CAR-T cell therapy for cancer: current challenges and future directions by Inés Zugasti, Lady Espinosa-Aroca, Klaudyna Fidyt, Vladimir Mulens-Arias, Marina Diaz-Beya, Manel Juan, Álvaro Urbano-Ispizua, Jordi Esteve, Talia Velasco-Hernandez, Pablo Menéndez

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Effects of Live and Peptide-Based Antimicrobiota Vaccines on <i>Ixodes ricinus</i> Fitness, Microbiota, and Acquisition of Tick-Borne Pathogens by Apolline Maitre, Lourdes Mateos-Hernandez, Myriam Kratou, Natalia Egri, Jennifer Maye, Manel Juan, Adnan Hodžić, Dasiel Obregón, Lianet Abuin-Denis, Elianne Piloto-Sardinas, Andrea C. Fogaça, Alejandro Cabezas-Cruz

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Preclinical development of three novel CARs targeting CD79b for the treatment of non-Hodgkin’s lymphoma and characterization of the loss of the target antigen by Manel Juan, Beatriz Martín-Antonio, Pablo Engel, Narcis Fernandez-Fuentes, Esperanza Esquinas, Alvaro Moreno-Sanz, Victor Sandá, Damian Stodulski-Ciesla, Jennifer Borregón, Virginia Peña-Blanque, Javier Fernández-Calles, Juana Serrano-Lopez, Pilar Llamas-Sillero, Laura Solán-Blanco

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Discovery and validation of frameshift-derived neopeptides in Lynch syndrome: paving the way for novel cancer prevention strategies by Marta Pineda, Sabela Carballal, María Pellisé, Liseth Rivero, Francesc Balaguer, Fátima Marín, Leticia Moreira, Teresa Ocaña, Manel Juan, Daniel Benitez-Ribas, Georgina Flórez-Grau, Joaquín Castillo-Iturra, Cristina Bayó, Giancarlo Castellano, Hardeep Kumari, Maria Daca-Alvarez, Oswaldo Ortiz, Rebeca Moreira, Julia Canet-Hermida, Capella Gabriel

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Discovery of a pan anti-SARS-CoV-2 monoclonal antibody with highly efficient infected cell killing capacity for novel immunotherapeutic approaches by Daouda Abba Moussa, Mario Vazquez, Christine Chable-Bessia, Vincent Roux-Portalez, Elia Tamagnini, Mattia Pedotti, Luca Simonelli, Giang Ngo, Manon Souchard, Sebastien Lyonnais, Myriam Chentouf, Nathalie Gros, Soledad Marsile-Medun, Heiko Dinter, Martine Pugnière, Pierre Martineau, Luca Varani, Manel Juan, Hugo Calderon, Mar Naranjo-Gomez, Mireia Pelegrin

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Non-small cell lung cancer and the tumor microenvironment: making headway from targeted therapies to advanced immunotherapy by Anna De Lucia, Lucia Mazzotti, Lucia Mazzotti, Anna Gaimari, Anna Gaimari, Matteo Zurlo, Roberta Maltoni, Claudio Cerchione, Sara Bravaccini, Angelo Delmonte, Lucio Crinò, Patricia Borges de Souza, Luigi Pasini, Fabio Nicolini, Fabrizio Bianchi, Manel Juan, Hugo Calderon, Chiara Magnoni, Chiara Magnoni, Luca Gazzola, Luca Gazzola, Paola Ulivi, Massimiliano Mazza

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LRRK2-mutant microglia and neuromelanin synergize to drive dopaminergic neurodegeneration in an iPSC-based Parkinson’s disease model by Lucas Blasco-Agell, Meritxell Pons-Espinal, Veronica Testa, Gerard Roch, Jara Montero-Muñoz, Irene Fernandez-Carasa, Valentina Baruffi, Marta Gonzalez-Sepulveda, Yvonne Richaud-Patin, Senda Jimenez, Thais Cuadros, Joana M. Cladera-Sastre, Joan Compte, Zoe Manglano-Artuñedo, Salvador Ventura, Manel Juan, Eduardo Tolosa, Angel Raya, Miquel Vila, Antonella Consiglio

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TIGIT blockade in the context of BCMA-CART cell therapy does not augment efficacy in a multiple myeloma mouse model by Aina Oliver-Caldes, Joan Mañe Pujol, Anthony M. Battram, Lorena Perez-Amill, Mireia Bachiller, Hugo Calderon, Maria Castella, Judit Carpio, Sergi V. Salsench, Natalia Tovar, Oriol Cardus, Alvaro Urbano-Ispizua, David F. Moreno, Luis Gerardo Rodríguez-Lobato, Ester Lozano, Laura Rosiñol, Manel Juan, Beatriz Martín-Antonio, Carlos Fernández de Larrea

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Alterations of the IKZF1-IKZF2 tandem in immune cells of schizophrenia patients regulate associated phenotypes by Iván Ballasch, Laura López-Molina, Marcos Galán-Ganga, Anna Sancho-Balsells, Irene Rodríguez-Navarro, Sara Borràs-Pernas, M. Angeles Rabadan, Wanqi Chen, Carlota Pastó-Pellicer, Francesca Flotta, Wang Maoyu, Joaquín Fernández-Irigoyen, Enrique Santamaría, Ruth Aguilar, Carlota Dobaño, Natalia Egri, Carla Hernandez, Miqueu Alfonso, Manel Juan, Jordi Alberch, Daniel del Toro, Belén Arranz, Josep M. Canals, Albert Giralt

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A data management system for precision medicine. by John J L Jacobs, Inés Beekers, Inge Verkouter, Levi B Richards, Alexandra Vegelien, Lizan D Bloemsma, Vera A M C Bongaerts, Jacqueline Cloos, Frederik Erkens, Patrycja Gradowska, Simon Hort, Michael Hudecek, Manel Juan, Anke H Maitland-van der Zee, Sergio Navarro-Velázquez, Lok Lam Ngai, Qasim A Rafiq, Carmen Sanges, Jesse Tettero, Hendrikus J A van Os, Rimke C Vos, Yolanda de Wit, Steven van Dijk

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Clinical impact of [18F]FDG-PET/CT in ARI0002h treatment, a CAR-T against BCMA for relapsed/refractory multiple myeloma by Inés Zugasti, Marta Tormo-Ratera, Aina Oliver-Caldés, Juan Carlos Soler-Perromat, Verónica González-Calle, David F. Moreno, Valentín Cabañas, Nieves López-Muñoz, Álvaro Bartolomé-Solanas, Marta Español-Rego, Juan Luis Reguera-Ortega, Laura Rosiñol, Lucía López-Corral, Natalia Tovar, Luis Gerardo Rodríguez-Lobato, Rosa Maria Alvarez Perez, Sara Varea, Eulàlia Olesti, Adolfo Gomez-Grande, Laura Frutos, Pilar Tamayo, Manel Juan, José M. Moraleda, Álvaro Urbano-Ispizua, E. Azucena González-Navarro, Joaquín Martínez-López, Maria-Victoria Mateos, Xavier Tomás, Xavier Setoain, Carlos Fernández de Larrea

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