Haakon IV
Haakon IV Haakonsson ( – 16 December 1263; ; ), sometimes called Haakon the Old in contrast to his namesake son, was King of Norway from 1217 to 1263. His reign lasted for 46 years, longer than any Norwegian king since Harald Fairhair. Haakon was born into the troubled civil war era in Norway, but his reign eventually managed to put an end to the internal conflicts. At the start of his reign, during his minority, Earl Skule Bårdsson served as regent. As a king of the Birkebeiner faction, Haakon defeated the uprising of the final Bagler royal pretender, Sigurd Ribbung, in 1227. He put a definitive end to the civil war era when he had Skule Bårdsson killed in 1240, a year after Skule had himself proclaimed king in opposition to Haakon. Haakon thereafter formally appointed his own eldest son, Haakon the Young, as his co-regent.Under Haakon's rule, medieval Norway is considered to have reached its zenith or golden age. His reputation and formidable naval fleet allowed him to maintain friendships with both the pope and the Holy Roman Emperor, despite their conflict. He was at different points offered the imperial crown by the pope, the High Kingship of Ireland by a delegation of Irish kings, and the command of the French crusader fleet by the French king. He amplified the influence of European culture in Norway by importing and translating contemporary European literature into Old Norse, and by constructing monumental European-style stone buildings. In conjunction with this he employed an active and aggressive foreign policy, and at the end of his rule added Iceland and the Norse Greenland community to his kingdom, leaving the Norwegian realm at its territorial height. Although he for the moment managed to secure Norwegian control of the islands off the northern and western shores of Scotland, plus the Isle of Man, he fell ill and died when wintering in Orkney following some military engagements with the expanding Kingdom of Scotland. He was succeeded by his second son, Magnus VI. Provided by Wikipedia
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Natural killer cell subpopulations in the peripheral blood of single ventricle/hypoplastic left heart syndrome patients via single-cell RNA sequencing by Hui-Qi Qu, Kushagra Goel, Kayleigh Ostberg, Diana J. Slater, Fengxiang Wang, James Snyder, Cuiping Hou, Garnet Eister, John J. Connolly, Michael March, Joseph T. Glessner, Joseph T. Glessner, Joseph T. Glessner, Charlly Kao, Hakon Hakonarson, Hakon Hakonarson, Hakon Hakonarson, Hakon Hakonarson, Hakon Hakonarson
Published 2025-08-01Get full text
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Role of genetic modifiers on pulmonary consequences of cancer therapy in children by Shoshana Leftin Dobkin, Xiao Chang, Frank Mentch, Hakon Hakonarson
Published 2025-05-01Get full text
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GDF15 is a heart‐derived hormone that regulates body growth by Ting Wang, Jian Liu, Caitlin McDonald, Katherine Lupino, Xiandun Zhai, Benjamin J Wilkins, Hakon Hakonarson, Liming Pei
Published 2017-06-01Get full text
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O57: Association of polygenic risk scores with disease prevalence in pediatrics: Insights into obesity, asthma, type 1 and type 2 diabetes by Margaret Harr, Priyanka Maripuri, Huiqi Qu, Haijun Qiu, Shannon Terek, Jasmine Purcell, Sam McCreary, Ciani Graham, John Connolly, Hakon Hakonarson
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The International Health Cohorts Consortium (IHCC) advances population health research and genomic discovery by John J. Connolly, Scott Sundseth, Grant M. Wood, Chisom Nwaneri, Geoffrey Ginsburg, Philip Awadalla, Michele Ramsay, Thomas Keane, Peter Goodhand, Adam S. Butterworth, Hakon Hakonarson
Published 2025-08-01Get full text
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Mendelian randomization analysis of plasma levels of CD209 and MICB proteins and the risk of varicose veins of lower extremities. by Alexandra S Shadrina, Elizaveta E Elgaeva, Ian B Stanaway, Gail P Jarvik, Bahram Namjou, Wei-Qi Wei, Joe Glessner, Hakon Hakonarson, Pradeep Suri, Yakov A Tsepilov
Published 2022-01-01Get full text
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DNA methylation differences stratified by normalized fetal/placental weight ratios suggest neurodevelopmental deficits in neonates with congenital heart disease. by Marin Jacobwitz, Michael Xie, Jamie Catalano, Ingo Helbig, J William Gaynor, Nancy Burnham, Rebecca L Linn, Juliana Gebb, Mark W Russell, Hakon Hakonarson, Barbara H Chaiyachati, Ana G Cristancho
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DNA methylation differences stratified by normalized fetal/placental weight ratios suggest neurodevelopmental deficits in neonates with congenital heart disease by Marin Jacobwitz, Michael Xie, Jamie Catalano, Ingo Helbig, J. William Gaynor, Nancy Burnham, Rebecca L. Linn, Juliana Gebb, Mark W. Russell, Hakon Hakonarson, Barbara H. Chaiyachati, Ana G. Cristancho
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Multi-trait genetic analysis of asthma and eosinophils uncovers pleiotropic loci in East Asians by Lili Zhi, Qiwen Zheng, Yue Jiang, Lu Yu, Linzehao Li, Yingchao Song, Bichen Peng, Chumeng Zhang, Hengxuan Jiang, Ren Li, Frank Mentch, Joseph Glessner, Peilin Jia, Hua Tang, Hakon Hakonarson, Xiao Chang
Published 2025-05-01Get full text
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Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma. by Lee D McDaniel, Karina L Conkrite, Xiao Chang, Mario Capasso, Zalman Vaksman, Derek A Oldridge, Anna Zachariou, Millicent Horn, Maura Diamond, Cuiping Hou, Achille Iolascon, Hakon Hakonarson, Nazneen Rahman, Marcella Devoto, Sharon J Diskin
Published 2017-05-01Get full text
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The knockout of Moesin leads to excess microglia-mediated synaptic pruning and impairs social novelty in a mouse model by Wanjing Lai, Junlin Chen, Hongyao Zhu, Yunbo Jiang, Yimei Niu, Qingpei Chen, Zhihua Luo, Yu Hu, Li Fang, Yaxuan Wang, Youqiang Song, Charlly Kao, Jubao Duan, Kwok-Fai So, Hakon Hakonarson, Li Zhang, Kai Wang, Lingling Shi
Published 2025-08-01Get full text
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Copy number variations in alternative splicing gene networks impact lifespan. by Joseph T Glessner, Albert Vernon Smith, Saarene Panossian, Cecilia E Kim, Nagahide Takahashi, Kelly A Thomas, Fengxiang Wang, Kallyn Seidler, Tamara B Harris, Lenore J Launer, Brendan Keating, John Connolly, Patrick M A Sleiman, Joseph D Buxbaum, Struan F A Grant, Vilmundur Gudnason, Hakon Hakonarson
Published 2013-01-01Get full text
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A framework for conducting GWAS using repeated measures data with an application to childhood BMI by Kimberley Burrows, Anni Heiskala, Jonathan P. Bradfield, Zhanna Balkhiyarova, Lijiao Ning, Mathilde Boissel, Yee-Ming Chan, Philippe Froguel, Amelie Bonnefond, Hakon Hakonarson, Alexessander Couto Alves, Deborah A. Lawlor, Marika Kaakinen, Marjo-Riitta Järvelin, Struan F. A. Grant, Kate Tilling, Inga Prokopenko, Sylvain Sebert, Mickaël Canouil, Nicole M. Warrington
Published 2024-11-01Get full text
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Novel EDGE encoding method enhances ability to identify genetic interactions. by Molly A Hall, John Wallace, Anastasia M Lucas, Yuki Bradford, Shefali S Verma, Bertram Müller-Myhsok, Kristin Passero, Jiayan Zhou, John McGuigan, Beibei Jiang, Sarah A Pendergrass, Yanfei Zhang, Peggy Peissig, Murray Brilliant, Patrick Sleiman, Hakon Hakonarson, John B Harley, Krzysztof Kiryluk, Kristel Van Steen, Jason H Moore, Marylyn D Ritchie
Published 2021-06-01Get full text
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Integration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis by Meritxell Oliva, Mrinal K. Sarkar, Michael E. March, Amir Hossein Saeidian, Frank D. Mentch, Chen-Lin Hsieh, Fanying Tang, Ranjitha Uppala, Matthew T. Patrick, Qinmengge Li, Rachael Bogle, J. Michelle Kahlenberg, Deborah Watson, Joseph T. Glessner, Leila Youssefian, Hassan Vahidnezhad, Lam C. Tsoi, Hakon Hakonarson, Johann E. Gudjonsson, Kathleen M. Smith, Bridget Riley-Gillis
Published 2025-04-01Get full text
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Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy. by Ulrike Esslinger, Sophie Garnier, Agathe Korniat, Carole Proust, Georgios Kararigas, Martina Müller-Nurasyid, Jean-Philippe Empana, Michael P Morley, Claire Perret, Klaus Stark, Alexander G Bick, Sanjay K Prasad, Jennifer Kriebel, Jin Li, Laurence Tiret, Konstantin Strauch, Declan P O'Regan, Kenneth B Marguiles, Jonathan G Seidman, Pierre Boutouyrie, Patrick Lacolley, Xavier Jouven, Christian Hengstenberg, Michel Komajda, Hakon Hakonarson, Richard Isnard, Eloisa Arbustini, Harald Grallert, Stuart A Cook, Christine E Seidman, Vera Regitz-Zagrosek, Thomas P Cappola, Philippe Charron, François Cambien, Eric Villard
Published 2017-01-01Get full text
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