Comparing viral, bacterial, and coinfections in community-acquired pneumonia, a retrospective cohort study by Frederike Waldeck, Solveig Lemmel, Marcus Panning, Nadja Käding, Andreas Essig, Gernot Rohde, Mathias W. Pletz, Martin Witzenrath, Sebastien Boutin, Jan Rupp

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The impact of the SARS-CoV-2 pandemic on the prevalence of respiratory tract pathogens in patients with community-acquired pneumonia in Germany by Theo Dähne, Wolfgang Bauer, Andreas Essig, Bernhard Schaaf, Christoph D. Spinner, Mathias W. Pletz, Gernot Rohde, Jan Rupp, Martin Witzenrath, Marcus Panning

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Biomarkers troponin and procalcitonin in addition to CRB-65 enhance risk stratification in patients with community-acquired pneumonia by Imrana Farhat, Maciej Rosolowski, Katharina Ahrens, Jasmin Lienau, Peter Ahnert, Mathias Pletz, Gernot Rohde, Jan Rupp, Markus Scholz, Martin Witzenrath, the CAPNETZ Study Group

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Clinical safety and pharmacokinetics of a novel oral niclosamide formulation compared with marketed niclosamide chewing tablets in healthy volunteers: A three-part randomized, doub... by Niklas Walther, Robert Schultz-Heienbrok, Heino Staß, Victor M Corman, Nils C Gassen, Marcel A Müller, Christian Drosten, Martin Witzenrath, Hweeling Lee, Maximilian G Posch

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Impact of comorbidities and personal characteristics on weather-related risk for community-acquired pneumonia by Thomas Brenner, Ann-Christine Link, Saeed A. Khan, Christoph Reudenbach, Joerg Bendix, Max Kutzinski, Max Kutzinski, Barbara C. Weckler, Barbara C. Weckler, Hendrik Pott, Hendrik Pott, Jan Rupp, Jan Rupp, Martin Witzenrath, Martin Witzenrath, Gernot Rohde, Gernot Rohde, Mathias W. Pletz, Mathias W. Pletz, Mathias W. Pletz, Wilhelm Bertrams, Bernd Schmeck, Bernd Schmeck, Bernd Schmeck, Bernd Schmeck

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Adjunctive phage therapy improves antibiotic treatment of ventilator-associated-pneumonia with Pseudomonas aeruginosa by Chantal Weissfuss, Jingjing Li, Ulrike Behrendt, Karen Hoffmann, Magdalena Bürkle, Chunjiang Tan, Gopinath Krishnamoorthy, Imke H. E. Korf, Christine Rohde, Baptiste Gaborieau, Laurent Debarbieux, Jean-Damien Ricard, Martin Witzenrath, Matthias Felten, Geraldine Nouailles

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Clinical improvements after endoscopic lung volume reduction with valves in patients with advanced emphysema and a 6-min walk test ≤140 m at baseline by Jacopo Saccomanno, Lara Kilic, Thomas Sgarbossa, Konrad Neumann, Franz Stanzel, Angelique Holland, Christian Grah, Wolfgang Gesierich, Joanna Krist, Joachim H. Ficker, Stephan Eggeling, Stefan Andreas, Bernd Schmidt, Stephan Eisenmann, Björn Schwick, Karl-Josef Franke, Andreas Fertl, Martin Witzenrath, Ralf-Harto Hübner

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Managing withdrawals and exclusions of study participants in COVID-19-research by NUKLEUS by Heike Valentin, Henriette Rau, Lizon Fiedler-Lacombe, Arne Blumentritt, Ekaterina Heim, Alexander Rudolph, Katrin Leyh, Monika Kraus, Bettina Lorenz-Depiereux, Irina Chaplinskaya, Christian Schäfer, Jens Schaller, Joerg Janne Vehreschild, Melanie Stecher, Margarete Scherer, Martin Witzenrath, Beate Balzuweit, Stefan Schreiber, Thomas Bahmer, Wolfgang Lieb, Steffen Cordes, Wolfgang Hoffmann, Sabine Hanß, Dana Stahl

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IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid. by Jan Naujoks, Christoph Tabeling, Brian D Dill, Christine Hoffmann, Andrew S Brown, Mareike Kunze, Stefan Kempa, Andrea Peter, Hans-Joachim Mollenkopf, Anca Dorhoi, Olivia Kershaw, Achim D Gruber, Leif E Sander, Martin Witzenrath, Susanne Herold, Andreas Nerlich, Andreas C Hocke, Ian van Driel, Norbert Suttorp, Sammy Bedoui, Hubert Hilbi, Matthias Trost, Bastian Opitz

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DNA methylation changes during acute COVID-19 are associated with long-term transcriptional dysregulation in patients’ airway epithelial cells by Marey Messingschlager, Sebastian D Mackowiak, Maria Theresa Voelker, Matthias Bieg, Jennifer Loske, Robert Lorenz Chua, Johannes Liebig, Sören Lukassen, Loreen Thürmann, Anke Seegebarth, Sven Twardziok, Daria Doncevic, Carl Herrmann, Stephan Lorenz, Sven Klages, Fridolin Steinbeis, Martin Witzenrath, Florian Kurth, Christian Conrad, Leif E Sander, Naveed Ishaque, Roland Eils, Irina Lehmann, Sven Laudi, Saskia Trump

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Multicentre pragmatic embedded stepped wedge cluster randomised trial comparing glucose 5% with sodium chloride 0.9% as the default drug diluent in the ICU: the sweet-water trial p... by Alexander Zarbock, Kai-Uwe Eckardt, Claudia Spies, Felix Balzer, Martin Witzenrath, Philipp Enghard, Björn Tampe, Oliver Hunsicker, Steffen Weber-Carstens, Bjoern Weiss, Jens Nee, Christian Strauss, Heiko Schenk, Jan-Hendrik Bernhard Hardenberg, Ricarda Merle Hinz, Mareen Pigorsch, Alexander Uhrig, Holger Müller-Redetzky, Tim Schroeder, Ulrike Trost, Daniel Zickler, Rainer Borgstedt, Mariam Abu-Tair, Uta Hildebrand, Dario von Wedel

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Genome-wide association study of post COVID-19 syndrome in a population-based cohort in Germany by Anne-Kathrin Ruß, Stefan Schreiber, Wolfgang Lieb, J. Janne Vehreschild, Peter U. Heuschmann, Thomas Illig, Katharina S. Appel, Maria J. G. T. Vehreschild, Dagmar Krefting, Lennart Reinke, Alin Viebke, Susanne Poick, Stefan Störk, Jens-Peter Reese, Thomas Zoller, Lilian Krist, David Ellinghaus, Bärbel U. Foesel, Christian Gieger, Bettina Lorenz-Depiereux, Martin Witzenrath, Gabriele Anton, Michael Krawczak, Jan Heyckendorf, Thomas Bahmer

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A proteomic survival predictor for COVID-19 patients in intensive care. by Vadim Demichev, Pinkus Tober-Lau, Tatiana Nazarenko, Oliver Lemke, Simran Kaur Aulakh, Harry J Whitwell, Annika Röhl, Anja Freiwald, Mirja Mittermaier, Lukasz Szyrwiel, Daniela Ludwig, Clara Correia-Melo, Lena J Lippert, Elisa T Helbig, Paula Stubbemann, Nadine Olk, Charlotte Thibeault, Nana-Maria Grüning, Oleg Blyuss, Spyros Vernardis, Matthew White, Christoph B Messner, Michael Joannidis, Thomas Sonnweber, Sebastian J Klein, Alex Pizzini, Yvonne Wohlfarter, Sabina Sahanic, Richard Hilbe, Benedikt Schaefer, Sonja Wagner, Felix Machleidt, Carmen Garcia, Christoph Ruwwe-Glösenkamp, Tilman Lingscheid, Laure Bosquillon de Jarcy, Miriam S Stegemann, Moritz Pfeiffer, Linda Jürgens, Sophy Denker, Daniel Zickler, Claudia Spies, Andreas Edel, Nils B Müller, Philipp Enghard, Aleksej Zelezniak, Rosa Bellmann-Weiler, Günter Weiss, Archie Campbell, Caroline Hayward, David J Porteous, Riccardo E Marioni, Alexander Uhrig, Heinz Zoller, Judith Löffler-Ragg, Markus A Keller, Ivan Tancevski, John F Timms, Alexey Zaikin, Stefan Hippenstiel, Michael Ramharter, Holger Müller-Redetzky, Martin Witzenrath, Norbert Suttorp, Kathryn Lilley, Michael Mülleder, Leif Erik Sander, PA-COVID-19 Study group, Florian Kurth, Markus Ralser

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Regional comparison of efficacy and safety for vilobelimab in critically ill, invasively mechanically ventilated COVID-19 patients by Gernot Marx, Antoine Roquilly, Tobias Welte, Jean Dellamonica, Greet Hermans, Martin Witzenrath, Michael Bauer, Matthias Gründling, Ulrich Jaschinski, Robert Zerbib, Djillali Annane, Matthijs C Brouwer, Bruno Mourvillier, Jean Baptiste Lascarrou, Francis Schneider, Guillaume Thiéry, Diederik van de Beek, Carole Schwebel, Fabio S. Taccone, Luc Desmedt, Claire Dupuis, Pieter van Paassen, Michael Piagnerelli, Endry H T Lim, Sanne de Bruin, Simon Rückinger, Claus Thielert, Renfeng Guo, Bruce P Burnett, Camilla Chong, Niels C Riedemann, Alexander P Vlaar, Alexander P. J. Vlaar, Leo M. A. Heunks, Sanne de Bruin, Endry H. T. Lim, Matthijs C. Brouwer, Pieter R. Tuinman, José Francisco K. Saraiva, Suzana M. Lobo, Rodrigo Boldo, Jesus A. Simon-Campos, Alexander D. Cornet, Anastasia Grebenyuk, Johannes M. Engelbrecht, Murimisi Mukansi, Philippe G. Jorens, Korinna Pilz, Diederik van de Beek, Niels C. Riedemann, Pierre Bulpa, Marc Diltoer, Nikolaas De Neve, Antonio T. Freire, Felipe D. Pizzol, Anna Karolina Marinho, Victor H. Sato, Clovis Arns da Cunha, Mathilde Neuville, Jean Luc Diehl, Jean Paul Mira, Marc Berger, Klaus Matschke, Roberto Mercado-Longoria, Belinda Gomez Quintana, Jorge Alberto Zamudio-Lerma

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Building an international precision medicine platform trial for the acute respiratory distress syndrome (ARDS): an expert consensus project report by Kiran Reddy, Neil Aggarwal, Narges Alipanah-Lechner, Djillali Annane, David B Antcliffe, Daphne Babalis, J Kenneth Baillie, Abigail Beane, Lieuwe DJ Bos, Aidan Burrell, Carolyn S Calfee, Kiki Cano-Gamez, Victoria R Cornelius, Mary Cross, Emma Davenport, Lorenzo del Sorbo, Laura Esserman, Eddy Fan, Vito Fanelli, Niall D Ferguson, D Clark Files, Christoph Fisser, Shigeki Fujitani, Ewan C Goligher, Anthony C Gordon, Giacomo Grasselli, Fergus Hamilton, Rashan Haniffa, Andrea Haren, Daniel JR Harvey, Leanne M Hays, Anna Heath, Nicholas Heming, Susanne Herold, Tim Hicks, Nao Ichihara, Vinod Jaiswal, Jun Kataoka, Julian C Knight, Patrick R Lawler, Kathleen Liu, John C Marshall, David M Maslove, Michael A Matthay, Daniel F McAuley, Nuala J Meyer, Jonathan A Millar, Holger Müller-Redetzky, Alistair Nichol, John Norrie, Marlies Ostermann, Andrew Owen, Cecilia M O’Kane, Dhruv Parekh, Rachel Phillips, Duncan Richards, Bram Rochwerg, Anthony J Rostron, Hiroki Saito, Romit J Samanta, Vittorio Scaravilli, Wesley Self, Manu Shankar-Hari, A John Simpson, Pratik Sinha, Marry R Smit, Jonathan Stewart, B Taylor Thompson, István Vadász, Ed Waddingham, Steve Webb, Graham Wheeler, D Martin Witzenrath, Mark M Wurfel, Thomas R Martin

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