Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells. by Maria Teresa Vento, Valeria Zazzu, Alessia Loffreda, Justin R Cross, Julian Downward, Maria Patrizia Stoppelli, Ingram Iaccarino

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Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo. by Véronique Calleja, Damien Alcor, Michel Laguerre, Jongsun Park, Borivoj Vojnovic, Brian A Hemmings, Julian Downward, Peter J Parker, Banafshé Larijani

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Efficient Genotyping of KRAS Mutant Non-Small Cell Lung Cancer Using a Multiplexed Droplet Digital PCR Approach. by Alexandra Pender, Isaac Garcia-Murillas, Sareena Rana, Rosalind J Cutts, Gavin Kelly, Kerry Fenwick, Iwanka Kozarewa, David Gonzalez de Castro, Jaishree Bhosle, Mary O'Brien, Nicholas C Turner, Sanjay Popat, Julian Downward

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An oligoclonal antibody durably overcomes resistance of lung cancer to third‐generation EGFR inhibitors by Maicol Mancini, Hilah Gal, Nadège Gaborit, Luigi Mazzeo, Donatella Romaniello, Tomer Meir Salame, Moshit Lindzen, Georg Mahlknecht, Yehoshua Enuka, Dominick GA Burton, Lee Roth, Ashish Noronha, Ilaria Marrocco, Dan Adreka, Raya Eilam Altstadter, Emilie Bousquet, Julian Downward, Antonio Maraver, Valery Krizhanovsky, Yosef Yarden

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Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α by Mohamed Ismail, Stephen R. Martin, Roger George, Francesca Houghton, Geoff Kelly, Raphaël A. G. Chaleil, Panayiotis Anastasiou, Xinyue Wang, Nicola O’Reilly, Stefania Federico, Dhira Joshi, Hemavathi Nagaraj, Rachel Cooley, Ning Sze Hui, Miriam Molina-Arcas, David C. Hancock, Ali Tavassoli, Julian Downward

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PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. by Alison Wood-Kaczmar, Sonia Gandhi, Zhi Yao, Andrey Y Abramov, Erik A Miljan, Gregory Keen, Lee Stanyer, Iain Hargreaves, Kristina Klupsch, Emma Deas, Julian Downward, Louise Mansfield, Parmjit Jat, Joanne Taylor, Simon Heales, Michael R Duchen, David Latchman, Sarah J Tabrizi, Nicholas W Wood

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RAS–p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation by Alejandro Rosell, Agata Adelajda Krygowska, Marta Alcón Pérez, Cristina Cuesta, Mathieu-Benoit Voisin, Juan de Paz, Héctor Sanz-Fraile, Vinothini Rajeeve, Ana Carreras-González, Alberto Berral-González, Ottilie Swinyard, Enrique Gabandé-Rodríguez, Julian Downward, Jordi Alcaraz, Juan Anguita, Carmen García-Macías, Javier De Las Rivas, Pedro R Cutillas, Esther Castellano Sanchez

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