Thumbi Ndung'u
'''Thumbi Ndung'u''' is a Kenyan HIV/AIDS researcher. He is the Director for Basic and Translational Science and a [https://www.mpiib-berlin.mpg.de/2285/en Max Planck Research Group] Leader at the [https://www.ahri.org/ Africa Health Research Institute (AHRI)] in KwaZulu-Natal, South Africa. He is Professor of Infectious Diseases in the [https://www.ucl.ac.uk/infection-immunity/ Division of Immunity and Infection, University College London]. He is Professor and [https://www.daitzgateway.org/ Victor Daitz] Chair in HIV/TB Research and Scientific Director of the [http://hpp.ukzn.ac.za/HIVPathogenesisProgramme.aspx HIV Pathogenesis Programme (HPP)] at the [https://chs.ukzn.ac.za/ Nelson R. Mandela School of Medicine], University of KwaZulu-Natal. He holds the South African Research Chair in Systems Biology of HIV/AIDS. He is an adjunct professor of Immunology and Infectious Diseases at the Harvard T.H. Chan School of Public Health. He is the Programme Director of the [https://www.santheafrica.org/ Sub-Saharan African Network for TB/HIV Research Excellence (SANTHE)], a research and capacity building initiative led by Africa Health Research Institute, and funded by the African Academy of Sciences and the Wellcome Trust.Ndung'u attended Gathugu Primary School in Kiambu, Kenya and Nyeri High School, Nyeri, Kenya. He graduated with a Bachelor of Veterinary Medicine degree from the University of Nairobi, Kenya, and obtained a PhD in Biological Sciences in Public Health from Harvard University, United States. As a graduate student, he worked with Max Essex at Harvard. He was also a Postdoctoral Fellow in Virology at Harvard Medical School. He is a member of the Academy of Science of South Africa (ASSAf) and a fellow of the African Academy of Sciences (AAS). He has been a member of the External Advisory Board of the HIV Vaccine Trials Network (HVTN), a member of the Scientific Advisory Committee of the [http://www.chil.org.za/ Cape Town HVTN Immunology Laboratory] (CHIL), a member of the Scientific Advisory Panel of the [https://www.prf.ac.za/ Poliomyelitis Research Foundation] and a member of the advisory board of the Global Health and Vaccination Research Programme (GLOBVAC), The Research Council of Norway. He was co-chair of the Young and Early Career Investigators Committee (YECIC) of the Global HIV Vaccine Enterprise from 2008 to 2010 that worked on the Enterprise's five-year strategic plan.
Ndung'u was the first scientist to clone infectious HIV subtype C and has received numerous awards for his scientific and scholarly contributions. The awards include:
* Jun 2001 - [https://www.hsph.harvard.edu/graduation/awards/edgar-haber-award/ Edgar Haber Award] (Harvard University) in recognition of "outstanding, original and creative thesis work that makes a fundamental contribution to our understanding of a biological problem important to public health." * Feb 2007 - [http://research.ukzn.ac.za/ResearchFunding/Internal-Funding-and-Awards/ Vice-Chancellor's Research Award], University of KwaZulu-Natal in recognition of "exceptional research and research related scholarly activities." * Jan 2012 - Howard Hughes Medical Institute's International Early Career Scientist Award. * Oct 2017 - South African Medical Research Council [https://www.samrc.ac.za/content/samrc-scientific-merit-awards Gold Scientific Achievement Award]. Gold medals are awarded to established senior scientists who have made seminal scientific contributions that have impacted on the health of people. * Nov 2018 - Research Excellence Award at the South African Health Excellence Awards. The award ceremony celebrated excellence in healthcare by identifying leaders in medicine who have contributed to research, teaching and advancement of medicine in South Africa.
His research interests are host-pathogen interactions, particularly immune mechanisms of HIV and TB control. He has co-authored more than 200 manuscripts in peer-reviewed journals. He has made seminal contributions on our understanding of how virus-host interactions lead to immune-mediated mechanisms of HIV control, which has implications for immune-based prophylactic and therapeutic strategies against the virus. He has received grant funding from the South African National Research Foundation, the South African Medical Research Council, the Bill and Melinda Gates Foundation, the National Institutes of Health, the Howard Hughes Medical Institute, the European Union, the African Academy of Sciences and the Wellcome Trust among others. He is leading a multidisciplinary team of researchers working in the fields of HIV and TB [https://www.nature.com/subjects/immunopathogenesis immunopathogenesis], vaccine development and immune-based HIV functional cure strategies. He has special interest in capacity building for biomedical research in Africa. Provided by Wikipedia
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Antiretroviral therapy initiated during acute infection in women with HIV-1 clade C reduces anti-Tat antibody production and lowers CD8+ T cell activation by Thandeka I. Kubheka, Kewreshini Naidoo, Kavidha Reddy, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Nompumelelo P. Mkhwanazi
Published 2025-06-01Get full text
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‘With this study, we have hope that something is coming’: community members’ perceptions of HIV cure-related research in Durban, South Africa – a qualitative focus group study... by Karine Dubé, Deli Mthimkhulu, Wiseman Ngcobo, Deborah Mindry, Luyanda Maphalala, Vanessa Pillay, Whitney Tran, Ana Korolkova, Thumbi Ndung’u, Krista Dong
Published 2023-12-01Get full text
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Differences in HIV-1 reservoir size, landscape characteristics, and decay dynamics in acute and chronic treated HIV-1 Clade C infection by Kavidha Reddy, Guinevere Q Lee, Nicole Reddy, Tatenda JB Chikowore, Kathy Baisley, Krista L Dong, Bruce D Walker, Xu G Yu, Mathias Lichterfeld, Thumbi Ndung'u
Published 2025-02-01Get full text
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HIV-1 Gag-protease-driven replicative capacity influences T-cell metabolism, cytokine induction, and viral cell-to-cell spread by Omolara O. Baiyegunhi, Kensane Mthembu, Ann-Kathrin Reuschl, Doty Ojwach, Omotayo Farinre, Murunwa Maimela, Sheila Balinda, Matt Price, Madeleine J. Bunders, Marcus Altfeld, Clare Jolly, Jaclyn Mann, Thumbi Ndung’u
Published 2025-04-01Get full text
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Low levels of peripheral CD161++CD8+ mucosal associated invariant T (MAIT) cells are found in HIV and HIV/TB co-infection. by Emily B Wong, Ngomu Akeem Akilimali, Pamla Govender, Zuri A Sullivan, Cormac Cosgrove, Mona Pillay, David M Lewinsohn, William R Bishai, Bruce D Walker, Thumbi Ndung'u, Paul Klenerman, Victoria O Kasprowicz
Published 2013-01-01Get full text
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Sex Differences in Antiretroviral Therapy Initiation in Pediatric HIV Infection. by Masahiko Mori, Emily Adland, Paolo Paioni, Alice Swordy, Luisa Mori, Leana Laker, Maximilian Muenchhoff, Philippa C Matthews, Gareth Tudor-Williams, Nora Lavandier, Anriette van Zyl, Jacob Hurst, Bruce D Walker, Thumbi Ndung'u, Andrew Prendergast, Philip Goulder, Pieter Jooste
Published 2015-01-01Get full text
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Prevalence and Characteristics of Hepatitis B Virus (HBV) Coinfection among HIV-Positive Women in South Africa and Botswana. by Philippa C Matthews, Apostolos Beloukas, Amna Malik, Jonathan M Carlson, Pieter Jooste, Anthony Ogwu, Roger Shapiro, Lynn Riddell, Fabian Chen, Graz Luzzi, Manjeetha Jaggernath, Gerald Jesuthasan, Katie Jeffery, Thumbi Ndung'u, Philip J R Goulder, Anna Maria Geretti, Paul Klenerman
Published 2015-01-01Get full text
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Nef-specific CD8+ T cell responses contribute to HIV-1 immune control. by Emily Adland, Jonathan M Carlson, Paolo Paioni, Henrik Kløverpris, Roger Shapiro, Anthony Ogwu, Lynn Riddell, Graz Luzzi, Fabian Chen, Thambiah Balachandran, David Heckerman, Anette Stryhn, Anne Edwards, Thumbi Ndung'u, Bruce D Walker, Søren Buus, Philip Goulder, Philippa C Matthews
Published 2013-01-01Get full text
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‘It is scary to pause treatment’: perspectives on HIV cure-related research and analytical treatment interruptions from women diagnosed during acute HIV in Durban, South Africa: So... by Deli Mthimkhulu, Krista L. Dong, Mzwakhe Wiseman Ngcobo, Deborah Mindry, Ayanda Zulu, Ntombifuthi Langa, Luyanda Maphalala, Vanessa Pillay, Maud Mthembu, Annie Miall, Whitney Tran, Ana Dillen, Fang Wan, Ali Ahmed, Jamila K. Stockman, Maryam Hussain, Thumbi Ndung’u, Karine Dubé
Published 2025-12-01Get full text
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Distinct neutralization sensitivity between adult and infant transmitted/founder HIV-1 subtype C viruses to broadly neutralizing monoclonal antibodies. by Bongiwe Ndlovu, Kamini Gounder, Nelisiwe Zikhali, Lanish Singh, Ntokozo Ntshangase, Nombali Gumede, Jane Millar, Rebecca T van Dorsten, Nicholas E Grayson, David Bonsall, Sandra E Chaudron, Jennifer Mabuka, Krista L Dong, Bruce D Walker, Penny L Moore, Philip J R Goulder, Thumbi Ndung'u
Published 2025-06-01Get full text
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Co-operative additive effects between HLA alleles in control of HIV-1. by Philippa C Matthews, Jennifer Listgarten, Jonathan M Carlson, Rebecca Payne, Kuan-Hsiang Gary Huang, John Frater, Dominique Goedhals, Dewald Steyn, Cloete van Vuuren, Paolo Paioni, Pieter Jooste, Anthony Ogwu, Roger Shapiro, Zenele Mncube, Thumbi Ndung'u, Bruce D Walker, David Heckerman, Philip J R Goulder
Published 2012-01-01Get full text
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A molecular assay for sensitive detection of pathogen-specific T-cells. by Victoria O Kasprowicz, Jessica E Mitchell, Shivan Chetty, Pamla Govender, Kuan-Hsiang Gary Huang, Helen A Fletcher, Daniel P Webster, Sebastian Brown, Anne Kasmar, Kerry Millington, Cheryl L Day, Nompumelelo Mkhwanazi, Cheryl McClurg, Fundisiwe Chonco, Ajit Lalvani, Bruce D Walker, Thumbi Ndung'u, Paul Klenerman
Published 2011-01-01Get full text
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Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutations. by Kuan-Hsiang Gary Huang, Dominique Goedhals, Jonathan M Carlson, Mark A Brockman, Swati Mishra, Zabrina L Brumme, Stephen Hickling, Christopher S W Tang, Toshiyuki Miura, Chris Seebregts, David Heckerman, Thumbi Ndung'u, Bruce Walker, Paul Klenerman, Dewald Steyn, Philip Goulder, Rodney Phillips, Bloemfontein-Oxford Collaborative Group, Cloete van Vuuren, John Frater
Published 2011-04-01Get full text
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Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection. by Emily Adland, Paolo Paioni, Christina Thobakgale, Leana Laker, Luisa Mori, Maximilian Muenchhoff, Anna Csala, Margaret Clapson, Jacquie Flynn, Vas Novelli, Jacob Hurst, Vanessa Naidoo, Roger Shapiro, Kuan-Hsiang Gary Huang, John Frater, Andrew Prendergast, Julia G Prado, Thumbi Ndung'u, Bruce D Walker, Mary Carrington, Pieter Jooste, Philip J R Goulder
Published 2015-06-01Get full text
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Dynamics of the blood plasma proteome during hyperacute HIV-1 infection by Jamirah Nazziwa, Eva Freyhult, Mun-Gwan Hong, Emil Johansson, Filip Årman, Jonathan Hare, Kamini Gounder, Melinda Rezeli, Tirthankar Mohanty, Sven Kjellström, Anatoli Kamali, Etienne Karita, William Kilembe, Matt A. Price, Pontiano Kaleebu, Susan Allen, Eric Hunter, Thumbi Ndung’u, Jill Gilmour, Sarah L. Rowland-Jones, Eduard Sanders, Amin S. Hassan, Joakim Esbjörnsson
Published 2024-12-01Get full text
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An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune contro... by Vinicius A Vieira, Emily Adland, David F G Malone, Maureen P Martin, Andreas Groll, M Azim Ansari, Maria C Garcia-Guerrero, Mari C Puertas, Maximilian Muenchhoff, Claudia Fortuny Guash, Christian Brander, Javier Martinez-Picado, Alasdair Bamford, Gareth Tudor-Williams, Thumbi Ndung'u, Bruce D Walker, Veron Ramsuran, John Frater, Pieter Jooste, Dimitra Peppa, Mary Carrington, Philip J R Goulder
Published 2021-11-01Get full text
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Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South... by Angelique Hölzemer, Christina F Thobakgale, Camilo A Jimenez Cruz, Wilfredo F Garcia-Beltran, Jonathan M Carlson, Nienke H van Teijlingen, Jaclyn K Mann, Manjeetha Jaggernath, Seung-gu Kang, Christian Körner, Amy W Chung, Jamie L Schafer, David T Evans, Galit Alter, Bruce D Walker, Philip J Goulder, Mary Carrington, Pia Hartmann, Thomas Pertel, Ruhong Zhou, Thumbi Ndung'u, Marcus Altfeld
Published 2015-11-01Get full text
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