Antibacterial activity of selenium nanoparticles/copper oxide (SeNPs/CuO) nanocomposite against some multi-drug resistant clinical pathogens
Abstract Background Recent advances in nanomedicine have derived novel prospects for development of various bioactive nanoparticles and nanocomposites with significant antibacterial and antifungal properties. This study aims to investigate some characteristics of the novel Se-NPs/Cu2O nanocomposite...
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2025-01-01
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| Series: | BMC Microbiology |
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| Online Access: | https://doi.org/10.1186/s12866-025-03743-9 |
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| author | Ahmed Morad Asaad Sara A. Saied Mohammad M. Torayah N. I. Abu-Elsaad Samah Mohammed Awad. |
| author_facet | Ahmed Morad Asaad Sara A. Saied Mohammad M. Torayah N. I. Abu-Elsaad Samah Mohammed Awad. |
| author_sort | Ahmed Morad Asaad |
| collection | DOAJ |
| description | Abstract Background Recent advances in nanomedicine have derived novel prospects for development of various bioactive nanoparticles and nanocomposites with significant antibacterial and antifungal properties. This study aims to investigate some characteristics of the novel Se-NPs/Cu2O nanocomposite such as morphological, physicochemical, and optical properties, as well as to assess the antibacterial activity of this fabricated composite in different concentrations against some MDR Gram-positive and Gram-negative clinical bacterial isolates. Methods The Se-NPs/Cu2O nanocomposite was fabricated using the chemical deposition method. The fabricated nanocomposite was fully characterized by X-Ray diffraction analysis (XRD), fourier transforms infrared spectroscopy (FTIR), and transmission electron microscope (TEM). The antimicrobial activity of Se-NPs/Cu2O was investigated using the standard broth microdilution method. The fabricated Se-NPs/Cu2O nanocomposites were detected as stable and highly crystallized nanospheres with an average size of 98.6 nm. Results The Se-NPs/Cu2O nanocomposite showed a potent antimicrobial activity with MIC values ranged from 6.25 to 12.5 µg/ml for Gram-positive isolates, and 25 to 50 µg/ml for gram-negative isolates. The bactericidal activity was higher for gram-negative isolates with MBC/MIC ratios of 1–2 µg/ml for gram-negative, versus 8 µg/ml for gram positive pathogens. Conclusion These findings would support further research in development of a novel Se-NPs/Cu2O nanocomposite as a promising alternative therapeutic option for improving the quality of patients’ management. |
| format | Article |
| id | doaj-art-000ac38dfacd4b4a90623dcc53eeef26 |
| institution | Kabale University |
| issn | 1471-2180 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Microbiology |
| spelling | doaj-art-000ac38dfacd4b4a90623dcc53eeef262025-01-26T12:17:57ZengBMCBMC Microbiology1471-21802025-01-012511710.1186/s12866-025-03743-9Antibacterial activity of selenium nanoparticles/copper oxide (SeNPs/CuO) nanocomposite against some multi-drug resistant clinical pathogensAhmed Morad Asaad0Sara A. Saied1Mohammad M. Torayah2N. I. Abu-Elsaad3Samah Mohammed Awad.4Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig UniversityDepartment of Clinical Pathology, National Liver Institute, Menoufia UniversityDepartment of Anaesthesia and Intensive care, critical care unit, Faculty of Medicine, Menoufia UniversityPhysics Department, Faculty of Science, Zagazig UniversityClinical microbiology and immunology department, National liver institute, Menoufia UniversityAbstract Background Recent advances in nanomedicine have derived novel prospects for development of various bioactive nanoparticles and nanocomposites with significant antibacterial and antifungal properties. This study aims to investigate some characteristics of the novel Se-NPs/Cu2O nanocomposite such as morphological, physicochemical, and optical properties, as well as to assess the antibacterial activity of this fabricated composite in different concentrations against some MDR Gram-positive and Gram-negative clinical bacterial isolates. Methods The Se-NPs/Cu2O nanocomposite was fabricated using the chemical deposition method. The fabricated nanocomposite was fully characterized by X-Ray diffraction analysis (XRD), fourier transforms infrared spectroscopy (FTIR), and transmission electron microscope (TEM). The antimicrobial activity of Se-NPs/Cu2O was investigated using the standard broth microdilution method. The fabricated Se-NPs/Cu2O nanocomposites were detected as stable and highly crystallized nanospheres with an average size of 98.6 nm. Results The Se-NPs/Cu2O nanocomposite showed a potent antimicrobial activity with MIC values ranged from 6.25 to 12.5 µg/ml for Gram-positive isolates, and 25 to 50 µg/ml for gram-negative isolates. The bactericidal activity was higher for gram-negative isolates with MBC/MIC ratios of 1–2 µg/ml for gram-negative, versus 8 µg/ml for gram positive pathogens. Conclusion These findings would support further research in development of a novel Se-NPs/Cu2O nanocomposite as a promising alternative therapeutic option for improving the quality of patients’ management.https://doi.org/10.1186/s12866-025-03743-9Selenium nanoparticlesCopper oxide nanoparticleMulti-drug resistant bacteriaNanomedicine |
| spellingShingle | Ahmed Morad Asaad Sara A. Saied Mohammad M. Torayah N. I. Abu-Elsaad Samah Mohammed Awad. Antibacterial activity of selenium nanoparticles/copper oxide (SeNPs/CuO) nanocomposite against some multi-drug resistant clinical pathogens BMC Microbiology Selenium nanoparticles Copper oxide nanoparticle Multi-drug resistant bacteria Nanomedicine |
| title | Antibacterial activity of selenium nanoparticles/copper oxide (SeNPs/CuO) nanocomposite against some multi-drug resistant clinical pathogens |
| title_full | Antibacterial activity of selenium nanoparticles/copper oxide (SeNPs/CuO) nanocomposite against some multi-drug resistant clinical pathogens |
| title_fullStr | Antibacterial activity of selenium nanoparticles/copper oxide (SeNPs/CuO) nanocomposite against some multi-drug resistant clinical pathogens |
| title_full_unstemmed | Antibacterial activity of selenium nanoparticles/copper oxide (SeNPs/CuO) nanocomposite against some multi-drug resistant clinical pathogens |
| title_short | Antibacterial activity of selenium nanoparticles/copper oxide (SeNPs/CuO) nanocomposite against some multi-drug resistant clinical pathogens |
| title_sort | antibacterial activity of selenium nanoparticles copper oxide senps cuo nanocomposite against some multi drug resistant clinical pathogens |
| topic | Selenium nanoparticles Copper oxide nanoparticle Multi-drug resistant bacteria Nanomedicine |
| url | https://doi.org/10.1186/s12866-025-03743-9 |
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