Research inefficiencies in external validation studies of the Framingham Wilson coronary heart disease risk rule: A systematic review. by Jong-Wook Ban, Lucy Abel, Richard Stevens, Rafael Perera

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Implementation framework for AI deployment at scale in healthcare systems by Hassan Sami Adnan, Amitis Shidani, Lei Clifton, Clare R. Bankhead, Rafael Perera-Salazar

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The diagnostic accuracy of a single CEA blood test in detecting colorectal cancer recurrence: Results from the FACS trial. by Bethany Shinkins, Brian D Nicholson, John Primrose, Rafael Perera, Timothy James, Sian Pugh, David Mant

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Investigating the association between recorded smoking cessation interventions and smoking cessation in people living with cardiovascular disease using UK general practice data by Angela Difeng Wu, Nicola Lindson, Rafael Perera, Min Gao, Paul Aveyard, Rachna Begh, Jamie Hartmann-Boyce

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Educational interventions delivered to prescribing advisers to influence primary care prescribing: a very low-cost pragmatic randomised trial using routine data from OpenPrescribin... by Helen J Curtis, Brian MacKenna, Bhavana Reddy, Alex J Walker, Sebastian Bacon, Rafael Perera, Ben Goldacre

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Are treatments more effective than placebos? A systematic review and meta-analysis. by Jeremy Howick, Claire Friedemann, Maria Tsakok, Robert Watson, Teresa Tsakok, Jennifer Thomas, Rafael Perera, Susannah Fleming, Carl Heneghan

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The evidence base for interventions delivered to children in primary care: an overview of cochrane systematic reviews. by Peter J Gill, Kay Yee Wang, David Mant, Lisa Hartling, Carl Heneghan, Rafael Perera, Terry Klassen, Anthony Harnden

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Pathways to Care for Critically Ill or Injured Children: A Cohort Study from First Presentation to Healthcare Services through to Admission to Intensive Care or Death. by Peter Hodkinson, Andrew Argent, Lee Wallis, Steve Reid, Rafael Perera, Sian Harrison, Matthew Thompson, Mike English, Ian Maconochie, Alison Ward

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CASNET2: evaluation of an electronic safety netting cancer toolkit for the primary care electronic health record: protocol for a pragmatic stepped-wedge RCT by Clare Bankhead, Rafael Perera, Simon de Lusignan, Ivelina Yonova, Susannah Fleming, Richard Hobbs, Brian D Nicholson, Yasemin Hirst, Afsana Bhuiya, Julian Sherlock

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Trends in kidney function testing in UK primary care since the introduction of the quality and outcomes framework: a retrospective cohort study using CPRD by Jason Oke, Rafael Perera, Christopher O’Callaghan, Jeffrey Aronson, Daniel Lasserson, Clare Taylor, Benjamin Feakins, Emily McFadden, Nathan Hill, Richard Stevens

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Clinical Prediction Models Incorporating Blood Test Trend for Cancer Detection: Systematic Review, Meta-Analysis, and Critical Appraisal by Pradeep S Virdee, Kiana K Collins, Claire Friedemann Smith, Xin Yang, Sufen Zhu, Nia Roberts, Jason L Oke, Clare Bankhead, Rafael Perera, FD Richard Hobbs, Brian D Nicholson

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Effects of antihypertensives, lipid-modifying drugs, glycaemic control drugs and sodium bicarbonate on the progression of stages 3 and 4 chronic kidney disease in adults: a systema... by Amitava Banerjee, Julie McLellan, Rafael Perera, Nia Roberts, Susannah Fleming, Kathryn S Taylor, Jan Y Verbakel, Clare R Bankhead, Daniel S Lasserson, Nicola Pidduck, Christopher A O'Callaghan, FD Richard Hobbs

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Pilot study to test the feasibility of a trial design and complex intervention on PRIoritising MUltimedication in Multimorbidity in general practices (PRIMUMpilot) by Rafael Perera, Marjan Van Den Akker, Ferdinand M Gerlach, Jose M Valderas, Martin Beyer, Christiane Muth, Lorenz Uhlmann, Corina Güthlin, Antje Erler, Sebastian Harder, Justine Rochon, Birgit Fullerton, André Knottnerus, Walter E Haefeli

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Predicting hospital admissions from individual patient data (IPD): an applied example to explore key elements driving external validity by Rafael Perera, Marjan Van Den Akker, Kym I E Snell, Joerg J Meerpohl, Ferdinand M Gerlach, Daniela Küllenberg de Gaudry, Ana Isabel González-González, Jeanet Blom, Christiane Muth, Walter Emil Haefeli, Karin M A Swart, Petra Elders, Henrik Rudolf, Ulrich Thiem, Andreas Daniel Meid, Truc Sophia Dinh, Donna Bosch-Lenders, Hans J Trampisch, Benno Flaig, Ghainsom Kom

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Study protocol: Comparison of different risk prediction modelling approaches for COVID-19 related death using the OpenSAFELY platform [version 2; peer review: 2 approved] by Richard Croker, Anna Schultze, Frank Hester, John Parry, Rafael Perera, Sam Harper, Rosalind M. Eggo, Liam Smeeth, Ewout Steyerberg, Caroline Minassian, Ruth Keogh, Karla Diaz-Ordaz, Stephen J.W. Evans, Elizabeth J. Williamson, Krishnan Bhaskaran, John Tazare, Helen I McDonald, Alex J. Walker, Sebastian Bacon, Laurie A. Tomlinson, Helen J. Curtis, Chris Bates, Caroline E. Morton, Harriet Forbes, Amir Mehrkar, Emily Nightingale, Brian D Nicholson, Richard Grieve, Dave Evans, Peter Inglesby, David Harrison, Ben Goldacre, David Leon, Jonathan Cockburn, Brian MacKenna, Rohini Mathur, Will J. Hulme, Nicholas G. Davies, Ian J. Douglas, Jessica Morley, Angel Wong, Christopher T. Rentsch

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