Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target. by Nutpakal Ketprasit, Chia-Wei Tai, Vivek Kumar Sharma, Yogavel Manickam, Yogesh Khandokar, Xi Ye, Con Dogovski, David H Hilko, Craig J Morton, Anne-Sophie C Braun, Michael G Leeming, Bagale Siddharam, Gerald J Shami, Pushpangadan Indira Pradeepkumar, Santosh Panjikar, Sally-Ann Poulsen, Michael D W Griffin, Amit Sharma, Leann Tilley, Stanley C Xie

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A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo. by Stanley C Xie, Chia-Wei Tai, Craig J Morton, Liting Ma, Shih-Chung Huang, Sergio Wittlin, Yawei Du, Yongbo Hu, Con Dogovski, Mina Salimimarand, Robert Griffin, Dylan England, Elisa de la Cruz, Ioanna Deni, Tomas Yeo, Anna Y Burkhard, Josefine Striepen, Kyra A Schindler, Benigno Crespo, Francisco J Gamo, Yogesh Khandokar, Craig A Hutton, Tayla Rabie, Lyn-Marié Birkholtz, Mufuliat T Famodimu, Michael J Delves, Judith Bolsher, Karin M J Koolen, Rianne van der Laak, Anna C C Aguiar, Dhelio B Pereira, Rafael V C Guido, Darren J Creek, David A Fidock, Lawrence R Dick, Stephen L Brand, Alexandra E Gould, Steven Langston, Michael D W Griffin, Leann Tilley

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