Efficacy and pharmacodynamic effect of anti-CD73 and anti-PD-L1 monoclonal antibodies in combination with cytotoxic therapy: observations from mouse tumor models by Brajesh P. Kaistha, Gozde Kar, Andreas Dannhorn, Amanda Watkins, Grace Opoku-Ansah, Kristina Ilieva, Stefanie Mullins, Judith Anderton, Elena Galvani, Fabien Garcon, Jean-Martin Lapointe, Lee Brown, James Hair, Tim Slidel, Nadia Luheshi, Kelli Ryan, Elizabeth Hardaker, Simon Dovedi, Rakesh Kumar, Robert W. Wilkinson, Scott A. Hammond, Jim Eyles

Get full text

An affinity-modulated T cell engager targeting Claudin 18.2 shows potent anti-tumor activity with limited cytokine release by D Gareth Rees, Yun He, Scott A Hammond, Mark Cobbold, Nicolas Giraldo, Saso Cemerski, Marina Natoli, Yiping Rong, Jonathan Fitzgerald, Kathy Mulgrew, Simon J Dovedi, Miguel Gaspar, Christopher Lloyd, Jim Eyles, Laure Castan, Sharif Rahmy, Cathryn Kelton, Martin Korade, Oisin Huhn, Anna Sigurdardottir, Kathryn Ball, Laura Dallaway, Jonathan J Taylor, Phillip M Brailey, Aleksandra Toloczko, Maria A S Broggi, Andrew Kunihiro, Sudhanshu Abhishek

Get full text