Known allosteric proteins have central roles in genetic disease. by György Abrusán, David B Ascher, Michael Inouye

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Ten simple rules to make your computing more environmentally sustainable. by Loïc Lannelongue, Jason Grealey, Alex Bateman, Michael Inouye

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Performance of deep-learning-based approaches to improve polygenic scores by Martin Kelemen, Yu Xu, Tao Jiang, Jing Hua Zhao, Carl A. Anderson, Chris Wallace, Adam Butterworth, Michael Inouye

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Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction by Ruidong Xiang, Chief Ben-Eghan, Yang Liu, David Roberts, Scott Ritchie, Samuel A. Lambert, Yu Xu, Fumihiko Takeuchi, Michael Inouye

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Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy. by Sean G Byars, Qin Qin Huang, Lesley-Ann Gray, Andrew Bakshi, Samuli Ripatti, Gad Abraham, Stephen C Stearns, Michael Inouye

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Variation and prognostic potential of the gut antibiotic resistome in the FINRISK 2002 cohort by Katariina Pärnänen, Matti O. Ruuskanen, Guilhem Sommeria-Klein, Ville Laitinen, Pyry Kantanen, Guillaume Méric, Camila Gazolla Volpiano, Michael Inouye, Rob Knight, Veikko Salomaa, Aki S. Havulinna, Teemu Niiranen, Leo Lahti

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Metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease by Carles Foguet, Xilin Jiang, Scott C Ritchie, Elodie Persyn, Yu Xu, Chief Ben-Eghan, Henry J Taylor, Emanuele Di Angelantonio, John Danesh, Adam S Butterworth, Samuel A Lambert, Michael Inouye

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Metabonomic, transcriptomic, and genomic variation of a population cohort by Michael Inouye, Johannes Kettunen, Pasi Soininen, Kaisa Silander, Samuli Ripatti, Linda S Kumpula, Eija Hämäläinen, Pekka Jousilahti, Antti J Kangas, Satu Männistö, Markku J Savolainen, Antti Jula, Jaana Leiviskä, Aarno Palotie, Veikko Salomaa, Markus Perola, Mika Ala‐Korpela, Leena Peltonen

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Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses. by Luanluan Sun, Lisa Pennells, Stephen Kaptoge, Christopher P Nelson, Scott C Ritchie, Gad Abraham, Matthew Arnold, Steven Bell, Thomas Bolton, Stephen Burgess, Frank Dudbridge, Qi Guo, Eleni Sofianopoulou, David Stevens, John R Thompson, Adam S Butterworth, Angela Wood, John Danesh, Nilesh J Samani, Michael Inouye, Emanuele Di Angelantonio

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Correction for Zhu et al., “Phylogeny-Aware Analysis of Metagenome Community Ecology Based on Matched Reference Genomes while Bypassing Taxonomy” by Qiyun Zhu, Shi Huang, Antonio Gonzalez, Imran McGrath, Daniel McDonald, Niina Haiminen, George Armstrong, Yoshiki Vázquez-Baeza, Julian Yu, Justin Kuczynski, Gregory D. Sepich-Poore, Austin D. Swafford, Promi Das, Justin P. Shaffer, Franck Lejzerowicz, Pedro Belda-Ferre, Aki S. Havulinna, Guillaume Méric, Teemu Niiranen, Leo Lahti, Veikko Salomaa, Ho-Cheol Kim, Mohit Jain, Michael Inouye, Jack A. Gilbert, Rob Knight

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Mitochondrial damage in muscle specific PolG mutant mice activates the integrated stress response and disrupts the mitochondrial folate cycle by Simon T. Bond, Emily J. King, Shannen M. Walker, Christine Yang, Yingying Liu, Kevin H. Liu, Aowen Zhuang, Aaron W. Jurrjens, Haoyun A. Fang, Luke E. Formosa, Artika P. Nath, Sergio Ruiz Carmona, Michael Inouye, Thy Duong, Kevin Huynh, Peter J. Meikle, Simon Crawford, Georg Ramm, Sheik Nadeem Elahee Doomun, David P. de Souza, Danielle L. Rudler, Anna C. Calkin, Aleksandra Filipovska, David W. Greening, Darren C. Henstridge, Brian G. Drew

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Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. by Nicole Soranzo, Fernando Rivadeneira, Usha Chinappen-Horsley, Ida Malkina, J Brent Richards, Naomi Hammond, Lisette Stolk, Alexandra Nica, Michael Inouye, Albert Hofman, Jonathan Stephens, Eleanor Wheeler, Pascal Arp, Rhian Gwilliam, P Mila Jhamai, Simon Potter, Amy Chaney, Mohammed J R Ghori, Radhi Ravindrarajah, Sergey Ermakov, Karol Estrada, Huibert A P Pols, Frances M Williams, Wendy L McArdle, Joyce B van Meurs, Ruth J F Loos, Emmanouil T Dermitzakis, Kourosh R Ahmadi, Deborah J Hart, Willem H Ouwehand, Nicholas J Wareham, Inês Barroso, Manjinder S Sandhu, David P Strachan, Gregory Livshits, Timothy D Spector, André G Uitterlinden, Panos Deloukas

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Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. by Elizabeth G Holliday, Albert V Smith, Belinda K Cornes, Gabriëlle H S Buitendijk, Richard A Jensen, Xueling Sim, Thor Aspelund, Tin Aung, Paul N Baird, Eric Boerwinkle, Ching Yu Cheng, Cornelia M van Duijn, Gudny Eiriksdottir, Vilmundur Gudnason, Tamara Harris, Alex W Hewitt, Michael Inouye, Fridbert Jonasson, Barbara E K Klein, Lenore Launer, Xiaohui Li, Gerald Liew, Thomas Lumley, Patrick McElduff, Barbara McKnight, Paul Mitchell, Bruce M Psaty, Elena Rochtchina, Jerome I Rotter, Rodney J Scott, Wanting Tay, Kent Taylor, Yik Ying Teo, André G Uitterlinden, Ananth Viswanathan, Sophia Xie, Wellcome Trust Case Control Consortium 2, Johannes R Vingerling, Caroline C W Klaver, E Shyong Tai, David Siscovick, Ronald Klein, Mary Frances Cotch, Tien Y Wong, John Attia, Jie Jin Wang

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Genetic loci for retinal arteriolar microcirculation. by Xueling Sim, Richard A Jensen, M Kamran Ikram, Mary Frances Cotch, Xiaohui Li, Stuart MacGregor, Jing Xie, Albert Vernon Smith, Eric Boerwinkle, Paul Mitchell, Ronald Klein, Barbara E K Klein, Nicole L Glazer, Thomas Lumley, Barbara McKnight, Bruce M Psaty, Paulus T V M de Jong, Albert Hofman, Fernando Rivadeneira, Andre G Uitterlinden, Cornelia M van Duijn, Thor Aspelund, Gudny Eiriksdottir, Tamara B Harris, Fridbert Jonasson, Lenore J Launer, Wellcome Trust Case Control Consortium 2, John Attia, Paul N Baird, Stephen Harrap, Elizabeth G Holliday, Michael Inouye, Elena Rochtchina, Rodney J Scott, Ananth Viswanathan, Global BPGen Consortium, Guo Li, Nicholas L Smith, Kerri L Wiggins, Jane Z Kuo, Kent D Taylor, Alex W Hewitt, Nicholas G Martin, Grant W Montgomery, Cong Sun, Terri L Young, David A Mackey, Natalie R van Zuydam, Alex S F Doney, Colin N A Palmer, Andrew D Morris, Jerome I Rotter, E Shyong Tai, Vilmundur Gudnason, Johannes R Vingerling, David S Siscovick, Jie Jin Wang, Tien Y Wong

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SARS-CoV-2 infectivity can be modulated through bacterial grooming of the glycocalyx by Cameron Martino, Benjamin P. Kellman, Daniel R. Sandoval, Thomas Mandel Clausen, Robert Cooper, Alhosna Benjdia, Feryel Soualmia, Alex E. Clark, Aaron F. Garretson, Clarisse A. Marotz, Se Jin Song, Stephen Wandro, Livia S. Zaramela, Rodolfo A. Salido, Qiyun Zhu, Erick Armingol, Yoshiki Vázquez-Baeza, Daniel McDonald, James T. Sorrentino, Bryn Taylor, Pedro Belda-Ferre, Promi Das, Farhana Ali, Chenguang Liang, Yujie Zhang, Luca Schifanella, Alice Covizzi, Alessia Lai, Agostino Riva, Christopher Basting, Courtney Ann Broedlow, Aki S. Havulinna, Pekka Jousilahti, Mehrbod Estaki, Tomasz Kosciolek, Rayus Kuplicki, Teresa A. Victor, Martin P. Paulus, Kristen E. Savage, Jennifer L. Benbow, Emma S. Spielfogel, Cheryl A. M. Anderson, Maria Elena Martinez, James V. Lacey, Shi Huang, Niina Haiminen, Laxmi Parida, Ho-Cheol Kim, Jack A. Gilbert, Daniel A. Sweeney, Sarah M. Allard, Austin D. Swafford, Susan Cheng, Michael Inouye, Teemu Niiranen, Mohit Jain, Veikko Salomaa, Karsten Zengler, Nichole R. Klatt, Jeff Hasty, Olivier Berteau, Aaron F. Carlin, Jeffrey D. Esko, Nathan E. Lewis, Rob Knight

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Novel loci and biomedical consequences of iron homoeostasis variation by Elias Allara, Steven Bell, Rebecca Smith, Spencer J. Keene, Dipender Gill, Liam Gaziano, Deisy Morselli Gysi, Feiyi Wang, Vinicius Tragante, Amy Mason, Savita Karthikeyan, R. Thomas Lumbers, Emmanuela Bonglack, Willem Ouwehand, David J. Roberts, Joseph Dowsett, Sisse Rye Ostrowski, Margit Hørup Larsen, Henrik Ullum, Ole Birger Pedersen, Søren Brunak, Karina Banasik, Christian Erikstrup, DBDS Genomic Consortium, Jonathan Mitchell, Christian Fuchsberger, Cristian Pattaro, Peter P. Pramstaller, Domenico Girelli, Mikko Arvas, Jarkko Toivonen, Sophie Molnos, Annette Peters, Ozren Polasek, Igor Rudan, Caroline Hayward, Ciara McDonnell, Nicola Pirastu, James F. Wilson, Katja van den Hurk, Franke Quee, Luigi Ferrucci, Stefania Bandinelli, Toshiko Tanaka, Giorgia Girotto, Maria Pina Concas, Alessandro Pecori, Niek Verweij, Pim van der Harst, Yordi J. van de Vegte, Lambertus A. Kiemeney, Fred C. Sweep, Tessel E. Galesloot, Patrick Sulem, Daniel Gudbjartsson, Egil Ferkingstad, FinnGen Consortium, Luc Djousse, Kelly Cho, Michael Inouye, Stephen Burgess, Beben Benyamin, Konrad Oexle, Dorine Swinkels, Kari Stefansson, Magnus Magnusson, Andrea Ganna, Michael Gaziano, Kerry Ivey, John Danesh, Alexandre Pereira, Angela M. Wood, Adam S. Butterworth, Emanuele Di Angelantonio

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