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Development of ketobenzothiazole-based peptidomimetic TMPRSS13 inhibitors with low nanomolar potency by Alexandre Joushomme, Antoine Désilets, William Champagne, Malihe Hassanzadeh, Gabriel Lemieux, Alice Gravel-Trudeau, Matthieu Lepage, Sabrina Lafrenière, Ulrike Froehlich, Karin List, Pierre-Luc Boudreault, Richard Leduc
Published 2025-12-01Get full text
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Structural basis of TMPRSS11D specificity and autocleavage activation by Bryan J. Fraser, Ryan P. Wilson, Sára Ferková, Olzhas Ilyassov, Jackie Lac, Aiping Dong, Yen-Yen Li, Alma Seitova, Yanjun Li, Zahra Hejazi, Tristan M. G. Kenney, Linda Z. Penn, Aled Edwards, Richard Leduc, Pierre-Luc Boudreault, Gregg B. Morin, François Bénard, Cheryl H. Arrowsmith
Published 2025-05-01Get full text
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A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants by Jimena Pérez-Vargas, Liam J. Worrall, Andrea D. Olmstead, Anh-Tien Ton, Jaeyong Lee, Ivan Villanueva, Connor A. H. Thompson, Svenja Dudek, Siobhan Ennis, Jason R. Smith, Tirosh Shapira, Joshua De Guzman, Shutong Gang, Fuqiang Ban, Marija Vuckovic, Michael Bielecki, Suzana Kovacic, Calem Kenward, Christopher Yee Hong, Danielle G. Gordon, Paul N. Levett, Mel Krajden, Richard Leduc, Pierre-Luc Boudreault, Masahiro Niikura, Mark Paetzel, Robert N. Young, Artem Cherkasov, Natalie C. J. Strynadka, François Jean
Published 2023-12-01Get full text
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