The temporal onset of associations of cortical proteins with cognitive resilience vary during late life by Andrea R. Zammit, Tianhao Wang, Lei Yu, Shahram Oveisgharan, Vladislav A. Petyuk, Philip L. De Jager, Julie A. Schneider, David A. Bennett, Aron S. Buchman

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Defining the role of the MHC in autoimmunity: a review and pooled analysis. by Michelle M A Fernando, Christine R Stevens, Emily C Walsh, Philip L De Jager, Philippe Goyette, Robert M Plenge, Timothy J Vyse, John D Rioux

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Proteome-wide association studies using summary pQTL data of brain, CSF, and plasma identify 30 risk genes of Alzheimer’s disease dementia by Tingyang Hu, Qiang Liu, Qile Dai, Aron S. Buchman, David A. Bennett, Shinya Tasaki, Yanling Wang, Nicholas T. Seyfried, Philip L. De Jager, Michael P. Epstein, Jingjing Yang

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Genotyping TOMM40′523 poly-T polymorphisms using whole-genome sequencing by Ricardo A. Vialle, Lei Yu, Yan Li, Roberto T. Raittz, Jose M. Farfel, Philip L. De Jager, Julie A. Schneider, Lisa L. Barnes, Shinya Tasaki, David A. Bennett

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24-hour rhythms of DNA methylation and their relation with rhythms of RNA expression in the human dorsolateral prefrontal cortex. by Andrew S P Lim, Gyan P Srivastava, Lei Yu, Lori B Chibnik, Jishu Xu, Aron S Buchman, Julie A Schneider, Amanda J Myers, David A Bennett, Philip L De Jager

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A Transcriptomic Signature of Depressive Symptoms in Late Life by Stuart Matan-Lithwick, Melissa C. Misztal, Mu Yang, Thomas DeLong, Shreejoy Tripathy, Jeffrey T. Dunn, David A. Bennett, Philip L. De Jager, Yanling Wang, Daniel W. Fisher, Hongxin Dong, Daniel Felsky

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Contributions of major tau kinase activation and phospho-tau accumulation to cortical and hippocampal tangle formation and cognition in older adults by Elena Hernández-Hernández, Vladislav A. Petyuk, Júlia Valor-Blanquer, Fernando Yáñez-Gómez, Alasdair M. Barr, Philip L. De Jager, Er-Yun Chen, Sue E. Leurgans, Julie A. Schneider, David A. Bennett, William G. Honer, M. Julia García-Fuster, Alfredo Ramos-Miguel

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Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data. by Charles C White, Hyun-Sik Yang, Lei Yu, Lori B Chibnik, Robert J Dawe, Jingyun Yang, Hans-Ulrich Klein, Daniel Felsky, Alfredo Ramos-Miguel, Konstantinos Arfanakis, William G Honer, Reisa A Sperling, Julie A Schneider, David A Bennett, Philip L De Jager

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Structural variants linked to Alzheimer’s disease and other common age-related clinical and neuropathologic traits by Ricardo A. Vialle, Katia de Paiva Lopes, Yan Li, Bernard Ng, Julie A. Schneider, Aron S. Buchman, Yanling Wang, Jose M. Farfel, Lisa L. Barnes, Aliza P. Wingo, Thomas S. Wingo, Nicholas T. Seyfried, Philip L. De Jager, Chris Gaiteri, Shinya Tasaki, David A. Bennett

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Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery. by Amanda A Fox, Mias Pretorius, Kuang-Yu Liu, Charles D Collard, Tjorvi E Perry, Stanton K Shernan, Philip L De Jager, David A Hafler, Daniel S Herman, Steven R DePalma, Dan M Roden, Jochen D Muehlschlegel, Brian S Donahue, Dawood Darbar, J G Seidman, Simon C Body, Christine E Seidman

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Ancestral risk modification for multiple sclerosis susceptibility detected across the Major Histocompatibility Complex in a multi-ethnic population. by Ashley H Beecham, Lilyana Amezcua, Angel Chinea, Clara P Manrique, Lissette Gomez, Andrea Martinez, Gary W Beecham, Nikolaos A Patsopoulos, Tanuja Chitnis, Howard L Weiner, Philip L De Jager, Esteban G Burchard, Brett T Lund, Kathryn C Fitzgerald, Peter A Calabresi, Silvia R Delgado, Jorge R Oksenberg, Jacob L McCauley

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IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. by Lisa M Maier, Christopher E Lowe, Jason Cooper, Kate Downes, David E Anderson, Christopher Severson, Pamela M Clark, Brian Healy, Neil Walker, Cristin Aubin, Jorge R Oksenberg, Stephen L Hauser, Alistair Compston, Stephen Sawcer, International Multiple Sclerosis Genetics Consortium, Philip L De Jager, Linda S Wicker, John A Todd, David A Hafler

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Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. by Nikolaos A Patsopoulos, Lisa F Barcellos, Rogier Q Hintzen, Catherine Schaefer, Cornelia M van Duijn, Janelle A Noble, Towfique Raj, IMSGC, ANZgene, Pierre-Antoine Gourraud, Barbara E Stranger, Jorge Oksenberg, Tomas Olsson, Bruce V Taylor, Stephen Sawcer, David A Hafler, Mary Carrington, Philip L De Jager, Paul I W de Bakker

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Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease by Matthias Arnold, Mustafa Buyukozkan, P. Murali Doraiswamy, Kwangsik Nho, Tong Wu, Vilmundur Gudnason, Lenore J. Launer, Rui Wang-Sattler, Jerzy Adamski, The Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Metabolomics Consortium, Philip L. De Jager, Nilüfer Ertekin-Taner, David A. Bennett, Andrew J. Saykin, Annette Peters, Karsten Suhre, Rima Kaddurah-Daouk, Gabi Kastenmüller, Jan Krumsiek

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Pervasive sharing of genetic effects in autoimmune disease. by Chris Cotsapas, Benjamin F Voight, Elizabeth Rossin, Kasper Lage, Benjamin M Neale, Chris Wallace, Gonçalo R Abecasis, Jeffrey C Barrett, Timothy Behrens, Judy Cho, Philip L De Jager, James T Elder, Robert R Graham, Peter Gregersen, Lars Klareskog, Katherine A Siminovitch, David A van Heel, Cisca Wijmenga, Jane Worthington, John A Todd, David A Hafler, Stephen S Rich, Mark J Daly, FOCiS Network of Consortia

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Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway. by Gang Li, Dorothée Diogo, Di Wu, Jim Spoonamore, Vlado Dancik, Lude Franke, Fina Kurreeman, Elizabeth J Rossin, Grant Duclos, Cathy Hartland, Xuezhong Zhou, Kejie Li, Jun Liu, Philip L De Jager, Katherine A Siminovitch, Alexandra Zhernakova, Soumya Raychaudhuri, John Bowes, Steve Eyre, Leonid Padyukov, Peter K Gregersen, Jane Worthington, Rheumatoid Arthritis Consortium International (RACI), Namrata Gupta, Paul A Clemons, Eli Stahl, Nicola Tolliday, Robert M Plenge

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Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome. by Denis A Baird, Jimmy Z Liu, Jimmy Z Liu, Jie Zheng, Solveig K Sieberts, Thanneer Perumal, Benjamin Elsworth, Tom G Richardson, Chia-Yen Chen, Minerva M Carrasquillo, Mariet Allen, Joseph S Reddy, Philip L De Jager, Nilufer Ertekin-Taner, Lara M Mangravite, Ben Logsdon, Karol Estrada, Philip C Haycock, Gibran Hemani, Heiko Runz, George Davey Smith, Tom R Gaunt, AMP-AD eQTL working group

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Integration of sequence data from a Consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene. by Yukinori Okada, Dorothee Diogo, Jeffrey D Greenberg, Faten Mouassess, Walid A L Achkar, Robert S Fulton, Joshua C Denny, Namrata Gupta, Daniel Mirel, Stacy Gabriel, Gang Li, Joel M Kremer, Dimitrios A Pappas, Robert J Carroll, Anne E Eyler, Gosia Trynka, Eli A Stahl, Jing Cui, Richa Saxena, Marieke J H Coenen, Henk-Jan Guchelaar, Tom W J Huizinga, Philippe Dieudé, Xavier Mariette, Anne Barton, Helena Canhão, João E Fonseca, Niek de Vries, Paul P Tak, Larry W Moreland, S Louis Bridges, Corinne Miceli-Richard, Hyon K Choi, Yoichiro Kamatani, Pilar Galan, Mark Lathrop, Towfique Raj, Philip L De Jager, Soumya Raychaudhuri, Jane Worthington, Leonid Padyukov, Lars Klareskog, Katherine A Siminovitch, Peter K Gregersen, Elaine R Mardis, Thurayya Arayssi, Layla A Kazkaz, Robert M Plenge

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Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis. by Jing Cui, Eli A Stahl, Saedis Saevarsdottir, Corinne Miceli, Dorothee Diogo, Gosia Trynka, Towfique Raj, Maša Umiċeviċ Mirkov, Helena Canhao, Helena Canhao, Katsunori Ikari, Chikashi Terao, Yukinori Okada, Sara Wedrén, Johan Askling, Hisashi Yamanaka, Shigeki Momohara, Atsuo Taniguchi, Koichiro Ohmura, Fumihiko Matsuda, Tsuneyo Mimori, Namrata Gupta, Manik Kuchroo, Ann W Morgan, John D Isaacs, Anthony G Wilson, Kimme L Hyrich, Marieke Herenius, Marieke E Doorenspleet, Paul-Peter Tak, J Bart A Crusius, Irene E van der Horst-Bruinsma, Gert Jan Wolbink, Piet L C M van Riel, Mart van de Laar, Henk-Jan Guchelaar, Nancy A Shadick, Cornelia F Allaart, Tom W J Huizinga, Rene E M Toes, Robert P Kimberly, S Louis Bridges, Lindsey A Criswell, Larry W Moreland, João Eurico Fonseca, Niek de Vries, Barbara E Stranger, Philip L De Jager, Soumya Raychaudhuri, Michael E Weinblatt, Peter K Gregersen, Xavier Mariette, Anne Barton, Leonid Padyukov, Marieke J H Coenen, Elizabeth W Karlson, Robert M Plenge

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Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer’s dis... by Farid Rajabli, Penelope Benchek, Giuseppe Tosto, Nicholas Kushch, Jin Sha, Katrina Bazemore, Congcong Zhu, Wan-Ping Lee, Jacob Haut, Kara L. Hamilton-Nelson, Nicholas R. Wheeler, Yi Zhao, John J. Farrell, Michelle A. Grunin, Yuk Yee Leung, Pavel P. Kuksa, Donghe Li, Eder Lucio da Fonseca, Jesse B. Mez, Ellen L. Palmer, Jagan Pillai, Richard M. Sherva, Yeunjoo E. Song, Xiaoling Zhang, Takeshi Ikeuchi, Taha Iqbal, Omkar Pathak, Otto Valladares, Dolly Reyes-Dumeyer, Amanda B. Kuzma, Erin Abner, Larry D. Adams, Perrie M. Adams, Alyssa Aguirre, Marilyn S. Albert, Roger L. Albin, Mariet Allen, Lisa Alvarez, Liana G. Apostolova, Steven E. Arnold, Sanjay Asthana, Craig S. Atwood, Sanford Auerbach, Gayle Ayres, Clinton T. Baldwin, Robert C. Barber, Lisa L. Barnes, Sandra Barral, Thomas G. Beach, James T. Becker, Gary W. Beecham, Duane Beekly, Bruno A. Benitez, David Bennett, John Bertelson, Thomas D. Bird, Deborah Blacker, Bradley F. Boeve, James D. Bowen, Adam Boxer, James Brewer, James R. Burke, Jeffrey M. Burns, Joseph D. Buxbaum, Nigel J. Cairns, Laura B. Cantwell, Chuanhai Cao, Christopher S. Carlson, Cynthia M. Carlsson, Regina M. Carney, Minerva M. Carrasquillo, Scott Chasse, Marie-Francoise Chesselet, Nathaniel A. Chin, Helena C. Chui, Jaeyoon Chung, Suzanne Craft, Paul K. Crane, David H. Cribbs, Elizabeth A. Crocco, Carlos Cruchaga, Michael L. Cuccaro, Munro Cullum, Eveleen Darby, Barbara Davis, Philip L. De Jager, Charles DeCarli, John DeToledo, Malcolm Dick, Dennis W. Dickson, Beth A. Dombroski, Rachelle S. Doody, Ranjan Duara, NIlüfer Ertekin-Taner, Denis A. Evans, Kelley M. Faber, Thomas J. Fairchild, Kenneth B. Fallon, David W. Fardo, Martin R. Farlow, Victoria Fernandez-Hernandez, Steven Ferris, Robert P. Friedland, Tatiana M. Foroud, Matthew P. Frosch, Brian Fulton-Howard, Douglas R. Galasko, Adriana Gamboa, Marla Gearing, Daniel H. Geschwind, Bernardino Ghetti, John R. Gilbert, Rodney C.P. Go, Alison M. Goate, Thomas J. Grabowski, Neill R. Graff-Radford, Robert C. Green, John H. Growdon, Hakon Hakonarson, James Hall, Ronald L. Hamilton, Oscar Harari, John Hardy, Lindy E. Harrell, Elizabeth Head, Victor W. Henderson, Michelle Hernandez, Timothy Hohman, Lawrence S. Honig, Ryan M. Huebinger, Matthew J. Huentelman, Christine M. Hulette, Bradley T. Hyman, Linda S. Hynan, Laura Ibanez, Gail P. Jarvik, Suman Jayadev, Lee-Way Jin, Kim Johnson, Leigh Johnson, M. Ilyas Kamboh, Anna M. Karydas, Mindy J. Katz, John S. Kauwe, Jeffrey A. Kaye, C. Dirk Keene, Aisha Khaleeq, Masataka Kikuchi, Ronald Kim, Janice Knebl, Neil W. Kowall, Joel H. Kramer, Walter A. Kukull, Frank M. LaFerla, James J. Lah, Eric B. Larson, Alan Lerner, James B. Leverenz, Allan I. Levey, Andrew P. Lieberman, Richard B. Lipton, Mark Logue, Oscar L. Lopez, Kathryn L. Lunetta, Constantine G. Lyketsos, Douglas Mains, Flanagan E. Margaret, Daniel C. Marson, Eden RR. Martin, Frank Martiniuk, Deborah C. Mash, Eliezer Masliah, Paul Massman, Arjun Masurkar, Wayne C. McCormick, Susan M. McCurry, Andrew N. McDavid, Stefan McDonough, Ann C. McKee, Marsel Mesulam, Bruce L. Miller, Carol A. Miller, Joshua W. Miller, Thomas J. Montine, Edwin S. Monuki, John C. Morris, Shubhabrata Mukherjee, Amanda J. Myers, Trung Nguyen, Thomas Obisesan, Sid O’Bryant, John M. Olichney, Marcia Ory, Raymond Palmer, Joseph E. Parisi, Henry L. Paulson, Valory Pavlik, David Paydarfar, Victoria Perez, Elaine Peskind, Ronald C. Petersen, Helen Petrovitch, Aimee Pierce, Marsha Polk, Wayne W. Poon, Huntington Potter, Liming Qu, Mary Quiceno, Joseph F. Quinn, Ashok Raj, Murray Raskind, Eric M. Reiman, Barry Reisberg, Joan S. Reisch, John M. Ringman, Erik D. Roberson, Monica Rodriguear, Ekaterina Rogaeva, Howard J. Rosen, Roger N. Rosenberg, Donald R. Royall, Marwan Sabbagh, A. Dessa Sadovnick, Mark A. Sager, Mary Sano, Andrew J. Saykin, Julie A. Schneider, Lon S. Schneider, William W. Seeley, Susan H. Slifer, Scott Small, Amanda G. Smith, Janet P. Smith, Joshua A. Sonnen, Salvatore Spina, Peter St George-Hyslop, Takiyah D. Starks, Robert A. Stern, Alan B. Stevens, Stephen M. Strittmatter, David Sultzer, Russell H. Swerdlow, Rudolph E. Tanzi, Jeffrey L. Tilson, John Q. Trojanowski, Juan C. Troncoso, Magda Tsolaki, Debby W. Tsuang, Vivianna M. Van Deerlin, Linda J. van Eldik, Jeffery M. Vance, Badri N. Vardarajan, Robert Vassar, Harry V. Vinters, Jean-Paul Vonsattel, Sandra Weintraub, Kathleen A. Welsh-Bohmer, Patrice L. Whitehead, Ellen M. Wijsman, Kirk C. Wilhelmsen, Benjamin Williams, Jennifer Williamson, Henrik Wilms, Thomas S. Wingo, Thomas Wisniewski, Randall L. Woltjer, Martin Woon, Clinton B. Wright, Chuang-Kuo Wu, Steven G. Younkin, Chang-En Yu, Lei Yu, Xiongwei Zhu, Brian W. Kunkle, William S. Bush, Akinori Miyashita, Goldie S. Byrd, Li-San Wang, Lindsay A. Farrer, Jonathan L. Haines, Richard Mayeux, Margaret A. Pericak-Vance, Gerard D. Schellenberg, Gyungah R. Jun, Christiane Reitz, Adam C. Naj, on behalf of Alzheimer’s Disease Genetics Consortium (ADGC)

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