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Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease by Benedikt Kretner, Johannes Trambauer, Akio Fukumori, Janina Mielke, Peer‐Hendrik Kuhn, Elisabeth Kremmer, Armin Giese, Stefan F Lichtenthaler, Christian Haass, Thomas Arzberger, Harald Steiner
Published 2016-03-01Get full text
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Charting γ-secretase substrates by explainable AI by Stephan Breimann, Frits Kamp, Gabriele Basset, Claudia Abou-Ajram, Gökhan Güner, Kanta Yanagida, Masayasu Okochi, Stephan A. Müller, Stefan F. Lichtenthaler, Dieter Langosch, Dmitrij Frishman, Harald Steiner
Published 2025-07-01Get full text
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γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds by Johannes Trambauer, Rosa Maria Rodriguez Sarmiento, Holly J. Garringer, Katja Salbaum, Liliana D. Pedro, Dennis Crusius, Ruben Vidal, Bernardino Ghetti, Dominik Paquet, Karlheinz Baumann, Lothar Lindemann, Harald Steiner
Published 2025-02-01Get full text
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Correction: γ‑Secretase modulator resistance of an aggressive Alzheimer‑causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds... by Johannes Trambauer, Rosa Maria Rodriguez Sarmiento, Holly J. Garringer, Katja Salbaum, Liliana D. Pedro, Dennis Crusius, Ruben Vidal, Bernardino Ghetti, Dominik Paquet, Karlheinz Baumann, Lothar Lindemann, Harald Steiner
Published 2025-04-01Get full text
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Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity by Gökhan Güner, Marlene Aßfalg, Kai Zhao, Tobias Dreyer, Shibojyoti Lahiri, Yun Lo, Bianca Ionela Slivinschi, Axel Imhof, Georg Jocher, Laura Strohm, Christian Behrends, Dieter Langosch, Holger Bronger, Christopher Nimsky, Jörg W Bartsch, Stanley R Riddell, Harald Steiner, Stefan F Lichtenthaler
Published 2022-09-01Get full text
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