Editorial: Immunomodulatory molecules of natural origin: innovative strategies for combatting cancer by Lekshmi R. Nath, Gautam Sethi, Vijayasteltar B. Liju

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Advances in cancer immunotherapy: historical perspectives, current developments, and future directions by Meiyin Zhang, Chaojun Liu, Jing Tu, Min Tang, Milad Ashrafizadeh, Noushin Nabavi, Gautam Sethi, Peiqing Zhao, Shijian Liu

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Targeting RTKs/nRTKs as promising therapeutic strategies for the treatment of triple-negative breast cancer: evidence from clinical trials by Kasshish Mehta, Mangala Hegde, Sosmitha Girisa, Ravichandran Vishwa, Mohammed S. Alqahtani, Mohamed Abbas, Mehdi Shakibaei, Gautam Sethi, Ajaikumar B. Kunnumakkara

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Gut microbiota and their influence in brain cancer milieu by Bandari BharathwajChetty, Aviral Kumar, Pranav Deevi, Mohamed Abbas, Athba Alqahtani, Liping Liang, Gautam Sethi, Le Liu, Ajaikumar B Kunnumakkara

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The solute carrier family 11 transporters: a bridge between iron homeostasis and tumor biology by Ruchira Banerjee, Bintee Bintee, Mukesh Kumar Manickasamy, Shristy Jha, Mohammed S. Alqahtani, Mohamed Abbas, Arul Goel, Gautam Sethi, Zhaowu Ma, Ajaikumar B. Kunnumakkara

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A novel BCAT1 inhibitor bufalin sensitizes pancreatic cancer cells to chemotherapy by Wei Zhang, Yibao Fan, Milad Ashrafizadeh, Dan Shi, Gautam Sethi, Yavuz Nuri Ertas, A.M. Abd El-Aty, Xianbin Zhang, Si Chen, Peng Gong

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Next-generation immunotherapeutic approaches for blood cancers: Exploring the efficacy of CAR-T and cancer vaccines by Kiavash Hushmandi, Abbas Ali Imani Fooladi, Russel J. Reiter, Najma Farahani, Liping Liang, Amir Reza Aref, Noushin Nabavi, Mina Alimohammadi, Le Liu, Gautam Sethi

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In vivo CRISPR screening identifies POU3F3 as a novel regulator of ferroptosis resistance in hepatocellular carcinoma via retinoic acid signaling by Yu Tian, Xin Bao, Shan Lei, Youcai Huang, Xiaoling Wang, Yanyang Tu, Qinglian He, Feixiang Zhang, Haicheng Xu, Milad Ashrafizadeh, Gautam Sethi, Furong Wang, Zhirui Zeng

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SNRPB/CCNB1 axis promotes hepatocellular carcinoma progression and cisplatin resistance through enhancing lipid metabolism reprogramming by Xin Jin, Xigan He, Runze Huang, Qinyu Liu, Lei Wang, Xuanci Bai, Yibin Wu, Yixiu Wang, Ziting Jiang, Yi Shi, Gautam Sethi, Lu Wang, Weiping Zhu

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Histone lysine crotonylation accelerates ACSL4-mediated ferroptosis of keratinocytes via modulating autophagy in diabetic wound healing by Fengjuan Li, Haowen Ye, Lanlan Li, Qingling Chen, Xianwu Lan, Liangxiu Wu, Bin Li, Lishan Li, Chuxian Guo, Milad Ashrafizadeh, Gautam Sethi, Jun Guo, Liangyan Wu

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Comprehensive review of opportunities and challenges of ethnomedicinal plants for managing type 2 diabetes by Valizadeh Lakeh Mahmoud, Ramtin Shayesteh, Trisha Krishni Foong Yun Loh, Sook Wah Chan, Gautam Sethi, Kevin Burgess, Sau Har Lee, Won Fen Wong, Chung Yeng Looi

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A new 1,2,3-triazole-indirubin hybrid suppresses tumor growth and pulmonary metastasis by mitigating the HGF/c-MET axis in hepatocellular carcinoma by Shalini V. Gowda, Na Young Kim, Kachigere B. Harsha, Darshini Gowda, Rajaghatta N. Suresh, Amudha Deivasigamani, Chakrabhavi Dhananjaya Mohan, Kam Man Hui, Gautam Sethi, Kwang Seok Ahn, Kanchugarakoppal S. Rangappa

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Biomembrane‐coated nanosystems as next‐generation delivery systems for the treatment of gastrointestinal cancers by Joana Lopes, Daniela Lopes, Mahzad Motallebi, Mengguang Ye, Yuxiang Xue, Amélia C. F. Vieira, Sachin Kumar Singh, Kamal Dua, Francisco Veiga, Gautam Sethi, Ana Cláudia Paiva‐Santos, Pooyan Makvandi

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A novel drug prejudice scaffold-imidazopyridine-conjugate can promote cell death in a colorectal cancer model by binding to β-catenin and suppressing the Wnt signaling pathway by Min Hee Yang, Basappa Basappa, Suresha N. Deveshegowda, Akshay Ravish, Arunkumar Mohan, Omantheswara Nagaraja, Mahendra Madegowda, Kanchugarakoppal S. Rangappa, Amudha Deivasigamani, Vijay Pandey, Peter E. Lobie, Kam Man Hui, Gautam Sethi, Kwang Seok Ahn

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ARID1A is a coactivator of STAT5 that contributes to CD8+ T cell dysfunction and anti-PD-1 resistance in gastric cancer by Fangqi Ma, Mingming Ren, Zhongqiu Li, Yujing Tang, Xiaoyu Sun, Yi Wang, Nida Cao, Xiaohong Zhu, Yan Xu, Rui Wang, Yumiao Shen, Ruohan Zhao, Zhaoyan Li, Milad Ashrafizadeh, Gautam Sethi, Furong Wang, Aiguang Zhao

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Exosome autoantibody biomarkers for detection of lung cancer by Win Lwin Thuya, Janique Michelle Peyper, Tan Ti Myen, Nur Diana Anuar, Arif Anwar, Ranga Gudimella, Nurul Huda Rutt, Nurul Shielawati Mohamed Rosli, Noorul Hidayah Badri, Teh Norleila Abdul Rahman, Raja Nurashirin, Gautam Sethi, John Kit Chung Tam, Andrea Li-Ann Wong, Ross Soo, Jonathan M. Blackburn, Lingzhi Wang, Boon Cher Goh

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Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition by Antonino Glaviano, Hannah Si-Hui Lau, Lukas M. Carter, E. Hui Clarissa Lee, Hiu Yan Lam, Elena Okina, Donavan Jia Jie Tan, Wency Tan, Hui Li Ang, Daniela Carbone, Michelle Yi-Hui Yee, Muthu K. Shanmugam, Xiao Zi Huang, Gautam Sethi, Tuan Zea Tan, Lina H. K. Lim, Ruby Yun-Ju Huang, Hendrik Ungefroren, Elisa Giovannetti, Dean G. Tang, Tullia C. Bruno, Peng Luo, Mads Hald Andersen, Bin-Zhi Qian, Jun Ishihara, Derek C. Radisky, Salem Elias, Saurabh Yadav, Minah Kim, Caroline Robert, Patrizia Diana, Kurt A. Schalper, Tao Shi, Taha Merghoub, Simone Krebs, Anjali P. Kusumbe, Matthew S. Davids, Jennifer R. Brown, Alan Prem Kumar

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