Identification of factors directly linked to incident chronic obstructive pulmonary disease: A causal graph modeling study. by Robert W Gregg, Chad M Karoleski, Edwin K Silverman, Frank C Sciurba, Dawn L DeMeo, Panayiotis V Benos

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B-cell immune repertoire sequencing in tobacco cigarette smoking, vaping, and chronic obstructive pulmonary disease in the COPDGene cohort by Matthew Moll, Matthew Moll, Matthew Moll, Matthew Moll, Zhonghui Xu, Adel Boueiz, Adel Boueiz, Adel Boueiz, Min Hyung Ryu, Min Hyung Ryu, Edwin K. Silverman, Edwin K. Silverman, Edwin K. Silverman, Michael H. Cho, Michael H. Cho, Michael H. Cho, Craig P. Hersh, Craig P. Hersh, Craig P. Hersh, Maor Sauler, Francesca Polverino, Gregory L. Kinney, Jeffrey L. Curtis, Jeffrey L. Curtis, Laura E. Crotty-Alexander, Laura E. Crotty-Alexander, Christopher Vollmers, Peter J. Castaldi, Peter J. Castaldi, Peter J. Castaldi

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Assessing inflammatory protein biomarkers in COPD subjects with and without alpha-1 antitrypsin deficiency by Matthew Moll, Brian D. Hobbs, Katherine A. Pratte, Chengyue Zhang, Auyon J. Ghosh, Russell P. Bowler, David A. Lomas, Edwin K. Silverman, Dawn L. DeMeo

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A genome-wide association study of pulmonary function measures in the Framingham Heart Study. by Jemma B Wilk, Ting-Hsu Chen, Daniel J Gottlieb, Robert E Walter, Michael W Nagle, Brian J Brandler, Richard H Myers, Ingrid B Borecki, Edwin K Silverman, Scott T Weiss, George T O'Connor

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Relative contributions of family history and a polygenic risk score on COPD and related outcomes: COPDGene and ECLIPSE studies by Matthew Moll, Sharon M. Lutz, Auyon J. Ghosh, Phuwanat Sakornsakolpat, Craig P. Hersh, Terri H. Beaty, Frank Dudbridge, Martin D. Tobin, Murray A. Mittleman, Edwin K. Silverman, Brian D. Hobbs, Michael H. Cho

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A robust and adaptive framework for interaction testing in quantitative traits between multiple genetic loci and exposure variables. by Julian Hecker, Dmitry Prokopenko, Matthew Moll, Sanghun Lee, Wonji Kim, Dandi Qiao, Kirsten Voorhies, Woori Kim, Stijn Vansteelandt, Brian D Hobbs, Michael H Cho, Edwin K Silverman, Sharon M Lutz, Dawn L DeMeo, Scott T Weiss, Christoph Lange

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Identifying chronic obstructive pulmonary disease subtypes using multi-trait geneticsResearch in context by Andrey Ziyatdinov, Brian D. Hobbs, Samir Kanaan-Izquierdo, Matthew Moll, Phuwanat Sakornsakolpat, Nick Shrine, Jing Chen, Kijoung Song, Russell P. Bowler, Peter J. Castaldi, Martin D. Tobin, Peter Kraft, Edwin K. Silverman, Hanna Julienne, Michael H. Cho, Hugues Aschard

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Alternative poly-adenylation modulates α1-antitrypsin expression in chronic obstructive pulmonary disease. by Lela Lackey, Aaztli Coria, Auyon J Ghosh, Phil Grayeski, Abigail Hatfield, Vijay Shankar, John Platig, Zhonghui Xu, Silvia B V Ramos, Edwin K Silverman, Victor E Ortega, Michael H Cho, Craig P Hersh, Brian D Hobbs, Peter Castaldi, Alain Laederach

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A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. by Sreekumar G Pillai, Dongliang Ge, Guohua Zhu, Xiangyang Kong, Kevin V Shianna, Anna C Need, Sheng Feng, Craig P Hersh, Per Bakke, Amund Gulsvik, Andreas Ruppert, Karin C Lødrup Carlsen, Allen Roses, Wayne Anderson, Stephen I Rennard, David A Lomas, Edwin K Silverman, David B Goldstein, ICGN Investigators

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Genetics of sputum gene expression in chronic obstructive pulmonary disease. by Weiliang Qiu, Michael H Cho, John H Riley, Wayne H Anderson, Dave Singh, Per Bakke, Amund Gulsvik, Augusto A Litonjua, David A Lomas, James D Crapo, Terri H Beaty, Bartolome R Celli, Stephen Rennard, Ruth Tal-Singer, Steven M Fox, Edwin K Silverman, Craig P Hersh, ECLIPSE Investigators

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A simplified score to quantify comorbidity in COPD. by Nirupama Putcha, Milo A Puhan, M Bradley Drummond, MeiLan K Han, Elizabeth A Regan, Nicola A Hanania, Carlos H Martinez, Marilyn Foreman, Surya P Bhatt, Barry Make, Joe Ramsdell, Dawn L DeMeo, R Graham Barr, Stephen I Rennard, Fernando Martinez, Edwin K Silverman, James Crapo, Robert A Wise, Nadia N Hansel

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Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. by Alvar Agustí, Lisa D Edwards, Stephen I Rennard, William MacNee, Ruth Tal-Singer, Bruce E Miller, Jørgen Vestbo, David A Lomas, Peter M A Calverley, Emiel Wouters, Courtney Crim, Julie C Yates, Edwin K Silverman, Harvey O Coxson, Per Bakke, Ruth J Mayer, Bartolome Celli, Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators

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Genetic regulators of sputum mucin concentration and their associations with COPD phenotypes. by Eric Van Buren, Giorgia Radicioni, Sarah Lester, Wanda K O'Neal, Hong Dang, Silva Kasela, Suresh Garudadri, Jeffrey L Curtis, MeiLan K Han, Jerry A Krishnan, Emily S Wan, Edwin K Silverman, Annette Hastie, Victor E Ortega, Tuuli Lappalainen, Martijn C Nawijn, Maarten van den Berge, Stephanie A Christenson, Yun Li, Michael H Cho, Mehmet Kesimer, Samir N P Kelada

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Proteomic discovery analysis of quantitatively assessed emphysema in the general population. The MESA Lung Study by Daniel E. Guzman, Lisa Ruvuna, Claire J. Guo, Yifei Sun, Katherine A. Pratte, Ani W. Manichaikul, John S. Kim, Wendy S. Post, Alain G. Bertoni, Norrina B. Allen, Karol E. Watson, James S. Pankow, Eric A. Hoffman, Ruth F. Dubin, Rajat Deo, Igor Z. Barjaktarevic, Eugene R. Bleecker, Christopher B. Cooper, Victor E. Ortega, Annette T. Hastie, Robert Paine, James Michael Wells, Jeffrey L. Curtis, Edwin K. Silverman, Prescott G. Woodruff, Christine Kim Garcia, Jerome I. Rotter, Russell P. Bowler, Peter Ganz, R. Graham Barr

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The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. by Helen N Lyon, Valur Emilsson, Anke Hinney, Iris M Heid, Jessica Lasky-Su, Xiaofeng Zhu, Gudmar Thorleifsson, Steinunn Gunnarsdottir, G Bragi Walters, Unnur Thorsteinsdottir, Augustine Kong, Jeffrey Gulcher, Thuy Trang Nguyen, André Scherag, Arne Pfeufer, Thomas Meitinger, Günter Brönner, Winfried Rief, Manuel E Soto-Quiros, Lydiana Avila, Barbara Klanderman, Benjamin A Raby, Edwin K Silverman, Scott T Weiss, Nan Laird, Xiao Ding, Leif Groop, Tiinamaija Tuomi, Bo Isomaa, Kristina Bengtsson, Johannah L Butler, Richard S Cooper, Caroline S Fox, Christopher J O'Donnell, Caren Vollmert, Juan C Celedón, H Erich Wichmann, Johannes Hebebrand, Kari Stefansson, Christoph Lange, Joel N Hirschhorn

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Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD. by Wei Sun, Katerina Kechris, Sean Jacobson, M Bradley Drummond, Gregory A Hawkins, Jenny Yang, Ting-Huei Chen, Pedro Miguel Quibrera, Wayne Anderson, R Graham Barr, Patricia V Basta, Eugene R Bleecker, Terri Beaty, Richard Casaburi, Peter Castaldi, Michael H Cho, Alejandro Comellas, James D Crapo, Gerard Criner, Dawn Demeo, Stephanie A Christenson, David J Couper, Jeffrey L Curtis, Claire M Doerschuk, Christine M Freeman, Natalia A Gouskova, MeiLan K Han, Nicola A Hanania, Nadia N Hansel, Craig P Hersh, Eric A Hoffman, Robert J Kaner, Richard E Kanner, Eric C Kleerup, Sharon Lutz, Fernando J Martinez, Deborah A Meyers, Stephen P Peters, Elizabeth A Regan, Stephen I Rennard, Mary Beth Scholand, Edwin K Silverman, Prescott G Woodruff, Wanda K O'Neal, Russell P Bowler, SPIROMICS Research Group, COPDGene Investigators

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Susceptibility to chronic mucus hypersecretion, a genome wide association study. by Akkelies E Dijkstra, Joanna Smolonska, Maarten van den Berge, Ciska Wijmenga, Pieter Zanen, Marjan A Luinge, Mathieu Platteel, Jan-Willem Lammers, Magnus Dahlback, Kerrie Tosh, Pieter S Hiemstra, Peter J Sterk, Avi Spira, Jorgen Vestbo, Borge G Nordestgaard, Marianne Benn, Sune F Nielsen, Morten Dahl, W Monique Verschuren, H Susan J Picavet, Henriette A Smit, Michael Owsijewitsch, Hans U Kauczor, Harry J de Koning, Eva Nizankowska-Mogilnicka, Filip Mejza, Pawel Nastalek, Cleo C van Diemen, Michael H Cho, Edwin K Silverman, James D Crapo, Terri H Beaty, David A Lomas, Per Bakke, Amund Gulsvik, Yohan Bossé, Ma'en Obeidat, Daan W Loth, Lies Lahousse, Fernando Rivadeneira, Andre G Uitterlinden, Andre Hofman, Bruno H Stricker, Guy G Brusselle, Cornelia M van Duijn, Uilke Brouwer, Gerard H Koppelman, Judith M Vonk, Martijn C Nawijn, Harry J M Groen, Wim Timens, H Marike Boezen, Dirkje S Postma, LifeLines Cohort study

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