Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents. by Carolina Lahmann, Holger B Kramer, Frances M Ashcroft

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FTO is expressed in neurones throughout the brain and its expression is unaltered by fasting. by James S McTaggart, Sheena Lee, Michaela Iberl, Chris Church, Roger D Cox, Frances M Ashcroft

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Gain-of-function mutations in the K(ATP) channel (KCNJ11) impair coordinated hand-eye tracking. by James S McTaggart, Ned Jenkinson, John-Stuart Brittain, Siri A W Greeley, Andrew T Hattersley, Frances M Ashcroft

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Changes in gene expression associated with FTO overexpression in mice. by Myrte Merkestein, James S McTaggart, Sheena Lee, Holger B Kramer, Fiona McMurray, Mathilde Lafond, Lily Boutens, Roger Cox, Frances M Ashcroft

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Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells by Elizabeth Haythorne, Matthew Lloyd, John Walsby-Tickle, Andrei I. Tarasov, Jonas Sandbrink, Idoia Portillo, Raul Terron Exposito, Gregor Sachse, Malgorzata Cyranka, Maria Rohm, Patrik Rorsman, James McCullagh, Frances M. Ashcroft

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Pharmacological inhibition of FTO. by Fiona McMurray, Marina Demetriades, WeiShen Aik, Myrte Merkestein, Holger Kramer, Daniel S Andrew, Cheryl L Scudamore, Tertius A Hough, Sara Wells, Frances M Ashcroft, Michael A McDonough, Christopher J Schofield, Roger D Cox

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PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. by Gema Medina-Gomez, Sarah L Gray, Laxman Yetukuri, Kenju Shimomura, Sam Virtue, Mark Campbell, R Keira Curtis, Mercedes Jimenez-Linan, Margaret Blount, Giles S H Yeo, Miguel Lopez, Tuulikki Seppänen-Laakso, Frances M Ashcroft, Matej Oresic, Antonio Vidal-Puig

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Adult onset global loss of the fto gene alters body composition and metabolism in the mouse. by Fiona McMurray, Chris D Church, Rachel Larder, George Nicholson, Sara Wells, Lydia Teboul, Y C Loraine Tung, Debra Rimmington, Fatima Bosch, Veronica Jimenez, Giles S H Yeo, Stephen O'Rahilly, Frances M Ashcroft, Anthony P Coll, Roger D Cox

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Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5. by Nellie Y Loh, Liz Bentley, Henrik Dimke, Sjoerd Verkaart, Paolo Tammaro, Caroline M Gorvin, Michael J Stechman, Bushra N Ahmad, Fadil M Hannan, Sian E Piret, Holly Evans, Ilaria Bellantuono, Tertius A Hough, William D Fraser, Joost G J Hoenderop, Frances M Ashcroft, Steve D M Brown, René J M Bindels, Roger D Cox, Rajesh V Thakker

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