Philippe Froguel

Froguel in 2019 Philippe Froguel (born 14 April 1958) is a French physician and scientist who serves as chair in Genomic Medicine in the Department of Metabolism, Digestion and Reproduction at Imperial College London. His research has focused on the genetics of human diseases such as obesity and type 2 diabetes. This includes research identifying the genes glucokinase and HNF1 risk factors for type 2 diabetes. In 2007, he was elected to the Academy of Medical Sciences (UK). In 2017, he was elected corresponding member of the French Académie Nationale de Médecine, and he is also a member of the Mexican National Academy of Medicine (Academia Nacional de Medicina de México).

Froguel received his M.D. from Pierre and Marie Curie University and his Ph.D. from Paris Diderot University. Provided by Wikipedia
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  1. 1
    Role of the Unfolded Protein Response in β Cell Compensation and Failure during Diabetes

    Role of the Unfolded Protein Response in β Cell Compensation and Failure during Diabetes by Nabil Rabhi, Elisabet Salas, Philippe Froguel, Jean-Sébastien Annicotte

    Published 2014-01-01
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  2. 2
    Role of Ink4a/Arf Locus in Beta Cell Mass Expansion under Physiological and Pathological Conditions

    Role of Ink4a/Arf Locus in Beta Cell Mass Expansion under Physiological and Pathological Conditions by Elisabet Salas, Nabil Rabhi, Philippe Froguel, Jean-Sébastien Annicotte

    Published 2014-01-01
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  3. 3
    Identification of a variable number of tandem repeats polymorphism and characterization of LEF-1 response elements in the promoter of the IDO1 gene.

    Identification of a variable number of tandem repeats polymorphism and characterization of LEF-1 response elements in the promoter of the IDO1 gene. by Marion Soichot, Benjamin Hennart, Alaa Al Saabi, Audrey Leloire, Philippe Froguel, Claire Levy-Marchal, Odile Poulain-Godefroy, Delphine Allorge

    Published 2011-01-01
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  4. 4
    Meal frequencies modify the effect of common genetic variants on body mass index in adolescents of the northern Finland birth cohort 1986.

    Meal frequencies modify the effect of common genetic variants on body mass index in adolescents of the northern Finland birth cohort 1986. by Anne Jääskeläinen, Ursula Schwab, Marjukka Kolehmainen, Marika Kaakinen, Markku J Savolainen, Philippe Froguel, Stéphane Cauchi, Marjo-Riitta Järvelin, Jaana Laitinen

    Published 2013-01-01
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  5. 5
    Small deletion variants have stable breakpoints commonly associated with alu elements.

    Small deletion variants have stable breakpoints commonly associated with alu elements. by Adam J de Smith, Robin G Walters, Lachlan J M Coin, Israel Steinfeld, Zohar Yakhini, Rob Sladek, Philippe Froguel, Alexandra I F Blakemore

    Published 2008-08-01
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  6. 6
    Integration of clinical data with a genome‐scale metabolic model of the human adipocyte

    Integration of clinical data with a genome‐scale metabolic model of the human adipocyte by Adil Mardinoglu, Rasmus Agren, Caroline Kampf, Anna Asplund, Intawat Nookaew, Peter Jacobson, Andrew J Walley, Philippe Froguel, Lena M Carlsson, Mathias Uhlen, Jens Nielsen

    Published 2013-03-01
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  7. 7
    What Is the Best NGS Enrichment Method for the Molecular Diagnosis of Monogenic Diabetes and Obesity?

    What Is the Best NGS Enrichment Method for the Molecular Diagnosis of Monogenic Diabetes and Obesity? by Julien Philippe, Mehdi Derhourhi, Emmanuelle Durand, Emmanuel Vaillant, Aurélie Dechaume, Iandry Rabearivelo, Véronique Dhennin, Martine Vaxillaire, Franck De Graeve, Olivier Sand, Philippe Froguel, Amélie Bonnefond

    Published 2015-01-01
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  8. 8
    Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice.

    Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice. by Kassem Makki, Solenne Taront, Olivier Molendi-Coste, Emmanuel Bouchaert, Bernadette Neve, Elodie Eury, Stéphane Lobbens, Myriam Labalette, Hélène Duez, Bart Staels, David Dombrowicz, Philippe Froguel, Isabelle Wolowczuk

    Published 2014-01-01
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  9. 9
    GAD2 on chromosome 10p12 is a candidate gene for human obesity.

    GAD2 on chromosome 10p12 is a candidate gene for human obesity. by Philippe Boutin, Christian Dina, Francis Vasseur, Séverine Dubois, Laetitia Corset, Karin Séron, Lynn Bekris, Janice Cabellon, Bernadette Neve, Valérie Vasseur-Delannoy, Mohamed Chikri, M Aline Charles, Karine Clement, Ake Lernmark, Philippe Froguel

    Published 2003-12-01
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  10. 10
    Glucose-dependent regulation of NR2F2 promoter and influence of SNP-rs3743462 on whole body insulin sensitivity.

    Glucose-dependent regulation of NR2F2 promoter and influence of SNP-rs3743462 on whole body insulin sensitivity. by Marie Boutant, Oscar Henrique Pereira Ramos, Cécile Lecoeur, Emmanuel Vaillant, Julien Philippe, Pili Zhang, Anaïs Perilhou, Beatriz Valcarcel, Sylvain Sebert, Mario-Ritta Jarvelin, Beverley Balkau, Donald Scott, Philippe Froguel, Martine Vaxillaire, Mireille Vasseur-Cognet

    Published 2012-01-01
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  11. 11
    Molecular diagnosis of neonatal diabetes mellitus using next-generation sequencing of the whole exome.

    Molecular diagnosis of neonatal diabetes mellitus using next-generation sequencing of the whole exome. by Amélie Bonnefond, Emmanuelle Durand, Olivier Sand, Franck De Graeve, Sophie Gallina, Kanetee Busiah, Stéphane Lobbens, Albane Simon, Christine Bellanné-Chantelot, Louis Létourneau, Raphael Scharfmann, Jérôme Delplanque, Robert Sladek, Michel Polak, Martine Vaxillaire, Philippe Froguel

    Published 2010-10-01
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  12. 12
    Estimation of newborn risk for child or adolescent obesity: lessons from longitudinal birth cohorts.

    Estimation of newborn risk for child or adolescent obesity: lessons from longitudinal birth cohorts. by Anita Morandi, David Meyre, Stéphane Lobbens, Ken Kleinman, Marika Kaakinen, Sheryl L Rifas-Shiman, Vincent Vatin, Stefan Gaget, Anneli Pouta, Anna-Liisa Hartikainen, Jaana Laitinen, Aimo Ruokonen, Shikta Das, Anokhi Ali Khan, Paul Elliott, Claudio Maffeis, Matthew W Gillman, Marjo-Riitta Järvelin, Philippe Froguel

    Published 2012-01-01
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  13. 13
    What is the contribution of two genetic variants regulating VEGF levels to type 2 diabetes risk and to microvascular complications?

    What is the contribution of two genetic variants regulating VEGF levels to type 2 diabetes risk and to microvascular complications? by Amélie Bonnefond, Pierre-Jean Saulnier, Maria G Stathopoulou, Niels Grarup, Ndeye Coumba Ndiaye, Ronan Roussel, Mohsen Azimi Nezhad, Aurélie Dechaume, Olivier Lantieri, Serge Hercberg, Torsten Lauritzen, Beverley Balkau, Julia S El-Sayed Moustafa, Torben Hansen, Oluf Pedersen, Philippe Froguel, Guillaume Charpentier, Michel Marre, Samy Hadjadj, Sophie Visvikis-Siest

    Published 2013-01-01
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  14. 14
    A framework for conducting GWAS using repeated measures data with an application to childhood BMI

    A framework for conducting GWAS using repeated measures data with an application to childhood BMI by Kimberley Burrows, Anni Heiskala, Jonathan P. Bradfield, Zhanna Balkhiyarova, Lijiao Ning, Mathilde Boissel, Yee-Ming Chan, Philippe Froguel, Amelie Bonnefond, Hakon Hakonarson, Alexessander Couto Alves, Deborah A. Lawlor, Marika Kaakinen, Marjo-Riitta Järvelin, Struan F. A. Grant, Kate Tilling, Inga Prokopenko, Sylvain Sebert, Mickaël Canouil, Nicole M. Warrington

    Published 2024-11-01
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  15. 15
    Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.

    Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value. by Stéphane Cauchi, David Meyre, Emmanuelle Durand, Christine Proença, Michel Marre, Samy Hadjadj, Hélène Choquet, Franck De Graeve, Stefan Gaget, Frederic Allegaert, Jérôme Delplanque, Marshall Alan Permutt, Jon Wasson, Ilana Blech, Guillaume Charpentier, Beverley Balkau, Anne-Claire Vergnaud, Sébastien Czernichow, Wolfgang Patsch, Mohamed Chikri, Benjamin Glaser, Robert Sladek, Philippe Froguel

    Published 2008-05-01
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  16. 16
    GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm.

    GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm. by Leonardo Bottolo, Marc Chadeau-Hyam, David I Hastie, Tanja Zeller, Benoit Liquet, Paul Newcombe, Loic Yengo, Philipp S Wild, Arne Schillert, Andreas Ziegler, Sune F Nielsen, Adam S Butterworth, Weang Kee Ho, Raphaële Castagné, Thomas Munzel, David Tregouet, Mario Falchi, François Cambien, Børge G Nordestgaard, Fredéric Fumeron, Anne Tybjærg-Hansen, Philippe Froguel, John Danesh, Enrico Petretto, Stefan Blankenberg, Laurence Tiret, Sylvia Richardson

    Published 2013-01-01
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  17. 17
    A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels.

    A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels. by Philippe Froguel, Ndeye Coumba Ndiaye, Amélie Bonnefond, Nabila Bouatia-Naji, Aurélie Dechaume, Gérard Siest, Bernard Herbeth, Mario Falchi, Leonardo Bottolo, Rosa-Maria Guéant-Rodriguez, Cécile Lecoeur, Michel R Langlois, Yann Labrune, Aimo Ruokonen, Said El Shamieh, Maria G Stathopoulou, Anita Morandi, Claudio Maffeis, David Meyre, Joris R Delanghe, Peter Jacobson, Lars Sjöström, Lena M S Carlsson, Andrew Walley, Paul Elliott, Marjo-Riita Jarvelin, George V Dedoussis, Sophie Visvikis-Siest

    Published 2012-01-01
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  18. 18
    Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?

    Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore? by Rajkumar Dorajoo, Ruoying Li, Mohammad Kamran Ikram, Jianjun Liu, Philippe Froguel, Jeannette Lee, Xueling Sim, Rick Twee-Hee Ong, Wan Ting Tay, Chen Peng, Terri L Young, Alexandra I F Blakemore, Ching Yu Cheng, Tin Aung, Paul Mitchell, Jie Jin Wang, Caroline C Klaver, Eric Boerwinkle, Ronald Klein, David S Siscovick, Richard A Jensen, Vilmundur Gudnason, Albert Vernon Smith, Yik Ying Teo, Tien Yin Wong, E-Shyong Tai, Chew-Kiat Heng, Yechiel Friedlander

    Published 2013-01-01
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  19. 19
    Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity.

    Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity. by Robin G Walters, Lachlan J M Coin, Aimo Ruokonen, Adam J de Smith, Julia S El-Sayed Moustafa, Sebastien Jacquemont, Paul Elliott, Tõnu Esko, Anna-Liisa Hartikainen, Jaana Laitinen, Katrin Männik, Danielle Martinet, David Meyre, Matthias Nauck, Claudia Schurmann, Rob Sladek, Gudmar Thorleifsson, Unnur Thorsteinsdóttir, Armand Valsesia, Gerard Waeber, Flore Zufferey, Beverley Balkau, François Pattou, Andres Metspalu, Henry Völzke, Peter Vollenweider, Kári Stefansson, Marjo-Riitta Järvelin, Jacques S Beckmann, Philippe Froguel, Alexandra I F Blakemore

    Published 2013-01-01
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  20. 20
    Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups.

    Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. by André Scherag, Christian Dina, Anke Hinney, Vincent Vatin, Susann Scherag, Carla I G Vogel, Timo D Müller, Harald Grallert, H-Erich Wichmann, Beverley Balkau, Barbara Heude, Marjo-Riitta Jarvelin, Anna-Liisa Hartikainen, Claire Levy-Marchal, Jacques Weill, Jérôme Delplanque, Antje Körner, Wieland Kiess, Peter Kovacs, Nigel W Rayner, Inga Prokopenko, Mark I McCarthy, Helmut Schäfer, Ivonne Jarick, Heiner Boeing, Eva Fisher, Thomas Reinehr, Joachim Heinrich, Peter Rzehak, Dietrich Berdel, Michael Borte, Heike Biebermann, Heiko Krude, Dieter Rosskopf, Christian Rimmbach, Winfried Rief, Tobias Fromme, Martin Klingenspor, Annette Schürmann, Nadja Schulz, Markus M Nöthen, Thomas W Mühleisen, Raimund Erbel, Karl-Heinz Jöckel, Susanne Moebus, Tanja Boes, Thomas Illig, Philippe Froguel, Johannes Hebebrand, David Meyre

    Published 2010-04-01
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