Dietary restriction in Drosophila: delayed aging or experimental artefact? by Matthew D W Piper, Linda Partridge

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Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1. by Colin Selman, Linda Partridge, Dominic J Withers

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Calories do not explain extension of life span by dietary restriction in Drosophila. by William Mair, Matthew D W Piper, Linda Partridge

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Molecular evolution and functional characterization of Drosophila insulin-like peptides. by Sebastian Grönke, David-Francis Clarke, Susan Broughton, T Daniel Andrews, Linda Partridge

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Lowered insulin signalling ameliorates age-related sleep fragmentation in Drosophila. by Athanasios Metaxakis, Luke S Tain, Sebastian Grönke, Oliver Hendrich, Yvonne Hinze, Ulrike Birras, Linda Partridge

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Loss of Pol III repressor Maf1 in neurons promotes longevity by preventing the age-related decline in 5S rRNA and translation by Bowen Xu, Alexander Hull, Olivia N. M. Hill, Naja Kobal, Enric Ureña, Linda Partridge, Nazif Alic

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Loss of Pol III repressor Maf1 in neurons promotes longevity by preventing the age-related decline in 5S rRNA and translation. by Bowen Xu, Alexander Hull, Olivia N M Hill, Naja Kobal, Enric Ureña, Linda Partridge, Nazif Alic

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A novel computational approach for predicting complex phenotypes in Drosophila (starvation-sensitive and sterile) by deriving their gene expression signatures from public data. by Dobril K Ivanov, Gerrit Bostelmann, Benoit Lan-Leung, Julie Williams, Linda Partridge, Valentina Escott-Price, Janet M Thornton

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No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects. by Janne M Toivonen, Glenda A Walker, Pedro Martinez-Diaz, Ivana Bjedov, Yasmine Driege, Howard T Jacobs, David Gems, Linda Partridge

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Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease. by Oyinkan Sofola, Fiona Kerr, Iain Rogers, Richard Killick, Hrvoje Augustin, Carina Gandy, Marcus J Allen, John Hardy, Simon Lovestone, Linda Partridge

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Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk. by Cathy Slack, Christian Werz, Daniela Wieser, Nazif Alic, Andrea Foley, Hugo Stocker, Dominic J Withers, Janet M Thornton, Ernst Hafen, Linda Partridge

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A proteomic atlas of insulin signalling reveals tissue‐specific mechanisms of longevity assurance by Luke S Tain, Robert Sehlke, Chirag Jain, Manopriya Chokkalingam, Nagarjuna Nagaraj, Paul Essers, Mark Rassner, Sebastian Grönke, Jenny Froelich, Christoph Dieterich, Matthias Mann, Nazif Alic, Andreas Beyer, Linda Partridge

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Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila. by Ivana Bjedov, Helena M Cochemé, Andrea Foley, Daniela Wieser, Nathaniel S Woodling, Jorge Iván Castillo-Quan, Povilas Norvaisas, Celia Lujan, Jennifer C Regan, Janne M Toivonen, Michael P Murphy, Janet Thornton, Kerri J Kinghorn, Thomas P Neufeld, Filipe Cabreiro, Linda Partridge

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Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease. by Fiona Kerr, Oyinkan Sofola-Adesakin, Dobril K Ivanov, Jemma Gatliff, Beatriz Gomez Perez-Nievas, Hélène C Bertrand, Pedro Martinez, Rebecca Callard, Inge Snoeren, Helena M Cochemé, Jennifer Adcott, Mobina Khericha, Jorge Iván Castillo-Quan, Geoffrey Wells, Wendy Noble, Janet Thornton, Linda Partridge

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MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals. by Anna Wredenberg, Marie Lagouge, Ana Bratic, Metodi D Metodiev, Henrik Spåhr, Arnaud Mourier, Christoph Freyer, Benedetta Ruzzenente, Luke Tain, Sebastian Grönke, Francesca Baggio, Christian Kukat, Elisabeth Kremmer, Rolf Wibom, Paola Loguercio Polosa, Bianca Habermann, Linda Partridge, Chan Bae Park, Nils-Göran Larsson

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A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons by Benedikt V. Hölbling, Yashica Gupta, Paolo M. Marchi, Magda L. Atilano, Michael Flower, Enric Ureña, Rajkumar A. Goulden, Hannah K. Dobbs, Eszter Katona, Alla Mikheenko, Ashling Giblin, Ali Raza Awan, Chloe L. Fisher-Ward, Niamh O'Brien, Deniz Vaizoglu, Liam Kempthorne, Katherine M. Wilson, Lauren M. Gittings, Mireia Carcolé, Marc-David Ruepp, Sarah Mizielinska, Linda Partridge, Pietro Fratta, Sarah J. Tabrizi, Bhuvaneish T. Selvaraj, Siddharthan Chandran, Emma Armstrong, Paul Whiting, Adrian M. Isaacs

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G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo by Roberto Simone, Rubika Balendra, Thomas G Moens, Elisavet Preza, Katherine M Wilson, Amanda Heslegrave, Nathan S Woodling, Teresa Niccoli, Javier Gilbert‐Jaramillo, Samir Abdelkarim, Emma L Clayton, Mica Clarke, Marie‐Therese Konrad, Andrew J Nicoll, Jamie S Mitchell, Andrea Calvo, Adriano Chio, Henry Houlden, James M Polke, Mohamed A Ismail, Chad E Stephens, Tam Vo, Abdelbasset A Farahat, W David Wilson, David W Boykin, Henrik Zetterberg, Linda Partridge, Selina Wray, Gary Parkinson, Stephen Neidle, Rickie Patani, Pietro Fratta, Adrian M Isaacs

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