Docking 14 Million Virtual Isoquinuclidines against the μ and κ Opioid Receptors Reveals Dual Antagonists–Inverse Agonists with Reduced Withdrawal Effects by Seth F. Vigneron, Shohei Ohno, Joao Braz, Joseph Y. Kim, Oh Sang Kweon, Chase Webb, Christian B. Billesbølle, Karthik Srinivasan, Karnika Bhardwaj, John J. Irwin, Aashish Manglik, Allan I. Basbaum, Jonathan A. Ellman, Brian K. Shoichet

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