High-throughput modular click chemistry synthesis of catechol derivatives as covalent inhibitors of SARS-CoV-2 3CL pro by Feng Wang, Tiancheng Ma, Donglan Liu, Yixin Cen, Shidong Deng, Lu Zhang, Guoqiang Lin, Dingding Gao, Jincun Zhao, Jiajia Dong, Ping Tian

Get full text

Rapid generation of HCoV-229E and HCoV-OC43 reporter viruses and replicons for antiviral research by Yuyuan Zhang, Jiannan Chen, Hui Feng, Lulu Yang, Liyuan Hu, Yang Gao, Ziqiao Wang, Fei Feng, Jincun Zhao, Ping Zhang, Rong Zhang

Get full text

Antibody dynamics for heterologous boosters with aerosolized Ad5-nCoV following inactivated COVID-19 vaccines by Canjie Chen, Tian Tang, Zhao Chen, Lan Chen, Jinling Cheng, Fang Li, Jing Sun, Jingxian Zhao, Yanqun Wang, Qihong Yan, Jincun Zhao, Airu Zhu

Get full text

Dominant and cross-reactive S1-specific memory B cell response induced by primary SARS-CoV-2 infection by Xiaomin Xing, Zhaoyong Zhang, Yingfen Wen, Wenjing Guo, Xulei Zhang, Yuyi Min, Kexin Zhong, Lu Zhang, Peilan Wei, Shengnan Zhang, Yuejun Pan, Yanqun Wang, Jincun Zhao, Yongjun Guan, Lei Yu

Get full text

Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection by Wenxu Jia, Rudragouda Channappanavar, Chao Zhang, Mingxi Li, Haixia Zhou, Shuyuan Zhang, Panpan Zhou, Jiuyang Xu, Sisi Shan, Xuanling Shi, Xinquan Wang, Jincun Zhao, Dongming Zhou, Stanley Perlman, Linqi Zhang

Get full text

HLA-Bw4 in association with KIR3DL1 favors natural killer cell-mediated protection against severe COVID-19 by Ruihua Wang, Ying Sun, Bo-Hua Kuang, Xiao Yan, Jinju Lei, Yu-Xin Lin, Jinxiu Tian, Yating Li, Xiaoduo Xie, Tao Chen, Hui Zhang, Yi-Xin Zeng, Jincun Zhao, Lin Feng

Get full text

Corrigendum to: Long-Term Protection from SARS-CoV-2 Variants in Mice by a Phase II Clinically Evaluated Original mRNA Vaccine Booster by Jun Liu, Jing Sun, Liping Luo, Yanhong Tang, Hu Guo, Yiyun He, Qi Liu, Xuya Yu, Yumei Huang, Siyuan Zhang, Airu Zhu, Jun Dai, Fan Zhang, Tao Huang, Jincun Zhao, Yucai Peng

Get full text

Long-Term Protection from SARS-CoV-2 Variants in Mice by a Phase II Clinically Evaluated Original mRNA Vaccine Booster by Jun Liu, Jing Sun, Liping Luo, Yanhong Tang, Hu Guo, Yiyun He, Qi Liu, Xuya Yu, Yumei Huang, Siyuan Zhang, Airu Zhu, Jun Dai, Fan Zhang, Tao Huang, Jincun Zhao, Yucai Peng

Get full text

Structure-guided bispecific antibody engineering confers broad protection against KP.3.1.1 and sarbecoviruses by Yunping Ma, Qianying Liu, Palizhati Rehati, Zhaoyong Zhang, Yingdan Wang, Zhimin Liu, Jiali Chen, Xuezhou Bai, Aihua Hao, Yanqun Wang, Yumei Wen, Zhenguo Chen, Lu Lu, Jincun Zhao, Fan Wu, Lei Sun, Jinghe Huang

Get full text

Anti-SARS-CoV-2 prodrug ATV006 has broad-spectrum antiviral activity against human and animal coronaviruses by Tiefeng Xu, Kun Li, Siyao Huang, Konstantin I. Ivanov, Sidi Yang, Yanxi Ji, Hanwei Zhang, Wenbin Wu, Ye He, Qiang Zeng, Feng Cong, Qifan Zhou, Yingjun Li, Jian Pan, Jincun Zhao, Chunmei Li, Xumu Zhang, Liu Cao, Deyin Guo

Get full text

An RBD-Fc mucosal vaccine provides variant-proof protection against SARS-CoV-2 in mice and hamsters by Yanjun Zhang, Yan Wu, Meng-Qian Zhang, Haiyue Rao, Zhaoyong Zhang, Xiangyue He, Yiwen Liang, Raoqing Guo, Yaochang Yuan, Jing Sun, Helen M. E. Duyvesteyn, Elizabeth E. Fry, David I. Stuart, Jingxian Zhao, XiaoYan Pan, Shu-Lin Liu, Jincun Zhao, Jiandong Huo

Get full text

Author Correction: An RBD-Fc mucosal vaccine provides variant-proof protection against SARS-CoV-2 in mice and hamsters by Yanjun Zhang, Yan Wu, Meng-Qian Zhang, Haiyue Rao, Zhaoyong Zhang, Xiangyue He, Yiwen Liang, Raoqing Guo, Yaochang Yuan, Jing Sun, Helen M. E. Duyvesteyn, Elizabeth E. Fry, David I. Stuart, Jingxian Zhao, XiaoYan Pan, Shu-Lin Liu, Jincun Zhao, Jiandong Huo

Get full text

Discovery of a subgenotype of human coronavirus NL63 associated with severe lower respiratory tract infection in China, 2018 by Yanqun Wang, Xin Li, Wenkuan Liu, Mian Gan, Lu Zhang, Jin Wang, Zhaoyong Zhang, Airu Zhu, Fang Li, Jing Sun, Guoxian Zhang, Zhen Zhuang, Jiaying Luo, Dehui Chen, Shuyan Qiu, Li Zhang, Duo Xu, Chris Ka Pun Mok, Fuchun Zhang, Jingxian Zhao, Rong Zhou, Jincun Zhao

Get full text

Deep immunoglobulin repertoire sequencing depicts a comprehensive atlas of spike-specific antibody lineages shared among COVID-19 convalescents by Qihong Yan, Yudi Zhang, Ruitian Hou, Wenjing Pan, Huan Liang, Xijie Gao, Weiqi Deng, Xiaohan Huang, Linbing Qu, Congli Tang, Ping He, Banghui Liu, Qian Wang, Xinwei Zhao, Zihan Lin, Zhaoming Chen, Pingchao Li, Jian Han, Xiaoli Xiong, Jincun Zhao, Song Li, Xuefeng Niu, Ling Chen

Get full text

In vivo determination of protective antibody thresholds for SARS-CoV-2 variants using mouse models by Peilan Wei, Ruoxi Cai, Lu Zhang, Jingjun Zhang, Zhaoyong Zhang, Airu Zhu, Hai Li, Zhen Zhuang, Lan Chen, Jiantao Chen, Yuting Zhang, Xinyi Xiong, Bin Qu, Jianfen Zhuo, Tian Tang, Yuanyuan Zhang, Lei Chen, Qier Zhong, Zhiwei Lin, Xindan Xing, Fang Li, Qingtao Hu, Jun Dai, Yongxia Shi, Jingxian Zhao, Jincun Zhao, Yanqun Wang

Get full text

Isolation of infectious SARS-CoV-2 from urine of a COVID-19 patient by Jing Sun, Airu Zhu, Heying Li, Kui Zheng, Zhen Zhuang, Zhao Chen, Yongxia Shi, Zhaoyong Zhang, Si-bei Chen, Xuesong Liu, Jun Dai, Xiaobo Li, Shuxiang Huang, Xiaofang Huang, Ling Luo, Liyan Wen, Jianfen Zhuo, Yuming Li, Yanqun Wang, Lu Zhang, Yanjun Zhang, Fang Li, Liqiang Feng, Xinwen Chen, Nanshan Zhong, Zifeng Yang, Jicheng Huang, Jincun Zhao, Yi-min Li

Get full text

A novel, covalent broad-spectrum inhibitor targeting human coronavirus Mpro by Jing Sun, Deheng Sun, Qi Yang, Dong Wang, Jingjing Peng, Hu Guo, Xiaoyu Ding, Zhao Chen, Bin Yuan, Yan A. Ivanenkov, Jinwei Yuan, Bogdan A. Zagribelnyy, Yiyun He, Jingyi Su, Ling Wang, Jielin Tang, Zhun Li, Rong Li, Taotao Li, Xiaoyu Hu, Xing Liang, Airu Zhu, Peilan Wei, Yaya Fan, Sang Liu, Jie Zheng, Xin Guan, Alex Aliper, Minglei Yang, Dmitry S. Bezrukov, Zhanhong Xie, Victor A. Terentiev, Guilin Peng, Daniil A. Polykovskiy, Alexander S. Malyshev, Maxim N. Malkov, Qingsong Zhu, Alán Aspuru-Guzik, Xiao Ding, Xin Cai, Man Zhang, Jingxian Zhao, Nanshan Zhong, Feng Ren, Xinwen Chen, Alex Zhavoronkov, Jincun Zhao

Get full text