Hormonal Influences on ADC Values in Breast Tissues: A Scoping Review of DWI in Pre- and Post-menopausal Women [version 3; peer review: 2 approved]
Background Breast cancer remains a significant global health concern, with early diagnosis and risk factor identification crucial for improving outcomes. Diffusion-Weighted Imaging (DWI) and Apparent Diffusion Coefficient (ADC) measurements have emerged as promising tools in breast cancer diagnostic...
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2025-01-01
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| author | Neil Barnes Abraham Abhimanyu Pradhan Suresh Sukumar Sneha Ravichandran Winniecia Dkhar Rajagopal Kadavigere |
| author_facet | Neil Barnes Abraham Abhimanyu Pradhan Suresh Sukumar Sneha Ravichandran Winniecia Dkhar Rajagopal Kadavigere |
| author_sort | Neil Barnes Abraham |
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| description | Background Breast cancer remains a significant global health concern, with early diagnosis and risk factor identification crucial for improving outcomes. Diffusion-Weighted Imaging (DWI) and Apparent Diffusion Coefficient (ADC) measurements have emerged as promising tools in breast cancer diagnostics. However, the influence of hormonal status on these measurements remains unclear. Objective This scoping review aims to synthesize current evidence on how hormonal changes in pre- and post-menopausal women influence ADC values of benign, malignant, and fibroglandular breast tissues. Method Following the Arksey and O’Malley framework, we conducted a comprehensive search of Scopus, Embase, and PubMed databases for relevant studies published between January 2000 and 2021. Inclusion criteria encompassed 1.5 Tesla MRI studies reporting ADC values in female subjects, considering menopausal status. Results Six studies meeting the inclusion criteria, involving 612 patients, were analyzed. Findings suggest that menopausal status may influence ADC values, with postmenopausal women generally showing lower ADC values in both normal fibroglandular tissue and breast lesions. The impact of menstrual cycle phases on ADC values was less consistent across studies. Conclusions This review highlights the potential influence of hormonal status on ADC values in breast tissues. While DWI with ADC mapping shows promise as a reliable diagnostic tool across different hormonal states, further research is needed to fully understand and account for hormonal influences on ADC measurements. Future studies should focus on longitudinal designs, standardization of DWI protocols, and integration of hormonal status information into breast cancer risk assessment models. |
| format | Article |
| id | doaj-art-0014f11477a148cfb8e157bd2734f298 |
| institution | Kabale University |
| issn | 2046-1402 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
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| spelling | doaj-art-0014f11477a148cfb8e157bd2734f2982025-01-28T01:00:01ZengF1000 Research LtdF1000Research2046-14022025-01-0113176915Hormonal Influences on ADC Values in Breast Tissues: A Scoping Review of DWI in Pre- and Post-menopausal Women [version 3; peer review: 2 approved]Neil Barnes Abraham0https://orcid.org/0000-0001-5963-3230Abhimanyu Pradhan1Suresh Sukumar2https://orcid.org/0000-0001-9345-9790Sneha Ravichandran3https://orcid.org/0000-0002-4421-038XWinniecia Dkhar4https://orcid.org/0000-0001-5963-3230Rajagopal Kadavigere5https://orcid.org/0000-0003-3486-8740Medical Imaging Technology, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, IndiaMedical Imaging Technology, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, IndiaMedical Imaging Technology, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, IndiaMedical Imaging Technology, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, IndiaMedical Imaging Technology, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, IndiaRadiodiagnosis and Imaging, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, IndiaBackground Breast cancer remains a significant global health concern, with early diagnosis and risk factor identification crucial for improving outcomes. Diffusion-Weighted Imaging (DWI) and Apparent Diffusion Coefficient (ADC) measurements have emerged as promising tools in breast cancer diagnostics. However, the influence of hormonal status on these measurements remains unclear. Objective This scoping review aims to synthesize current evidence on how hormonal changes in pre- and post-menopausal women influence ADC values of benign, malignant, and fibroglandular breast tissues. Method Following the Arksey and O’Malley framework, we conducted a comprehensive search of Scopus, Embase, and PubMed databases for relevant studies published between January 2000 and 2021. Inclusion criteria encompassed 1.5 Tesla MRI studies reporting ADC values in female subjects, considering menopausal status. Results Six studies meeting the inclusion criteria, involving 612 patients, were analyzed. Findings suggest that menopausal status may influence ADC values, with postmenopausal women generally showing lower ADC values in both normal fibroglandular tissue and breast lesions. The impact of menstrual cycle phases on ADC values was less consistent across studies. Conclusions This review highlights the potential influence of hormonal status on ADC values in breast tissues. While DWI with ADC mapping shows promise as a reliable diagnostic tool across different hormonal states, further research is needed to fully understand and account for hormonal influences on ADC measurements. Future studies should focus on longitudinal designs, standardization of DWI protocols, and integration of hormonal status information into breast cancer risk assessment models.https://f1000research.com/articles/13-857/v3Breast cancer Diffusion-Weighted Imaging Apparent Diffusion Coefficient hormonal influence menopause scoping revieweng |
| spellingShingle | Neil Barnes Abraham Abhimanyu Pradhan Suresh Sukumar Sneha Ravichandran Winniecia Dkhar Rajagopal Kadavigere Hormonal Influences on ADC Values in Breast Tissues: A Scoping Review of DWI in Pre- and Post-menopausal Women [version 3; peer review: 2 approved] F1000Research Breast cancer Diffusion-Weighted Imaging Apparent Diffusion Coefficient hormonal influence menopause scoping review eng |
| title | Hormonal Influences on ADC Values in Breast Tissues: A Scoping Review of DWI in Pre- and Post-menopausal Women [version 3; peer review: 2 approved] |
| title_full | Hormonal Influences on ADC Values in Breast Tissues: A Scoping Review of DWI in Pre- and Post-menopausal Women [version 3; peer review: 2 approved] |
| title_fullStr | Hormonal Influences on ADC Values in Breast Tissues: A Scoping Review of DWI in Pre- and Post-menopausal Women [version 3; peer review: 2 approved] |
| title_full_unstemmed | Hormonal Influences on ADC Values in Breast Tissues: A Scoping Review of DWI in Pre- and Post-menopausal Women [version 3; peer review: 2 approved] |
| title_short | Hormonal Influences on ADC Values in Breast Tissues: A Scoping Review of DWI in Pre- and Post-menopausal Women [version 3; peer review: 2 approved] |
| title_sort | hormonal influences on adc values in breast tissues a scoping review of dwi in pre and post menopausal women version 3 peer review 2 approved |
| topic | Breast cancer Diffusion-Weighted Imaging Apparent Diffusion Coefficient hormonal influence menopause scoping review eng |
| url | https://f1000research.com/articles/13-857/v3 |
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