laboratory for Industry and Informatization of Probiotic Fermentation Technology in Dairy Products, Chongqing Tianyou Dairy Co., Ltd., Chongqing 401120, ChinaKey Laboratory of Food Bioengineering (China National Light Industry), College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaChongqing Key Laboratory for Industry and Informatization of Probiotic Fermentation Technology in Dairy Products, Chongqing Tianyou Dairy Co., Ltd., Chongqing 401120, ChinaResearch Center for Probiotics, China Agricultural University, Beijing 100083, ChinaKey Laboratory of Functional Dairy, Department of Nutrition and Health, Co-Constructed by Ministry of Education and Beijing Government, China Agricultural University, Beijing 100190, ChinaChongqing Key Laboratory for Industry and Informatization of Probiotic Fermentation Technology in Dairy Products, Chongqing Tianyou Dairy Co., Ltd., Chongqing 401120, ChinaFood Laboratory of Zhongyuan, Luohe 461103, ChinaKey Laboratory of Functional Dairy, Department of Nutrition and Health, Co-Constructed by Ministry of Education and Beijing Government, China Agricultural University, Beijing 100190, ChinaResearch Center for Probiotics, China Agricultural University, Beijing 100083, ChinaHebei Engineering Research Center of Animal Product, Sanhe 065200, ChinaTibet Tianhong Science and Technology Co., Ltd., Lhasa 850000, ChinaResearch Center for Probiotics, China Agricultural University, Beijing 100083, ChinaResearch Center for Probiotics, China Agricultural University, Beijing 100083, ChinaCollege of Food Science and Technology, Hunan Agricultural University, Changsha 410114, ChinaKey Laboratory of Functional Dairy, Department of Nutrition and Health, Co-Constructed by Ministry of Education and Beijing Government, China Agricultural University, Beijing 100190, ChinaOxidative stress is closely linked to aging. Probiotics, whether viable or heat-inactivated, have shown antioxidant properties; however, their effect and mechanism of action in reducing oxidative stress during aging remains underexplored. This study examined the effects of viable and heat-inactivated <i>Lactiplantibacillus plantarum</i> TY-Y10 (<i>L. plantarum</i> TY-Y10) on D-galactose (D-gal)-induced aging in mice, aiming to uncover potential anti-aging mechanisms. Mice were induced to age with D-gal injections, then treated with sodium ascorbate (positive control) or varying doses of <i>L. plantarum</i> TY-Y10 for eight weeks. After treatment, oxidative stress markers, gut microbiota, and liver health were analyzed. Results showed that <i>L. plantarum</i> TY-Y10 decreased malondialdehyde (MDA) and inflammatory markers while increasing antioxidant levels (glutathione, superoxide dismutase, catalase and glutathione peroxidase). Liver damage was reduced, and expression of Nrf2 and related antioxidant enzymes improved. Additionally, <i>L. plantarum</i> TY-Y10 enhanced the abundance of short-chain fatty acid-producing bacteria, boosting fecal short-chain fatty acid levels. In short, both viable and heat-inactivated <i>L. plantarum</i> TY-Y10 mitigated oxidative stress in aging mice by modulating gut microbiota and activating liver antioxidant pathways through the gut-liver axis.https://www.mdpi.com/2304-8158/13/22/3618probioticagingNrf2 signaling pathwaygut microbiotashort-chain fatty acids |
| spellingShingle | Shaoqi Shi Xiaoxia Li Feng Zhang Zhengqiang Jiang Jing Wang Liang Zhao Juan Chen Xi Shu Bing Fang Ping Liu Jingjing He Shaoyang Ge Fuqing Wang Jie Guo Yixuan Li Jie Luo Ran Wang Alleviating D-Galactose-Induced Aging in Mice by Modulating Gut-Liver Axis Using <i>Lactiplantibacillus plantarum</i> TY-Y10 Foods probiotic aging Nrf2 signaling pathway gut microbiota short-chain fatty acids |
| title | Alleviating D-Galactose-Induced Aging in Mice by Modulating Gut-Liver Axis Using <i>Lactiplantibacillus plantarum</i> TY-Y10 |
| title_full | Alleviating D-Galactose-Induced Aging in Mice by Modulating Gut-Liver Axis Using <i>Lactiplantibacillus plantarum</i> TY-Y10 |
| title_fullStr | Alleviating D-Galactose-Induced Aging in Mice by Modulating Gut-Liver Axis Using <i>Lactiplantibacillus plantarum</i> TY-Y10 |
| title_full_unstemmed | Alleviating D-Galactose-Induced Aging in Mice by Modulating Gut-Liver Axis Using <i>Lactiplantibacillus plantarum</i> TY-Y10 |
| title_short | Alleviating D-Galactose-Induced Aging in Mice by Modulating Gut-Liver Axis Using <i>Lactiplantibacillus plantarum</i> TY-Y10 |
| title_sort | alleviating d galactose induced aging in mice by modulating gut liver axis using i lactiplantibacillus plantarum i ty y10 |
| topic | probiotic aging Nrf2 signaling pathway gut microbiota short-chain fatty acids |
| url | https://www.mdpi.com/2304-8158/13/22/3618 |
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