FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells. by Kathryn Graham, Kim Moran-Jones, Owen J Sansom, Valerie G Brunton, Margaret C Frame

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Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine. by Boris Y Shorning, Joanna Zabkiewicz, Afshan McCarthy, Helen B Pearson, Douglas J Winton, Owen J Sansom, Alan Ashworth, Alan R Clarke

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Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing. by Ai Tian, Hassina Benchabane, Zhenghan Wang, Chloe Zimmerman, Nan Xin, Jessica Perochon, Gabriela Kalna, Owen J Sansom, Chao Cheng, Julia B Cordero, Yashi Ahmed

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PD‐L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy by Abul Azad, Su Yin Lim, Zenobia D'Costa, Keaton Jones, Angela Diana, Owen J Sansom, Philipp Kruger, Stanley Liu, W Gillies McKenna, Omer Dushek, Ruth J Muschel, Emmanouil Fokas

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HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation by Kevin B Myant, Patrizia Cammareri, Michael C Hodder, Jimi Wills, Alex Von Kriegsheim, Balázs Győrffy, Mamun Rashid, Simona Polo, Elena Maspero, Lynsey Vaughan, Basanta Gurung, Evan Barry, Angeliki Malliri, Fernando Camargo, David J Adams, Antonio Iavarone, Anna Lasorella, Owen J Sansom

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Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. by Andrew J Muinonen-Martin, Olivia Susanto, Qifeng Zhang, Elizabeth Smethurst, William J Faller, Douwe M Veltman, Gabriela Kalna, Colin Lindsay, Dorothy C Bennett, Owen J Sansom, Robert Herd, Robert Jones, Laura M Machesky, Michael J O Wakelam, David A Knecht, Robert H Insall

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Use of metabolic imaging to monitor heterogeneity of tumour response following therapeutic mTORC1/2 pathway inhibition by Stephanie Ling, Alex Dexter, Alan M. Race, Shreya Sharma, Gregory Hamm, Urszula M. Polanska, Rosetta Consortium Cancer Research UK, John F. Marshall, Zoltan Takats, Kevin Brindle, Mariia O. Yuneva, George Poulogiannis, Andrew D. Campbell, Owen J. Sansom, Richard J. A. Goodwin, Josephine Bunch, Simon T. Barry

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Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo. by Michael Buchert, Dimitris Athineos, Helen E Abud, Zoe D Burke, Maree C Faux, Michael S Samuel, Andrew G Jarnicki, Catherine E Winbanks, Ian P Newton, Valerie S Meniel, Hiromu Suzuki, Steven A Stacker, Inke S Näthke, David Tosh, Joerg Huelsken, Alan R Clarke, Joan K Heath, Owen J Sansom, Matthias Ernst

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An efficient and robust MRI-guided radiotherapy planning approach for targeting abdominal organs and tumours in the mouse. by Veerle Kersemans, John S Beech, Stuart Gilchrist, Paul Kinchesh, Philip D Allen, James Thompson, Ana L Gomes, Zenobia D'Costa, Luke Bird, Iain D C Tullis, Robert G Newman, Aurelien Corroyer-Dulmont, Nadia Falzone, Abul Azad, Katherine A Vallis, Owen J Sansom, Ruth J Muschel, Borivoj Vojnovic, Mark A Hill, Emmanouil Fokas, Sean C Smart

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Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling by Eoghan J. Mulholland, Hayley L. Belnoue-Davis, Gabriel N. Valbuena, Nuray Gunduz, Amelia Ligeza, Muyang Lin, Sujata Biswas, Ester Gil Vasquez, Sulochana Omwenga, Nadia Nasreddin, Michael C. Hodder, Lai Mun Wang, Aik Seng Ng, Elizabeth Jennings, Kim S. Midwood, Neesha Dedi, Shazia Irshad, Rachel A. Ridgway, Toby J. Phesse, James East, Ian PM Tomlinson, Gareth CG Davies, Owen J. Sansom, Simon J. Leedham

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