Superoxide dismutase 1 and tgSOD1 mouse spinal cord seed fibrils, suggesting a propagative cell death mechanism in amyotrophic lateral sclerosis. by Ruth Chia, M Howard Tattum, Samantha Jones, John Collinge, Elizabeth M C Fisher, Graham S Jackson

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Mouse Models of Aneuploidy by Olivia Sheppard, Frances K. Wiseman, Aarti Ruparelia, Victor L. J. Tybulewicz, Elizabeth M. C. Fisher

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Mouse cytoplasmic dynein intermediate chains: identification of new isoforms, alternative splicing and tissue distribution of transcripts. by Anna Kuta, Wenhan Deng, Ali Morsi El-Kadi, Gareth T Banks, Majid Hafezparast, K Kevin Pfister, Elizabeth M C Fisher

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The effects of Cstb duplication on APP/amyloid-β pathology and cathepsin B activity in a mouse model. by Yixing Wu, Heather T Whittaker, Suzanna Noy, Karen Cleverley, Veronique Brault, Yann Herault, Elizabeth M C Fisher, Frances K Wiseman

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Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1(G93A) motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice. by Gareth T Banks, Virginie Bros-Facer, Hazel P Williams, Ruth Chia, Francesca Achilli, J Barney Bryson, Linda Greensmith, Elizabeth M C Fisher

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Genetic analysis of the cytoplasmic dynein subunit families. by K Kevin Pfister, Paresh R Shah, Holger Hummerich, Andreas Russ, James Cotton, Azlina Ahmad Annuar, Stephen M King, Elizabeth M C Fisher

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Alterations to dendritic spine morphology, but not dendrite patterning, of cortical projection neurons in Tc1 and Ts1Rhr mouse models of Down syndrome. by Matilda A Haas, Donald Bell, Amy Slender, Eva Lana-Elola, Sheona Watson-Scales, Elizabeth M C Fisher, Victor L J Tybulewicz, François Guillemot

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Modification of superoxide dismutase 1 (SOD1) properties by a GFP tag--implications for research into amyotrophic lateral sclerosis (ALS). by James C Stevens, Ruth Chia, William T Hendriks, Virginie Bros-Facer, Jan van Minnen, Joanne E Martin, Graham S Jackson, Linda Greensmith, Giampietro Schiavo, Elizabeth M C Fisher

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A nonsense mutation in mouse Tardbp affects TDP43 alternative splicing activity and causes limb-clasping and body tone defects. by Thomas Ricketts, Philip McGoldrick, Pietro Fratta, Pietro Fratta, Hugo M de Oliveira, Rosie Kent, Vinaya Phatak, Sebastian Brandner, Gonzalo Blanco, Linda Greensmith, Abraham Acevedo-Arozena, Elizabeth M C Fisher

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ENU mutagenesis reveals a novel phenotype of reduced limb strength in mice lacking fibrillin 2. by Gaynor Miller, Monica Neilan, Ruth Chia, Nabeia Gheryani, Natalie Holt, Annabelle Charbit, Sara Wells, Valter Tucci, Zuzanne Lalanne, Paul Denny, Elizabeth M C Fisher, Michael Cheeseman, Graham N Askew, T Neil Dear

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Fully-Automated μMRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome. by Nick M Powell, Marc Modat, M Jorge Cardoso, Da Ma, Holly E Holmes, Yichao Yu, James O'Callaghan, Jon O Cleary, Ben Sinclair, Frances K Wiseman, Victor L J Tybulewicz, Elizabeth M C Fisher, Mark F Lythgoe, Sébastien Ourselin

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Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome. by Susan M Gribble, Frances K Wiseman, Stephen Clayton, Elena Prigmore, Elizabeth Langley, Fengtang Yang, Sean Maguire, Beiyuan Fu, Diana Rajan, Olivia Sheppard, Carol Scott, Heidi Hauser, Philip J Stephens, Lucy A Stebbings, Bee Ling Ng, Tomas Fitzgerald, Michael A Quail, Ruby Banerjee, Kai Rothkamm, Victor L J Tybulewicz, Elizabeth M C Fisher, Nigel P Carter

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Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans. by Joyce van de Leemput, Jayanth Chandran, Melanie A Knight, Lynne A Holtzclaw, Sonja Scholz, Mark R Cookson, Henry Houlden, Katrina Gwinn-Hardy, Hon-Chung Fung, Xian Lin, Dena Hernandez, Javier Simon-Sanchez, Nick W Wood, Paola Giunti, Ian Rafferty, John Hardy, Elsdon Storey, R J McKinlay Gardner, Susan M Forrest, Elizabeth M C Fisher, James T Russell, Huaibin Cai, Andrew B Singleton

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A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. by Heshan Peiris, Michael D Duffield, Joao Fadista, Claire F Jessup, Vinder Kashmir, Amanda J Genders, Sean L McGee, Alyce M Martin, Madiha Saiedi, Nicholas Morton, Roderick Carter, Michael A Cousin, Alexandros C Kokotos, Nikolay Oskolkov, Petr Volkov, Tertius A Hough, Elizabeth M C Fisher, Victor L J Tybulewicz, Jorge Busciglio, Pinar E Coskun, Ann Becker, Pavel V Belichenko, William C Mobley, Michael T Ryan, Jeng Yie Chan, D Ross Laybutt, P Toby Coates, Sijun Yang, Charlotte Ling, Leif Groop, Melanie A Pritchard, Damien J Keating

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A genome-wide investigation of SNPs and CNVs in schizophrenia. by Anna C Need, Dongliang Ge, Michael E Weale, Jessica Maia, Sheng Feng, Erin L Heinzen, Kevin V Shianna, Woohyun Yoon, Dalia Kasperaviciūte, Massimo Gennarelli, Warren J Strittmatter, Cristian Bonvicini, Giuseppe Rossi, Karu Jayathilake, Philip A Cola, Joseph P McEvoy, Richard S E Keefe, Elizabeth M C Fisher, Pamela L St Jean, Ina Giegling, Annette M Hartmann, Hans-Jürgen Möller, Andreas Ruppert, Gillian Fraser, Caroline Crombie, Lefkos T Middleton, David St Clair, Allen D Roses, Pierandrea Muglia, Clyde Francks, Dan Rujescu, Herbert Y Meltzer, David B Goldstein

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