The economic burden of antibiotic resistance: A systematic review and meta-analysis. by Ak Narayan Poudel, Shihua Zhu, Nicola Cooper, Paul Little, Carolyn Tarrant, Matthew Hickman, Guiqing Yao

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Currently prescribed drugs in the UK that could upregulate or downregulate ACE2 in COVID-19 disease: a systematic review by Paul Little, Simon J Griffin, Hajira Dambha-Miller, Nazrul Islam, Ali Albasri, Christopher R Wilcox, Sam Hodgson, Shareen Khan

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A qualitative process evaluation of a nasal spray intervention to prevent respiratory tract infections. by Amelia Dennis, Judith Joseph, Kate Greenwell, Sascha Miller, Jane Vennik, Laura Dennison, Sian Holt, Katherine Bradbury, Adam W A Geraghty, Paul Little, Lucy Yardley

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Continued high rates of antibiotic prescribing to adults with respiratory tract infection: survey of 568 UK general practices by Paul Little, Lucy Yardley, Martin C Gulliford, Judith Charlton, Lisa McDermott, Michael V Moore, Mark Ashworth, Tjeerd van Staa, Alex Dregan, Gerard McCann

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Prognostic factors and prediction models for hospitalisation and all-cause mortality in adults presenting to primary care with a lower respiratory tract infection: a systematic rev... by Paul Little, Frans H Rutten, Geert-Jan Geersing, Maarten van Smeden, Roderick P Venekamp, Tamara N Platteel, Merijn H Rijk, Teun M C van den Berg

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A complex intervention to reduce antibiotic prescribing in rural China: a cluster randomised controlled trialResearch in context by Xingrong Shen, Beth Stuart, Enci Cui, Rong Liu, Tingting Zhang, Jing Chai, Wenjuan Cong, Xiaowen Hu, Isabel Oliver, Guiqing Yao, Paul Little, Helen Lambert, Lucy Yardley, Christie Cabral, Debin Wang

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Probability of sepsis after infection consultations in primary care in the United Kingdom in 2002-2017: Population-based cohort study and decision analytic model. by Martin C Gulliford, Judith Charlton, Joanne R Winter, Xiaohui Sun, Emma Rezel-Potts, Catey Bunce, Robin Fox, Paul Little, Alastair D Hay, Michael V Moore, Mark Ashworth, SafeAB Study Group

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Feasibility trial of a new digital training package to enhance primary care practitioners' communication of clinical empathy and realistic optimism. by Felicity Bishop, Jeremy Howick, Jane Vennik, Jennifer Bostock, Paul Little, Christian Mallen, Leanne Morrison, Mary Steele, Beth Stuart, Stephanie Hughes, Kirsten Smith, Mohana Ratnapalan, Emily Lyness, Hajira Dambha-Miller, Riya Tiwari, Clare Lockyer-Stevens, Hazel Everitt

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Supporting self-management of low back pain with an internet intervention in primary care: a protocol for a randomised controlled trial of clinical and cost-effectiveness (SupportB... by Beth Stuart, Paul Little, Lucy Yardley, Stephanie Hughes, Adam W A Geraghty, Elaine Hay, Gemma Mansell, Nadine E Foster, Jonathan Hill, Gareth Griffiths, Frances Webley, Lorraine Durcan, Alannah Morgan, Sarah Bathers, Stephanie Butler-Walley, Simon Wathall, Linda Leigh

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Cost-effectiveness of Spironolactone for Adult Female Acne (SAFA): economic evaluation alongside a randomised controlled trial by Ingrid Muller, Miriam Santer, Beth Stuart, Paul Little, Matthew J Ridd, Karen Thomas, Nick Francis, Kim S Thomas, Gareth Griffiths, Natalia V Permyakova, Jacqui Nuttall, Irene Soulsby, Alison M Layton, Tracey H Sach, Sarah Pyne, Susanne Renz, Zina Eminton, Megan Lawrence

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Effectiveness of analgesic ear drops as add-on treatment to oral analgesics in children with acute otitis media: study protocol of the OPTIMA pragmatic randomised controlled trial by Paul Little, Alastair D Hay, Lucy Yardley, G Ardine de Wit, Nicolaas P A Zuithoff, Sibyl Anthierens, Roderick P Venekamp, Anne G M Schilder, Roger A M J Damoiseaux, Elisabeth A M Sanders, Saskia Hullegie, Joline L H de Sévaux

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Supporting self-management with an internet intervention for low back pain in primary care: a RCT (SupportBack 2) by Adam W A Geraghty, Taeko Becque, Lisa C Roberts, Jonathan Hill, Nadine E Foster, Lucy Yardley, Beth Stuart, David A Turner, Gareth Griffiths, Frances Webley, Lorraine Durcan, Alannah Morgan, Stephanie Hughes, Sarah Bathers, Stephanie Butler-Walley, Simon Wathall, Gemma Mansell, Malcolm White, Firoza Davies, Paul Little

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Associations between burnout and career disengagement factors among general practitioners: a path analysis by Christos Grigoroglou, Christos Grigoroglou, Mark Hann, Mark Hann, Alexander Hodkinson, Alexander Hodkinson, Salwa S. Zghebi, Evangelos Kontopantelis, Evangelos Kontopantelis, Darren M. Ashcroft, Darren M. Ashcroft, Darren M. Ashcroft, Carolyn A. Chew-Graham, Rupert A. Payne, Paul Little, Simon de Lusignan, Simon de Lusignan, Anli Yue Zhou, Aneez Esmail, Maria Panagioti, Maria Panagioti

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Patient and healthcare professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: qualitative study of the CATHETER II trial by John Norrie, Graeme Maclennan, David Cooper, Paul Little, Peter Murchie, Phyo Kyaw Myint, Mohamed Abdel-fattah, Mary Kilonzo, Muhammad Imran Omar, Diana Johnson, Sara J Maclennan, James Ndow, Graham Scotland, Amanda Young, Seonaidh Cotton, Nikesh Thiruchelvam, Catherine Paterson, Lynda Constable, Hashim Hashim, Sheela Tripathee, Konstantinos Dimitropoulos, Suzanne Evans, Karen Powell, James Hugh Larcombe

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CATHETER II: a randomised controlled trial comparing the clinical effectiveness of various washout policies versus no washout policy in preventing catheter-associated complications... by John Norrie, Graeme Maclennan, David Cooper, Paul Little, Peter Murchie, Phyo Kyaw Myint, Mohamed Abdel-fattah, Mary Kilonzo, Muhammad Imran Omar, Diana Johnson, Sara J Maclennan, James N'Dow, Graham Scotland, Amanda Young, Seonaidh Cotton, James Larcombe, Nikesh Thiruchelvam, Catherine Paterson, Lynda Constable, Hashim Hashim, Sheela Tripathee, Konstantinos Dimitropoulos, Suzanne Evans, Karen Powell

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Comparison of microbiological diagnosis of urinary tract infection in young children by routine health service laboratories and a research laboratory: Diagnostic cohort study. by Kate Birnie, Alastair D Hay, Mandy Wootton, Robin Howe, Alasdair MacGowan, Penny Whiting, Michael Lawton, Brendan Delaney, Harriet Downing, Jan Dudley, William Hollingworth, Catherine Lisles, Paul Little, Kathryn O'Brien, Timothy Pickles, Kate Rumsby, Emma Thomas-Jones, Judith Van der Voort, Cherry-Ann Waldron, Kim Harman, Kerenza Hood, Christopher C Butler, Jonathan A C Sterne

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Trial to compare mixed-use (multi-use and single-use) intermittent catheter management with single-use management over 12 months (The MultICath Trial): protocol for a non-inferiori... by Isabel Reading, Jeremy Jones, Gillian Watson, Paul Little, Michael Moore, Carl R May, Suzanne Hagen, Doreen McClurg, Karen Guerrero, Jacqui Prieto, Nina Wilson, Carol Shields, Mandy Fader, Bridget Clancy, Margaret Macaulay, Thomas J Chadwick, Brian S Buckley, Rajvinder Khasriya, Alaa Abouhajar, Catherine P James, Nicola Goudie, Sylvia Dickson, Miriam R Avery, Jackie Broadbridge, Alan Cottenden, Cathy Murphy, Anthony Timoney, Sandra A Wilks

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Internet and telephone intervention to support patients discontinuing long-term antidepressants in primary care: the REDUCE research programme including RCT by Tony Kendrick, Beth Stuart, Hannah Bowers, Mahboobeh Haji Sadeghi, Helen Page, Christopher Dowrick, Michael Moore, Mark Gabbay, Geraldine Leydon, Guiqing Lily Yao, Shihua Zhu, Paul Little, Gareth Griffiths, Glyn Lewis, Carl May, Joanna Moncrieff, Chris F Johnson, Una Macleod, Simon Gilbody, Rachel Dewar-Haggart, Samantha Williams, Wendy O’Brien, Riya Tiwari, Catherine Woods, Tasneem Patel, Naila Khan, Emma Maund, Nadja van Ginneken, Amy Din, Claire Reidy, Rebecca Lucier, Bryan Palmer, Taeko Becque, Yumna Masood, Natalie Thompson, Ellen van Leeuwen, Marta Glowacka, Adam WA Geraghty

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Canadian Adaptive Platform Trial of Treatments for COVID in Community Settings (CanTreatCOVID): protocol for a randomised controlled adaptive platform trial of treatments for acute... by Catherine Hudon, Kris Aubrey-Bassler, Vivian R Ramsden, Machelle Wilchesky, Paul Little, Michelle Greiver, Rahim Moineddin, Ryan Zarychanski, Jean-Eric Tarride, Annie Leblanc, Peter Jüni, Dee Mangin, Robert Fowler, Srinivas Murthy, Jennifer Rayner, Alexander Singer, Yoav Keynan, Simone Dahrouge, Emily Gard Marshall, Rita McCracken, Sabrina T Wong, David J A Jenkins, Kerry McBrien, Nav Persaud, Anita Srivastava, Jennifer Isenor, Todd C Lee, Christopher C Butler, John C Marshall, Stephanie Garies, Valeria E Rac, Ross E G Upshur, Peter Selby, Marie-Thérèse Lussier, Sarvesh Logsetty, Andrew David Pinto, Melissa Andrew, Brianne Wood, Emily G McDonald, Amanda Condon, Aisha Lofters, Christine Leong, Lynora Saxinger, Rachel Walsh, Abhimanyu Sud, Sylvain Lother, Jean-Sébastien Paquette, David Barber, Brendan Barrett, Rae Spiwak, Sakina Walji, Ali Damji, Banafshe Hosseini, Bruno R. da Costa, Peter Daley, Noah Crampton, Jennifer Hulme, Rosemarie Lall, Laura Maclaren, Brianna Orava, Jay Jae Hee Park, Diana C. Sanchez-Ramirez, Haolun Shi, Deanna Telner, Barb Zelek, Jolanta Piszczek, Daniel Warshafsky

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