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Mechanistic Insights into the Adenosine A1 Receptor’s Positive Allosteric Modulation for Non-Opioid Analgesics by Tal Weizmann, Abigail Pearce, Peter Griffin, Achille Schild, Maren Flaßhoff, Philipp Grossenbacher, Martin Lochner, Christopher A. Reynolds, Graham Ladds, Giuseppe Deganutti
Published 2024-12-01Get full text
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Agonist efficacy at the β2AR is driven by the faster association rate of the Gs protein by Clare R. Harwood, Clare R. Harwood, David A. Sykes, David A. Sykes, David A. Sykes, Theo Redfern-Nichols, Owen Underwood, Colin Nicholson, Colin Nicholson, Armin N. Khoshgrudi, Armin N. Khoshgrudi, Eline J. Koers, Eline J. Koers, Graham Ladds, Graham Ladds, Stephen J. Briddon, Stephen J. Briddon, Dmitry B. Veprintsev, Dmitry B. Veprintsev, Dmitry B. Veprintsev
Published 2025-03-01Get full text
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New heterocyclic A1/A3 adenosine receptor ligands through molecular simplification strategies by Letizia Crocetti, Abigail Pearce, Venkat S. Vege, Qi Xu, Jing Xu, Hannes Buthmann, Maria Paola Giovannoni, Gabriella Guerrini, Francesca Catarzi, Silvia Selleri, Xianglin Huang, Aneesh Chandran, Graham Ladds, Agostino Cilibrizzi
Published 2025-04-01Get full text
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