Extracting the Epoch of Reionization Signal with 3D U-Net Neural Networks Using a Data-driven Systematic Effect Model by Li-Yang Gao, Léon V. E. Koopmans, Florent G. Mertens, Satyapan Munshi, Yichao Li, Stefanie A. Brackenhoff, Emilio Ceccotti, J. Kariuki Chege, Anshuman Acharya, Raghunath Ghara, Sambit K. Giri, Ilian T. Iliev, Garrelt Mellema, Xin Zhang

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