Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials. by Manoj M Lalu, Lauralyn McIntyre, Christina Pugliese, Dean Fergusson, Brent W Winston, John C Marshall, John Granton, Duncan J Stewart, Canadian Critical Care Trials Group

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Caspase-8: Arbitrating Life and Death in the Innate Immune System by Sahil Gupta, Monica Aida Lopez, Amin M. Ektesabi, James N. Tsoporis, Chirag M. Vaswani, Shil Y. Gandhi, Gregory D. Fairn, Claudia C. Dos Santos, John C. Marshall

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Core socioDemographic data variables in ICU Trials (CoDe-IT): a protocol for generating core data variables using a Delphi consensus process by Sangeeta Mehta, Srinivas Murthy, Karen E A Burns, Kirsten Fiest, John C Marshall, Fatima Sheikh, Alya Heirali, Karla D Krewulak, Katie O'Hearn, Kristine Russell, Scotty Kupsch, Christina Maratta

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Study protocol for a multicentre, prospective cohort study of the association of angiotensin II type 1 receptor blockers on outcomes of coronavirus infection by Joel Singer, Srinivas Murthy, Bin Du, Terry Lee, Michael O Harhay, John C Marshall, Zhiyong Peng, James A. Russell, Arthur Slutsky, Dave Sweet, David M Patrick, Matthew Cheng, Kevin D Burns

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Co-designing and pilot-testing an infographic to support the consent process in an adaptive platform trial for adults in ICU with community-acquired pneumonia or COVID-19: a mixed... by Heather K. O’Grady, Kathy Smith, Sandra Dalziel, Barbara Dolanjski, Gyan Sandhu, Marlene Santos, Jackie Bosch, Lyn S. Turkstra, Srinivas Murthy, John C. Marshall, Michelle E. Kho, for the Canadian Critical Care Trials Group

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Robustness and Mechanisms of the Atmospheric Response Over the Southern Ocean to Idealized Freshwater Input Around Antarctica by Xiaoqi Xu, Torge Martin, Rebecca L. Beadling, Jiping Liu, Sabine Bischof, Tore Hattermann, Wenjuan Huo, Qian Li, John C. Marshall, Morven Muilwijk, Andrew G. Pauling, Ariaan Purich, Inga J. Smith, Neil C. Swart, Max Thomas

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Association between tocilizumab, sarilumab and all-cause mortality at 28 days in hospitalised patients with COVID-19: A network meta-analysis. by Peter J Godolphin, David J Fisher, Lindsay R Berry, Lennie P G Derde, Janet V Diaz, Anthony C Gordon, Elizabeth Lorenzi, John C Marshall, Srinivas Murthy, Manu Shankar-Hari, Jonathan A C Sterne, Jayne F Tierney, Claire L Vale

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Publisher Correction: A machine learning and centrifugal microfluidics platform for bedside prediction of sepsis by Lidija Malic, Peter G. Y. Zhang, Pamela J. Plant, Liviu Clime, Christina Nassif, Dillon Da Fonte, Evan E. Haney, Byeong-Ui Moon, Victor Mun-Sing Sit, Daniel Brassard, Maxence Mounier, Eryn Churcher, James T. Tsoporis, Reza Falsafi, Manjeet Bains, Andrew Baker, Uriel Trahtemberg, Ljuboje Lukic, John C. Marshall, Matthias Geissler, Robert E. W. Hancock, Teodor Veres, Claudia C. dos Santos

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Identifying biomarker-driven subphenotypes of cardiogenic shock: analysis of prospective cohorts and randomized controlled trialsResearch in context by Sabri Soussi, Tuukka Tarvasmäki, Antoine Kimmoun, Mojtaba Ahmadiankalati, Feriel Azibani, Claudia C. dos Santos, Kevin Duarte, Etienne Gayat, Jacob C. Jentzer, Veli-Pekka Harjola, Benjamin Hibbert, Christian Jung, Lassus Johan, Bruno Levy, Zihang Lu, Patrick R. Lawler, John C. Marshall, Janine Pöss, Malha Sadoune, Alexis Nguyen, Alexandre Raynor, Katell Peoc'h, Holger Thiele, Rebecca Mathew, Alexandre Mebazaa

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A machine learning and centrifugal microfluidics platform for bedside prediction of sepsis by Lidija Malic, Peter G. Y. Zhang, Pamela J. Plant, Liviu Clime, Christina Nassif, Dillon Da Fonte, Evan E. Haney, Byeong-Ui Moon, Victor Mun-Sing Sit, Daniel Brassard, Maxence Mounier, Eryn Churcher, James T. Tsoporis, Reza Falsafi, Manjeet Bains, Andrew Baker, Uriel Trahtemberg, Ljuboje Lukic, John C. Marshall, Matthias Geissler, Robert E. W. Hancock, Teodor Veres, Claudia C. dos Santos

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Therapeutic-dose heparin combined with antiplatelets in noncritically ill patients with COVID-19: a secondary analysis of a multiplatform randomized controlled trial by Sylvain A. Lother, Wen Teng, Olawale Ayilara, Brett L. Houston, Barret Rush, Srinivas Murthy, Jose C. Nicolau, Lindsay Bond, Alexis F. Turgeon, John C. Marshall, Jonathan Paul, Judith S. Hochman, Matthew D. Neal, Michael E. Farkouh, Joel Nkosi, Donald S. Houston, Charlotte A. Bradbury, Asher A. Mendelson, Ewan C. Goligher, Allan Garland, Robert Balshaw, Souradet Y. Shaw, Patrick R. Lawler, Yoav Keynan, Ryan Zarychanski

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Complex Thrombo-Inflammatory Responses versus Outcomes of Non-COVID-19 Community-Acquired Pneumonia and COVID-19 by Greg Haljan, Terry Lee, Anne McCarthy, Juthaporn Cowan, Jennifer Tsang, Francois Lelouche, Alexis F. Turgeon, Patrick Archambault, Francois Lamontagne, Robert Fowler, Jennifer Yoon, Peter Daley, Matthew P. Cheng, Donald C. Vinh, Todd C. Lee, Karen C. Tran, Brent W. Winston, Hyejin Julia Kong, John H. Boyd, Keith R. Walley, Allison McGeer, David M. Maslove, John C. Marshall, Joel Singer, Fagun Jain, James A. Russell

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Community versus academic hospital community-acquired pneumonia patients: a nested cohort study by Jennifer L.Y. Tsang, Kian Rego, Alexandra Binnie, Terry Lee, Anne Mccarthy, Juthaporn Cowan, Patrick Archambault, Francois Lellouche, Alexis F. Turgeon, Jennifer Yoon, Francois Lamontagne, Allison Mcgeer, Josh Douglas, Peter Daley, Robert Fowler, David M. Maslove, Brent W. Winston, Todd C. Lee, Karen C. Tran, Matthew P. Cheng, Donald C. Vinh, John H. Boyd, Keith R. Walley, Joel Singer, John C. Marshall, Gregory Haljan, Fagun Jain, James A. Russell, For CAPTIVATE Investigators

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Clinical evaluation of adults undergoing elective surgery utilizing intraoperative incisional wound irrigation (CLEAN Wound): protocol for a randomised controlled trial by Nick Daneman, Dean A Fergusson, David Gomez, Ahmed Kayssi, Erin Lillie, Stephanie A Mason, Jad Abou Khalil, Avery B Nathens, Megan Delisle, Kelly Vogt, David E Smith, John C Marshall, George Tomlinson, Grace Ma, Sameer S Apte, Sean Bennett, Andrew J Smith, Paul Jack Karanicolas, Rachel Roke, Melanie Tsang, Pablo E. Serrano, Karim Shiraz Ladha, Erin Kennedy, Yidi Jiang, Jonah Shiroky, Sudarshani Puran, Brian Pinchuk, Tyler Lamb, Kenneth Leslie, Dorotea Mutabdzic, Shahnoor M Ullah, Jessica Holland, Michael Calderone, Judith Herriott, Ed Voltan, Barbara Sloan, Hala Muaddi, C. David Mazer, Mary-Anne Aarts

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Machine Learning Accurately Predicts Need for Critical Care Support in Patients Admitted to Hospital for Community-Acquired Pneumonia by George S. Chen, BSc, Terry Lee, PhD, Jennifer L.Y. Tsang, MD, Alexandra Binnie, MD, Anne McCarthy, MD, Juthaporn Cowan, MD, Patrick Archambault, MD, Francois Lellouche, MD, Alexis F. Turgeon, MD, MSc, Jennifer Yoon, MD, Francois Lamontagne, MD, Allison McGeer, MD, Josh Douglas, MD, Peter Daley, MD, Robert Fowler, MD, David M. Maslove, MD, Brent W. Winston, MD, Todd C. Lee, MD, Karen C. Tran, MD, Matthew P. Cheng, MD, Donald C. Vinh, MD, John H. Boyd, MD, Keith R. Walley, MD, Joel Singer, PhD, John C. Marshall, MD, James A. Russell, MD, for the Community-Acquired Pneumonia: Toward InnoVAtive Treatment (CAPTIVATE) Investigators

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Association of Musculoskeletal Indexes With 1-Year Outcomes After ≥ 7 Days of Mechanical VentilationTake-Home Points by Hannah Wozniak, MD, Erminio Santangelo, Micheal McInnis, Laura Dragoi, Priscila Robles, Leslie M. Chu, Andrea Matte, Margaret S. Herridge, Margaret S. Herridge, Leslie M. Chu, Andrea Matte, George Tomlinson, Linda Chan, Claire Thomas, Jan O. Friedrich, Sangeeta Mehta, Francois Lamontagne, Melanie Levasseur, Niall D. Ferguson, Neill K.J. Adhikari, Jill C. Rudkowski, Hilary Meggison, Yoanna Skrobik, John Flannery, Mark Bayley, Jane Batt, Claudia dos Santos, Susan E. Abbey, Adrienne Tan, Vincent Lo, Sunita Mathur, Matteo Parotto, Denise Morris, Linda Flockhart, Eddy Fan, Christie M. Lee, M. Elizabeth Wilcox, Najib Ayas, Karen Choong, Robert Fowler, Damon C. Scales, Tasnim Sinuff, Brian H. Cuthbertson, Louise Rose, Priscila Robles, Stacey Burns, Marcelo Cypel, Lianne Singer, Cecelia Chaparro, Chung-Wai Chow, Shaf Keshavjee, Laurent Brochard, Paul Hebert, Arthur S. Slutsky, John C. Marshall, Deborah Cook, Jill I. Cameron, Margaret S. Herridge, Leslie M. Chu: Andrea Matte, George Tomlinson, Linda Chan, Claire Thomas, Jan O. Friedrich, Sangeeta Mehta, Francois Lamontagne, Melanie Levasseur, Niall D. Ferguson, Neill K.J. Adhikari, Jill C. Rudkowski, Hilary Meggison, Yoanna Skrobik, John Flannery, Mark Bayley, Jane Batt, Claudia dos Santos, Susan E. Abbey, Adrienne Tan, Vincent Lo, Sunita Mathur, Matteo Parotto, Denise Morris, Linda Flockhart, Eddy Fan, Christie M. Lee, M. Elizabeth Wilcox, Najib Ayas, Karen Choong, Robert Fowler, Damon C. Scales, Tasnim Sinuff, Brian H. Cuthbertson, Louise Rose, Priscila Robles, Stacey Burns, Marcelo Cypel, Lianne Singer, Cecelia Chaparro, Chung-Wai Chow, Shaf Keshavjee, Laurent Brochard, Paul Hebert, Arthur S. Slutsky, John C. Marshall, Deborah Cook, Jill I. Cameron

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Canadian Adaptive Platform Trial of Treatments for COVID in Community Settings (CanTreatCOVID): protocol for a randomised controlled adaptive platform trial of treatments for acute... by Catherine Hudon, Kris Aubrey-Bassler, Vivian R Ramsden, Machelle Wilchesky, Paul Little, Michelle Greiver, Rahim Moineddin, Ryan Zarychanski, Jean-Eric Tarride, Annie Leblanc, Peter Jüni, Dee Mangin, Robert Fowler, Srinivas Murthy, Jennifer Rayner, Alexander Singer, Yoav Keynan, Simone Dahrouge, Emily Gard Marshall, Rita McCracken, Sabrina T Wong, David J A Jenkins, Kerry McBrien, Nav Persaud, Anita Srivastava, Jennifer Isenor, Todd C Lee, Christopher C Butler, John C Marshall, Stephanie Garies, Valeria E Rac, Ross E G Upshur, Peter Selby, Marie-Thérèse Lussier, Sarvesh Logsetty, Andrew David Pinto, Melissa Andrew, Brianne Wood, Emily G McDonald, Amanda Condon, Aisha Lofters, Christine Leong, Lynora Saxinger, Rachel Walsh, Abhimanyu Sud, Sylvain Lother, Jean-Sébastien Paquette, David Barber, Brendan Barrett, Rae Spiwak, Sakina Walji, Ali Damji, Banafshe Hosseini, Bruno R. da Costa, Peter Daley, Noah Crampton, Jennifer Hulme, Rosemarie Lall, Laura Maclaren, Brianna Orava, Jay Jae Hee Park, Diana C. Sanchez-Ramirez, Haolun Shi, Deanna Telner, Barb Zelek, Jolanta Piszczek, Daniel Warshafsky

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Building an international precision medicine platform trial for the acute respiratory distress syndrome (ARDS): an expert consensus project report by Kiran Reddy, Neil Aggarwal, Narges Alipanah-Lechner, Djillali Annane, David B Antcliffe, Daphne Babalis, J Kenneth Baillie, Abigail Beane, Lieuwe DJ Bos, Aidan Burrell, Carolyn S Calfee, Kiki Cano-Gamez, Victoria R Cornelius, Mary Cross, Emma Davenport, Lorenzo del Sorbo, Laura Esserman, Eddy Fan, Vito Fanelli, Niall D Ferguson, D Clark Files, Christoph Fisser, Shigeki Fujitani, Ewan C Goligher, Anthony C Gordon, Giacomo Grasselli, Fergus Hamilton, Rashan Haniffa, Andrea Haren, Daniel JR Harvey, Leanne M Hays, Anna Heath, Nicholas Heming, Susanne Herold, Tim Hicks, Nao Ichihara, Vinod Jaiswal, Jun Kataoka, Julian C Knight, Patrick R Lawler, Kathleen Liu, John C Marshall, David M Maslove, Michael A Matthay, Daniel F McAuley, Nuala J Meyer, Jonathan A Millar, Holger Müller-Redetzky, Alistair Nichol, John Norrie, Marlies Ostermann, Andrew Owen, Cecilia M O’Kane, Dhruv Parekh, Rachel Phillips, Duncan Richards, Bram Rochwerg, Anthony J Rostron, Hiroki Saito, Romit J Samanta, Vittorio Scaravilli, Wesley Self, Manu Shankar-Hari, A John Simpson, Pratik Sinha, Marry R Smit, Jonathan Stewart, B Taylor Thompson, István Vadász, Ed Waddingham, Steve Webb, Graham Wheeler, D Martin Witzenrath, Mark M Wurfel, Thomas R Martin

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Identifying heterogeneity of treatment effect for antibiotic duration in bloodstream infection: an exploratory post-hoc analysis of the BALANCE randomised clinical trialResearch in... by Sean W.X. Ong, Ruxandra Pinto, Asgar Rishu, Steven Y.C. Tong, Robert J. Commons, John M. Conly, Gerald A. Evans, Michael Fralick, Christopher Kandel, Philippe R.S. Lagacé-Wiens, Todd C. Lee, Sylvain A. Lother, Derek R. MacFadden, John C. Marshall, Valérie Martel-Laferrière, Michael Mayette, Emily G. McDonald, John D. Neary, Josef Prazak, Edward Raby, Adrian Regli, Benjamin A. Rogers, Stephanie Smith, Linda R. Taggart, Han Ting Wang, Terence Wuerz, Dafna Yahav, Paul J. Young, Robert A. Fowler, Nick Daneman, Nick Daneman, Asgar Rishu, Ruxandra Pinto, Benjamin Rogers, Yahya Shehabi, Rachael Parke, Deborah J. Cook, Yaseen Arabi, John Muscedere, Steven Reynolds, Richard Hall, Dhiraj Bhatia Dwivedi, Colin McArthur, Shay McGuinness, Dafna Yahav, Bryan Coburn, Anna Geagea, Pavani Das, Phillip Shin, Michael Detsky, Andrew Morris, Michael Fralick, Jeff E. Powis, Christopher Kandel, Wendy Sligl, Sean M. Bagshaw, Nishma Singhal, Emilie Belley-Cote, Richard Whitlock, Kosar Khwaja, Susan Morpeth, Alex Kazemi, Tony Williams, Derek R. MacFadden, Lauralyn McIntyre, Jennifer L.Y. Tsang, Francois Lamontagne, Alex Carignan, John Marshall, Jan O. Friedrich, Robert Cirone, Mark Downing, Christopher Graham, Joshua Davis, Erick Duan, John Neary, Gerald Evans, Basem Alraddadi, Sameera Al Johani, Claudio Martin, Sameer Elsayed, Ian Ball, François Lauzier, Alexis F. Turgeon, Henry Thomas Stelfox, John Conly, Todd C. Lee, Emily G. McDonald, Richard Sullivan, Jennifer Grant, Ilya Kagan, Paul Young, Cassie Lawrence, Kevin O'Callaghan, Matthew Eustace, Keat Choong, Pierre Aslanian, Ulrike Buehner, Tom Havey, Alexandra Binnie, Josef Prazak, Brenda Reeve, Edward Litton, Sylvain Lother, Anand Kumar, Ryan Zarychanski, Tomer Hoffman, David L. Paterson, Peter Daley, Robert J. Commons, Emmanuel Charbonney, Jean-Francois Naud, Sally Roberts, Ravindranath Tiruvoipati, Sachin Gupta, Gordon Wood, Omar Shum, Spiros Miyakis, Peter Dodek, Clement Kwok, Linda R. Taggart, Stephanie Smith, Karen Doucette, Robert A. Fowler

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