Timothy A. Springer
Timothy "Tim" A. Springer (born February 23, 1948) is an American
biochemist,
immunologist, and
biophysicist known for his foundational work on protein allostery, cell adhesion, vasculature, and immune regulation. He is the Latham Family
Professor at
Harvard Medical School in the Departments of Pediatrics and of
Biological Chemistry and Molecular
Pharmacology, and a faculty member in the Program in Cellular and
Molecular Medicine and Division of Hematology at the
Boston Children’s Hospital (BCH). Springer is best known for discovering the first
integrins,
LFA-1, and
intercellular adhesion molecules (ICAMs), and for elucidating how these
cell adhesion molecules function in the
immune system. In recent years, his laboratory has expanded to structural and mechanobiological studies of
integrins,
transforming growth factor β (TGF-β), and synthetic hydrogels designed to enhance
organoid fidelity for regenerative medicine and drug discovery.
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