Adherence to Life’s Essential 8 enhances gut microbiota diversity and cognitive performance by Yannick N. Wadop, Jazmyn Muhammad, Rebecca Bernal, Claudia L. Satizabal, Claudia L. Satizabal, Claudia L. Satizabal, Claudia L. Satizabal, Alexa Beiser, Alexa Beiser, Alexa Beiser, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramnik Xavier, Ramnik Xavier, Ramnik Xavier, Tiffany Kautz, Tiffany Kautz, Sudha Seshadri, Sudha Seshadri, Sudha Seshadri, Sudha Seshadri, Jayandra Jung Himali, Jayandra Jung Himali, Jayandra Jung Himali, Jayandra Jung Himali, Jayandra Jung Himali, Jayandra Jung Himali, Bernard Fongang, Bernard Fongang, Bernard Fongang

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Biomarkers representing key aging-related biological pathways are associated with subclinical atherosclerosis and all-cause mortality: The Framingham Study. by Cecilia Castro-Diehl, Rachel Ehrbar, Vanesa Obas, Albin Oh, Ramachandran S Vasan, Vanessa Xanthakis

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Joint influences of obesity, diabetes, and hypertension on indices of ventricular remodeling: Findings from the community-based Framingham Heart Study. by Beatrice von Jeinsen, Ramachandran S Vasan, David D McManus, Gary F Mitchell, Susan Cheng, Vanessa Xanthakis

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Self-Reported Physical Activity and Relations to Growth and Neurotrophic Factors in Diabetes Mellitus: The Framingham Offspring Study by Nicole L. Spartano, Kendra L. Davis-Plourde, Jayandra J. Himali, Joanne M. Murabito, Ramachandran S. Vasan, Alexa S. Beiser, Sudha Seshadri

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Accelerometer‐determined physical activity and cognitive function in middle‐aged and older adults from two generations of the Framingham Heart Study by Nicole L. Spartano, Serkalem Demissie, Jayandra J. Himali, Kimberly A. Dukes, Joanne M. Murabito, Ramachandran S. Vasan, Alexa S. Beiser, Sudha Seshadri

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Association of Circulating Ceramides With Cardiac Structure and Function in the Community: The Framingham Heart Study by Chike C. Nwabuo, Meredith Duncan, Vanessa Xanthakis, Linda R. Peterson, Gary F. Mitchell, David McManus, Susan Cheng, Ramachandran S. Vasan

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Using family-based imputation in genome-wide association studies with large complex pedigrees: the Framingham Heart Study. by Ming-Huei Chen, Jie Huang, Wei-Min Chen, Martin G Larson, Caroline S Fox, Ramachandran S Vasan, Sudha Seshadri, Christopher J O'Donnell, Qiong Yang

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Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity by Oded Shaham, Ru Wei, Thomas J Wang, Catherine Ricciardi, Gregory D Lewis, Ramachandran S Vasan, Steven A Carr, Ravi Thadhani, Robert E Gerszten, Vamsi K Mootha

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Metabolomic Profiles of Body Mass Index in the Framingham Heart Study Reveal Distinct Cardiometabolic Phenotypes. by Jennifer E Ho, Martin G Larson, Anahita Ghorbani, Susan Cheng, Ming-Huei Chen, Michelle Keyes, Eugene P Rhee, Clary B Clish, Ramachandran S Vasan, Robert E Gerszten, Thomas J Wang

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Blood Pressure Responses During Exercise Were Associated With Average Home Blood Pressure and Home Blood Pressure Variability: The Electronic Framingham Heart Study by Xuzhi Wang, Yuankai Zhang, Chathurangi H. Pathiravasan, Nicole L. Spartano, Emelia J. Benjamin, David D. McManus, Gregory D. Lewis, Martin G. Larson, Ramachandran S. Vasan, Joanne M. Murabito, Chunyu Liu, Matthew Nayor

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Six Novel Loci Associated with Circulating VEGF Levels Identified by a Meta-analysis of Genome-Wide Association Studies. by Seung Hoan Choi, Daniela Ruggiero, Rossella Sorice, Ci Song, Teresa Nutile, Albert Vernon Smith, Maria Pina Concas, Michela Traglia, Caterina Barbieri, Ndeye Coumba Ndiaye, Maria G Stathopoulou, Vasiliki Lagou, Giovanni Battista Maestrale, Cinzia Sala, Stephanie Debette, Peter Kovacs, Lars Lind, John Lamont, Peter Fitzgerald, Anke Tönjes, Vilmundur Gudnason, Daniela Toniolo, Mario Pirastu, Celine Bellenguez, Ramachandran S Vasan, Erik Ingelsson, Anne-Louise Leutenegger, Andrew D Johnson, Anita L DeStefano, Sophie Visvikis-Siest, Sudha Seshadri, Marina Ciullo

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Identification of novel and rare variants associated with handgrip strength using whole genome sequence data from the NHLBI Trans-Omics in Precision Medicine (TOPMed) Program. by Chloé Sarnowski, Han Chen, Mary L Biggs, Sylvia Wassertheil-Smoller, Jan Bressler, Marguerite R Irvin, Kathleen A Ryan, David Karasik, Donna K Arnett, L Adrienne Cupples, David W Fardo, Stephanie M Gogarten, Benjamin D Heavner, Deepti Jain, Hyun Min Kang, Charles Kooperberg, Arch G Mainous, Braxton D Mitchell, Alanna C Morrison, Jeffrey R O'Connell, Bruce M Psaty, Kenneth Rice, Albert V Smith, Ramachandran S Vasan, B Gwen Windham, Douglas P Kiel, Joanne M Murabito, Kathryn L Lunetta, TOPMed Longevity and Healthy Aging Working Group, from the NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium

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Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. by Guangju Zhai, Alexander Teumer, Lisette Stolk, John R B Perry, Liesbeth Vandenput, Andrea D Coviello, Annemarie Koster, Jordana T Bell, Shalender Bhasin, Joel Eriksson, Anna Eriksson, Florian Ernst, Luigi Ferrucci, Timothy M Frayling, Daniel Glass, Elin Grundberg, Robin Haring, Asa K Hedman, Albert Hofman, Douglas P Kiel, Heyo K Kroemer, Yongmei Liu, Kathryn L Lunetta, Marcello Maggio, Mattias Lorentzon, Massimo Mangino, David Melzer, Iva Miljkovic, MuTHER Consortium, Alexandra Nica, Brenda W J H Penninx, Ramachandran S Vasan, Fernando Rivadeneira, Kerrin S Small, Nicole Soranzo, André G Uitterlinden, Henry Völzke, Scott G Wilson, Li Xi, Wei Vivian Zhuang, Tamara B Harris, Joanne M Murabito, Claes Ohlsson, Anna Murray, Frank H de Jong, Tim D Spector, Henri Wallaschofski

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Genetic determinants of serum testosterone concentrations in men. by Claes Ohlsson, Henri Wallaschofski, Kathryn L Lunetta, Lisette Stolk, John R B Perry, Annemarie Koster, Ann-Kristin Petersen, Joel Eriksson, Terho Lehtimäki, Ilpo T Huhtaniemi, Geoffrey L Hammond, Marcello Maggio, Andrea D Coviello, EMAS Study Group, Luigi Ferrucci, Margit Heier, Albert Hofman, Kate L Holliday, John-Olov Jansson, Mika Kähönen, David Karasik, Magnus K Karlsson, Douglas P Kiel, Yongmei Liu, Osten Ljunggren, Mattias Lorentzon, Leo-Pekka Lyytikäinen, Thomas Meitinger, Dan Mellström, David Melzer, Iva Miljkovic, Matthias Nauck, Maria Nilsson, Brenda Penninx, Stephen R Pye, Ramachandran S Vasan, Martin Reincke, Fernando Rivadeneira, Abdelouahid Tajar, Alexander Teumer, André G Uitterlinden, Jagadish Ulloor, Jorma Viikari, Uwe Völker, Henry Völzke, H Erich Wichmann, Tsung-Sheng Wu, Wei Vivian Zhuang, Elad Ziv, Frederick C W Wu, Olli Raitakari, Anna Eriksson, Martin Bidlingmaier, Tamara B Harris, Anna Murray, Frank H de Jong, Joanne M Murabito, Shalender Bhasin, Liesbeth Vandenput, Robin Haring

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Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium. by Joshua C Bis, Colleen Sitlani, Ryan Irvin, Christy L Avery, Albert Vernon Smith, Fangui Sun, Daniel S Evans, Solomon K Musani, Xiaohui Li, Stella Trompet, Bouwe P Krijthe, Tamara B Harris, P Miguel Quibrera, Jennifer A Brody, Serkalem Demissie, Barry R Davis, Kerri L Wiggins, Gregory J Tranah, Leslie A Lange, Nona Sotoodehnia, David J Stott, Oscar H Franco, Lenore J Launer, Til Stürmer, Kent D Taylor, L Adrienne Cupples, John H Eckfeldt, Nicholas L Smith, Yongmei Liu, James G Wilson, Susan R Heckbert, Brendan M Buckley, M Arfan Ikram, Eric Boerwinkle, Yii-Der Ida Chen, Anton J M de Craen, Andre G Uitterlinden, Jerome I Rotter, Ian Ford, Albert Hofman, Naveed Sattar, P Eline Slagboom, Rudi G J Westendorp, Vilmundur Gudnason, Ramachandran S Vasan, Thomas Lumley, Steven R Cummings, Herman A Taylor, Wendy Post, J Wouter Jukema, Bruno H Stricker, Eric A Whitsel, Bruce M Psaty, Donna Arnett

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Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure. by J Gustav Smith, Janine F Felix, Alanna C Morrison, Andreas Kalogeropoulos, Stella Trompet, Jemma B Wilk, Olof Gidlöf, Xinchen Wang, Michael Morley, Michael Mendelson, Roby Joehanes, Symen Ligthart, Xiaoyin Shan, Joshua C Bis, Ying A Wang, Marketa Sjögren, Julius Ngwa, Jeffrey Brandimarto, David J Stott, David Aguilar, Kenneth M Rice, Howard D Sesso, Serkalem Demissie, Brendan M Buckley, Kent D Taylor, Ian Ford, Chen Yao, Chunyu Liu, CHARGE-SCD consortium, EchoGen consortium, QT-IGC consortium, CHARGE-QRS consortium, Nona Sotoodehnia, Pim van der Harst, Bruno H Ch Stricker, Stephen B Kritchevsky, Yongmei Liu, J Michael Gaziano, Albert Hofman, Christine S Moravec, André G Uitterlinden, Manolis Kellis, Joyce B van Meurs, Kenneth B Margulies, Abbas Dehghan, Daniel Levy, Björn Olde, Bruce M Psaty, L Adrienne Cupples, J Wouter Jukema, Luc Djousse, Oscar H Franco, Eric Boerwinkle, Laurie A Boyer, Christopher Newton-Cheh, Javed Butler, Ramachandran S Vasan, Thomas P Cappola, Nicholas L Smith

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Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. by Guillaume Lettre, Cameron D Palmer, Taylor Young, Kenechi G Ejebe, Hooman Allayee, Emelia J Benjamin, Franklyn Bennett, Donald W Bowden, Aravinda Chakravarti, Al Dreisbach, Deborah N Farlow, Aaron R Folsom, Myriam Fornage, Terrence Forrester, Ervin Fox, Christopher A Haiman, Jaana Hartiala, Tamara B Harris, Stanley L Hazen, Susan R Heckbert, Brian E Henderson, Joel N Hirschhorn, Brendan J Keating, Stephen B Kritchevsky, Emma Larkin, Mingyao Li, Megan E Rudock, Colin A McKenzie, James B Meigs, Yang A Meng, Tom H Mosley, Anne B Newman, Christopher H Newton-Cheh, Dina N Paltoo, George J Papanicolaou, Nick Patterson, Wendy S Post, Bruce M Psaty, Atif N Qasim, Liming Qu, Daniel J Rader, Susan Redline, Muredach P Reilly, Alexander P Reiner, Stephen S Rich, Jerome I Rotter, Yongmei Liu, Peter Shrader, David S Siscovick, W H Wilson Tang, Herman A Taylor, Russell P Tracy, Ramachandran S Vasan, Kevin M Waters, Rainford Wilks, James G Wilson, Richard R Fabsitz, Stacey B Gabriel, Sekar Kathiresan, Eric Boerwinkle

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NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. by Nancy L Heard-Costa, M Carola Zillikens, Keri L Monda, Asa Johansson, Tamara B Harris, Mao Fu, Talin Haritunians, Mary F Feitosa, Thor Aspelund, Gudny Eiriksdottir, Melissa Garcia, Lenore J Launer, Albert V Smith, Braxton D Mitchell, Patrick F McArdle, Alan R Shuldiner, Suzette J Bielinski, Eric Boerwinkle, Fred Brancati, Ellen W Demerath, James S Pankow, Alice M Arnold, Yii-Der Ida Chen, Nicole L Glazer, Barbara McKnight, Bruce M Psaty, Jerome I Rotter, Najaf Amin, Harry Campbell, Ulf Gyllensten, Cristian Pattaro, Peter P Pramstaller, Igor Rudan, Maksim Struchalin, Veronique Vitart, Xiaoyi Gao, Aldi Kraja, Michael A Province, Qunyuan Zhang, Larry D Atwood, Josée Dupuis, Joel N Hirschhorn, Cashell E Jaquish, Christopher J O'Donnell, Ramachandran S Vasan, Charles C White, Yurii S Aulchenko, Karol Estrada, Albert Hofman, Fernando Rivadeneira, André G Uitterlinden, Jacqueline C M Witteman, Ben A Oostra, Robert C Kaplan, Vilmundur Gudnason, Jeffrey R O'Connell, Ingrid B Borecki, Cornelia M van Duijn, L Adrienne Cupples, Caroline S Fox, Kari E North

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Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk by Marios K. Georgakis, Rainer Malik, Omar El Bounkari, Natalie R. Hasbani, Jiang Li, Jennifer E. Huffman, Gabrielle Shakt, Reinier W. P. Tack, Tamara N. Kimball, Yaw Asare, Alanna C. Morrison, Noah L. Tsao, Renae Judy, Braxton D. Mitchell, Huichun Xu, May E. Montasser, Ron Do, Eimear E. Kenny, Ruth J. F. Loos, James G. Terry, John Jeffrey Carr, Joshua C. Bis, Bruce M. Psaty, W. T. Longstreth, Kendra A. Young, Sharon M. Lutz, Michael H. Cho, Jai Broome, Alyna T. Khan, Fei Fei Wang, Nancy Heard-Costa, Sudha Seshadri, Ramachandran S. Vasan, Nicholette D. Palmer, Barry I. Freedman, Donald W. Bowden, Lisa R. Yanek, Brian G. Kral, Lewis C. Becker, Patricia A. Peyser, Lawrence F. Bielak, Farah Ammous, April P. Carson, Michael E. Hall, Laura M. Raffield, Stephen S. Rich, Wendy S. Post, Russel P. Tracy, Kent D. Taylor, Xiuqing Guo, Michael C. Mahaney, Joanne E. Curran, John Blangero, Shoa L. Clarke, Jeffrey W. Haessler, Yao Hu, Themistocles L. Assimes, Charles Kooperberg, Jürgen Bernhagen, Christopher D. Anderson, Scott M. Damrauer, Ramin Zand, Jerome I. Rotter, Paul S. de Vries, Martin Dichgans

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Unveiling the Genetic Landscape of Coronary Artery Disease Through Common and Rare Structural Variants by Kruthika R. Iyer, Shoa L. Clarke, Rodrigo Guarischi‐Sousa, Ketrin Gjoni, Adam S. Heath, Erica P. Young, Nathan O. Stitziel, Cecelia Laurie, Jai G. Broome, Alyna T. Khan, Joshua P. Lewis, Huichun Xu, May E. Montasser, Kellan E. Ashley, Natalie R. Hasbani, Eric Boerwinkle, Alanna C. Morrison, Nathalie Chami, Ron Do, Ghislain Rocheleau, Donald M. Lloyd‐Jones, Rozenn N. Lemaitre, Joshua C. Bis, James S. Floyd, Gregory L. Kinney, Donald W. Bowden, Nicholette D. Palmer, Emelia J. Benjamin, Matthew Nayor, Lisa R. Yanek, Brian G. Kral, Lewis C. Becker, Sharon L. R. Kardia, Jennifer A. Smith, Lawrence F. Bielak, Arnita F. Norwood, Yuan‐I Min, April P. Carson, Wendy S. Post, Stephen S. Rich, David Herrington, Xiuqing Guo, Kent D. Taylor, JoAnn E. Manson, Nora Franceschini, Katherine S. Pollard, Braxton D. Mitchell, Ruth J. F. Loos, Myriam Fornage, Lifang Hou, Bruce M. Psaty, Kendra A. Young, Elizabeth A. Regan, Barry I. Freedman, Ramachandran S. Vasan, Daniel Levy, Rasika A. Mathias, Patricia A. Peyser, Laura M. Raffield, Charles Kooperberg, Alex P. Reiner, Jerome I. Rotter, Goo Jun, Paul S. de Vries, Themistocles L. Assimes

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