Epidemiology and Management of Actinic Keratosis in France: A General Population Survey (REAKT)
The objective of this retrospective observational study was to estimate the prevalence of actinic keratosis (AK) in individuals aged ≥ 40 years in France, to describe the characteristics of affected patients, and to describe treatments. A representative panel of 20,000 households with ≥ 1 member age...
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Medical Journals Sweden
2025-01-01
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| Series: | Acta Dermato-Venereologica |
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| Online Access: | https://medicaljournalssweden.se/actadv/article/view/42372 |
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| author | Brigitte Dréno Pierre Lévy Gregory Caillet Chantal Touboul Jean-Michel Joubert Jean-Michel Amici |
| author_facet | Brigitte Dréno Pierre Lévy Gregory Caillet Chantal Touboul Jean-Michel Joubert Jean-Michel Amici |
| author_sort | Brigitte Dréno |
| collection | DOAJ |
| description | The objective of this retrospective observational study was to estimate the prevalence of actinic keratosis (AK) in individuals aged ≥ 40 years in France, to describe the characteristics of affected patients, and to describe treatments. A representative panel of 20,000 households with ≥ 1 member aged ≥ 40 years were invited to participate. Participants who reported AK lesions diagnosed by a physician were eligible. The study questionnaire collected data on demographics, lesion characteristics, Fitzpatrick phototype, diagnosis, and treatments. In total, 15,246 questionnaires (78.5%) were returned and 639 responders were eligible. The adjusted prevalence of AK was 4.03% (95% CI: 3.73–4.35). Prevalence is probably underestimated due to data collection by self-report and low awareness of AK. 177 participants (27.7%) were aged < 65 years. AK was diagnosed by a dermatologist for 521 participants (81.6%). Some 200 participants (31.3%) had no lesions at the time of the survey and 243 (37.9%) had never been treated; 312 participants (78.6%) were prescribed physical treatment, principally cryotherapy; and 125 (31.5%) were prescribed topical treatment, principally 5-fluorouracil or imiquimod. In conclusion, improving diagnosis of AK in everyday clinical practice is important to ensure that all individuals with AK are treated optimally and encouraged to take sun protection measures to prevent progression to SCC.
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| format | Article |
| id | doaj-art-00208c04fe0c4433b3c4c19354979fcc |
| institution | Kabale University |
| issn | 0001-5555 1651-2057 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Medical Journals Sweden |
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| series | Acta Dermato-Venereologica |
| spelling | doaj-art-00208c04fe0c4433b3c4c19354979fcc2025-01-26T10:08:53ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572025-01-0110510.2340/actadv.v105.42372Epidemiology and Management of Actinic Keratosis in France: A General Population Survey (REAKT)Brigitte Dréno0https://orcid.org/0000-0001-5574-5825Pierre Lévy1https://orcid.org/0000-0001-7565-2255Gregory Caillet2Chantal Touboul3https://orcid.org/0000-0002-7843-5464Jean-Michel Joubert4Jean-Michel Amici5Nantes University, INSERM, CNRS, Immunology and New Concepts in Immunotherapy, UMR 1302/EMR6001, Nantes, FranceParis-Dauphine University, PSL University, LEDA[LEGOS], Paris, FranceMedical Affairs Department, Almirall SAS, Paris, FranceCerner Enviza France, Paris, FranceGovernment Affairs Department, Almirall SAS, Paris, FranceDepartment of Dermatology, Saint-André Hospital, Bordeaux University Hospital, Bordeaux, FranceThe objective of this retrospective observational study was to estimate the prevalence of actinic keratosis (AK) in individuals aged ≥ 40 years in France, to describe the characteristics of affected patients, and to describe treatments. A representative panel of 20,000 households with ≥ 1 member aged ≥ 40 years were invited to participate. Participants who reported AK lesions diagnosed by a physician were eligible. The study questionnaire collected data on demographics, lesion characteristics, Fitzpatrick phototype, diagnosis, and treatments. In total, 15,246 questionnaires (78.5%) were returned and 639 responders were eligible. The adjusted prevalence of AK was 4.03% (95% CI: 3.73–4.35). Prevalence is probably underestimated due to data collection by self-report and low awareness of AK. 177 participants (27.7%) were aged < 65 years. AK was diagnosed by a dermatologist for 521 participants (81.6%). Some 200 participants (31.3%) had no lesions at the time of the survey and 243 (37.9%) had never been treated; 312 participants (78.6%) were prescribed physical treatment, principally cryotherapy; and 125 (31.5%) were prescribed topical treatment, principally 5-fluorouracil or imiquimod. In conclusion, improving diagnosis of AK in everyday clinical practice is important to ensure that all individuals with AK are treated optimally and encouraged to take sun protection measures to prevent progression to SCC. https://medicaljournalssweden.se/actadv/article/view/42372Actinic keratosisEpidemiologyDisease managementSquamous cell carcinomasurveys and questionnaires |
| spellingShingle | Brigitte Dréno Pierre Lévy Gregory Caillet Chantal Touboul Jean-Michel Joubert Jean-Michel Amici Epidemiology and Management of Actinic Keratosis in France: A General Population Survey (REAKT) Acta Dermato-Venereologica Actinic keratosis Epidemiology Disease management Squamous cell carcinoma surveys and questionnaires |
| title | Epidemiology and Management of Actinic Keratosis in France: A General Population Survey (REAKT) |
| title_full | Epidemiology and Management of Actinic Keratosis in France: A General Population Survey (REAKT) |
| title_fullStr | Epidemiology and Management of Actinic Keratosis in France: A General Population Survey (REAKT) |
| title_full_unstemmed | Epidemiology and Management of Actinic Keratosis in France: A General Population Survey (REAKT) |
| title_short | Epidemiology and Management of Actinic Keratosis in France: A General Population Survey (REAKT) |
| title_sort | epidemiology and management of actinic keratosis in france a general population survey reakt |
| topic | Actinic keratosis Epidemiology Disease management Squamous cell carcinoma surveys and questionnaires |
| url | https://medicaljournalssweden.se/actadv/article/view/42372 |
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