Unveiling the immunomodulatory dance: endothelial cells’ function and their role in non-small cell lung cancer
Abstract The dynamic interactions between tumor endothelial cells (TECs) and the immune microenvironment play a critical role in the progression of non-small cell lung cancer (NSCLC). In general, endothelial cells exhibit diverse immunomodulatory properties, influencing immune cell recruitment, anti...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Molecular Cancer |
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| Online Access: | https://doi.org/10.1186/s12943-024-02221-6 |
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| _version_ | 1832594947575906304 |
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| author | Sophia Daum Lilith Decristoforo Mira Mousa Stefan Salcher Christina Plattner Baharak Hosseinkhani Zlatko Trajanoski Dominik Wolf Peter Carmeliet Andreas Pircher |
| author_facet | Sophia Daum Lilith Decristoforo Mira Mousa Stefan Salcher Christina Plattner Baharak Hosseinkhani Zlatko Trajanoski Dominik Wolf Peter Carmeliet Andreas Pircher |
| author_sort | Sophia Daum |
| collection | DOAJ |
| description | Abstract The dynamic interactions between tumor endothelial cells (TECs) and the immune microenvironment play a critical role in the progression of non-small cell lung cancer (NSCLC). In general, endothelial cells exhibit diverse immunomodulatory properties, influencing immune cell recruitment, antigen presentation, and regulation of immune checkpoint expression. Understanding the multifaceted roles of TECs as well as assigning specific functional hallmarks to various TEC phenotypes offer new avenues for targeted development of therapeutic interventions, particularly in the context of advanced immunotherapy and anti-angiogenic treatments. This review provides insights into the complex interplay between TECs and the immune system in NSCLC including discussion of potential optimized therapeutic opportunities. |
| format | Article |
| id | doaj-art-0003ff8acb6641b598cea50d3495a93e |
| institution | Kabale University |
| issn | 1476-4598 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj-art-0003ff8acb6641b598cea50d3495a93e2025-01-19T12:12:40ZengBMCMolecular Cancer1476-45982025-01-0124111810.1186/s12943-024-02221-6Unveiling the immunomodulatory dance: endothelial cells’ function and their role in non-small cell lung cancerSophia Daum0Lilith Decristoforo1Mira Mousa2Stefan Salcher3Christina Plattner4Baharak Hosseinkhani5Zlatko Trajanoski6Dominik Wolf7Peter Carmeliet8Andreas Pircher9Internal Medicine 5, Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Tyrolean Cancer Research Institute (TKFI), Medical University InnsbruckInternal Medicine 5, Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Tyrolean Cancer Research Institute (TKFI), Medical University InnsbruckCenter for Biotechnology, Khalifa University of Science and TechnologyInternal Medicine 5, Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Tyrolean Cancer Research Institute (TKFI), Medical University InnsbruckInstitute of Bioinformatics, Biocenter Medical University InnsbruckLaboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), VIB Center for Cancer Biology, KU Leuven, VIBInstitute of Bioinformatics, Biocenter Medical University InnsbruckInternal Medicine 5, Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Tyrolean Cancer Research Institute (TKFI), Medical University InnsbruckCenter for Biotechnology, Khalifa University of Science and TechnologyInternal Medicine 5, Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Tyrolean Cancer Research Institute (TKFI), Medical University InnsbruckAbstract The dynamic interactions between tumor endothelial cells (TECs) and the immune microenvironment play a critical role in the progression of non-small cell lung cancer (NSCLC). In general, endothelial cells exhibit diverse immunomodulatory properties, influencing immune cell recruitment, antigen presentation, and regulation of immune checkpoint expression. Understanding the multifaceted roles of TECs as well as assigning specific functional hallmarks to various TEC phenotypes offer new avenues for targeted development of therapeutic interventions, particularly in the context of advanced immunotherapy and anti-angiogenic treatments. This review provides insights into the complex interplay between TECs and the immune system in NSCLC including discussion of potential optimized therapeutic opportunities.https://doi.org/10.1186/s12943-024-02221-6NSCLCEndotheliumTECLungAngiogenesisImmune response |
| spellingShingle | Sophia Daum Lilith Decristoforo Mira Mousa Stefan Salcher Christina Plattner Baharak Hosseinkhani Zlatko Trajanoski Dominik Wolf Peter Carmeliet Andreas Pircher Unveiling the immunomodulatory dance: endothelial cells’ function and their role in non-small cell lung cancer Molecular Cancer NSCLC Endothelium TEC Lung Angiogenesis Immune response |
| title | Unveiling the immunomodulatory dance: endothelial cells’ function and their role in non-small cell lung cancer |
| title_full | Unveiling the immunomodulatory dance: endothelial cells’ function and their role in non-small cell lung cancer |
| title_fullStr | Unveiling the immunomodulatory dance: endothelial cells’ function and their role in non-small cell lung cancer |
| title_full_unstemmed | Unveiling the immunomodulatory dance: endothelial cells’ function and their role in non-small cell lung cancer |
| title_short | Unveiling the immunomodulatory dance: endothelial cells’ function and their role in non-small cell lung cancer |
| title_sort | unveiling the immunomodulatory dance endothelial cells function and their role in non small cell lung cancer |
| topic | NSCLC Endothelium TEC Lung Angiogenesis Immune response |
| url | https://doi.org/10.1186/s12943-024-02221-6 |
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