Chlamydophila pneumoniae Infection and Its Role in Neurological Disorders
Chlamydophila pneumoniae is an intracellular pathogen responsible for a number of different acute and chronic infections. The recent deepening of knowledge on the biology and the use of increasingly more sensitive and specific molecular techniques has allowed demonstration of C. pneumoniae in a larg...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2010/273573 |
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| author | Carlo Contini Silva Seraceni Rosario Cultrera Massimiliano Castellazzi Enrico Granieri Enrico Fainardi |
| author_facet | Carlo Contini Silva Seraceni Rosario Cultrera Massimiliano Castellazzi Enrico Granieri Enrico Fainardi |
| author_sort | Carlo Contini |
| collection | DOAJ |
| description | Chlamydophila pneumoniae is an intracellular pathogen responsible for a number of different acute and chronic infections. The recent deepening of knowledge on the biology and the use of increasingly more sensitive and
specific molecular techniques has allowed demonstration of C. pneumoniae in
a large number of persons suffering from different diseases including cardiovascular (atherosclerosis and stroke) and central nervous system (CNS) disorders. Despite this, many important issues remain unanswered with regard to the role that C. pneumoniae may play in initiating atheroma or in the progression of the disease. A growing body of evidence concerns the involvement of this pathogen in chronic neurological disorders and particularly in Alzheimer's disease (AD) and Multiple Sclerosis (MS). Monocytes may traffic C. pneumoniae across the blood-brain-barrier, shed the organism in the
CNS and induce neuroinflammation. The demonstration of C. pneumoniae by
histopathological, molecular and culture techniques in the late-onset AD dementia has suggested a relationship between CNS infection with C. pneumoniae and the AD neuropathogenesis. In particular subsets of MS patients, C. pneumoniae could induce a chronic persistent brain infection acting as a cofactor in the development of the disease. The role of Chlamydia in the pathogenesis of mental or neurobehavioral disorders including schizophrenia and autism is uncertain and fragmentary and will require further
confirmation. |
| format | Article |
| id | doaj-art-003e20a8afee420a99768d3180908f9f |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-003e20a8afee420a99768d3180908f9f2025-02-03T01:00:20ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982010-01-01201010.1155/2010/273573273573Chlamydophila pneumoniae Infection and Its Role in Neurological DisordersCarlo Contini0Silva Seraceni1Rosario Cultrera2Massimiliano Castellazzi3Enrico Granieri4Enrico Fainardi5Section of Infectious Diseases, Department of Clinical and Experimental Medicine, National Institute of Neuroscience and Neuroscience Center, University of Ferrara, Via Fossato di Mortara, 23, 44100 Ferrara, ItalySection of Infectious Diseases, Department of Clinical and Experimental Medicine, National Institute of Neuroscience and Neuroscience Center, University of Ferrara, Via Fossato di Mortara, 23, 44100 Ferrara, ItalySection of Infectious Diseases, Department of Clinical and Experimental Medicine, National Institute of Neuroscience and Neuroscience Center, University of Ferrara, Via Fossato di Mortara, 23, 44100 Ferrara, ItalySection of Neurology, Department of Medical and Surgical Sciences of the Communication and Behaviour, Multiple Sclerosis Center, National Institute of Neuroscience and Neuroscience Center, University of Ferrara, Arcispedale S. Anna, Corso della Giovecca 203, 44100 Ferrara, ItalySection of Neurology, Department of Medical and Surgical Sciences of the Communication and Behaviour, Multiple Sclerosis Center, National Institute of Neuroscience and Neuroscience Center, University of Ferrara, Arcispedale S. Anna, Corso della Giovecca 203, 44100 Ferrara, ItalyNeuroradiology Unit, Department of Neurosciences and Rehabilitation, Azienda Ospedaliera-Universitaria, National Institute of Neuroscience and Neuroscience Center, University of Ferrara, Arcispedale S. Anna, Corso della Giovecca 203, 44100 Ferrara, ItalyChlamydophila pneumoniae is an intracellular pathogen responsible for a number of different acute and chronic infections. The recent deepening of knowledge on the biology and the use of increasingly more sensitive and specific molecular techniques has allowed demonstration of C. pneumoniae in a large number of persons suffering from different diseases including cardiovascular (atherosclerosis and stroke) and central nervous system (CNS) disorders. Despite this, many important issues remain unanswered with regard to the role that C. pneumoniae may play in initiating atheroma or in the progression of the disease. A growing body of evidence concerns the involvement of this pathogen in chronic neurological disorders and particularly in Alzheimer's disease (AD) and Multiple Sclerosis (MS). Monocytes may traffic C. pneumoniae across the blood-brain-barrier, shed the organism in the CNS and induce neuroinflammation. The demonstration of C. pneumoniae by histopathological, molecular and culture techniques in the late-onset AD dementia has suggested a relationship between CNS infection with C. pneumoniae and the AD neuropathogenesis. In particular subsets of MS patients, C. pneumoniae could induce a chronic persistent brain infection acting as a cofactor in the development of the disease. The role of Chlamydia in the pathogenesis of mental or neurobehavioral disorders including schizophrenia and autism is uncertain and fragmentary and will require further confirmation.http://dx.doi.org/10.1155/2010/273573 |
| spellingShingle | Carlo Contini Silva Seraceni Rosario Cultrera Massimiliano Castellazzi Enrico Granieri Enrico Fainardi Chlamydophila pneumoniae Infection and Its Role in Neurological Disorders Interdisciplinary Perspectives on Infectious Diseases |
| title | Chlamydophila pneumoniae Infection and Its Role in Neurological Disorders |
| title_full | Chlamydophila pneumoniae Infection and Its Role in Neurological Disorders |
| title_fullStr | Chlamydophila pneumoniae Infection and Its Role in Neurological Disorders |
| title_full_unstemmed | Chlamydophila pneumoniae Infection and Its Role in Neurological Disorders |
| title_short | Chlamydophila pneumoniae Infection and Its Role in Neurological Disorders |
| title_sort | chlamydophila pneumoniae infection and its role in neurological disorders |
| url | http://dx.doi.org/10.1155/2010/273573 |
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