Protocol for the functional evaluation of genetic variants using saturation genome editing by Sofia Obolenski, Rebeca Olvera-León, Dijue Sun, David J. Adams, Andrew J. Waters

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No unexpected CRISPR-Cas9 off-target activity revealed by trio sequencing of gene-edited mice. by Vivek Iyer, Katharina Boroviak, Mark Thomas, Brendan Doe, Laura Riva, Edward Ryder, David J Adams

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Simulating CD8 T cell exhaustion: A comprehensive approach by Andrea J. Manrique-Rincón, Ben Foster, Stuart Horswell, David A. Goulding, David J. Adams, Anneliese O. Speak

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Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Ce... by Judit Espana-Agusti, Xiangang Zou, Kim Wong, Beiyuan Fu, Fengtang Yang, David A Tuveson, David J Adams, Athena Matakidou

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Impact of temporal variation on design and analysis of mouse knockout phenotyping studies. by Natasha A Karp, Anneliese O Speak, Jacqueline K White, David J Adams, Martin Hrabé de Angelis, Yann Hérault, Richard F Mott

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Contributions of protein-coding and regulatory change to adaptive molecular evolution in murid rodents. by Daniel L Halligan, Athanasios Kousathanas, Rob W Ness, Bettina Harr, Lél Eöry, Thomas M Keane, David J Adams, Peter D Keightley

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POT1 genetic testing in melanoma-prone families in Sweden: germline variant prevalence and tumor spectrum in identified carriers by Konstantinos Papadakis, Francesca Portelli, Karina Schultz, Hedvig Olsson Sterky, Ismini Vassilaki, Jan Lapins, Michael R. Sargen, Sofia Obolenski, David J. Adams, Muyi Yang, Veronica Höiom, Hildur Helgadottir

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Mcph1-deficient mice reveal a role for MCPH1 in otitis media. by Jing Chen, Neil Ingham, Simon Clare, Claire Raisen, Valerie E Vancollie, Ozama Ismail, Rebecca E McIntyre, Stephen H Tsang, Vinit B Mahajan, Gordon Dougan, David J Adams, Jacqueline K White, Karen P Steel

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CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression. by Michael P Schnetz, Lusy Handoko, Batool Akhtar-Zaidi, Cynthia F Bartels, C Filipe Pereira, Amanda G Fisher, David J Adams, Paul Flicek, Gregory E Crawford, Thomas Laframboise, Paul Tesar, Chia-Lin Wei, Peter C Scacheri

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Spider venom peptides with unique fold selectively block Shaker-type potassium channels by Alexey I. Kuzmenkov, Valentina A. Iunusova, Vladislav A. Lushpa, Yakov A. Deyev, Vladislav V. Babenko, Daniil V. Osipov, Antonina A. Berkut, Jan Tytgat, Eduard V. Bocharov, David J. Adams, Rocio K. Finol-Urdaneta, Alexander A. Vassilevski

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Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis. by Camille A Huser, Kathryn L Gilroy, Jeroen de Ridder, Anna Kilbey, Gillian Borland, Nancy Mackay, Alma Jenkins, Margaret Bell, Pawel Herzyk, Louise van der Weyden, David J Adams, Alistair G Rust, Ewan Cameron, James C Neil

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Commercially available outbred mice for genome-wide association studies. by Binnaz Yalcin, Jérôme Nicod, Amarjit Bhomra, Stuart Davidson, James Cleak, Laurent Farinelli, Magne Østerås, Adam Whitley, Wei Yuan, Xiangchao Gan, Martin Goodson, Paul Klenerman, Ansu Satpathy, Diane Mathis, Christophe Benoist, David J Adams, Richard Mott, Jonathan Flint

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A dominantly acting murine allele of Mcm4 causes chromosomal abnormalities and promotes tumorigenesis. by Bruce N Bagley, Thomas M Keane, Vilena I Maklakova, Jonathon G Marshall, Rachael A Lester, Michelle M Cancel, Alex R Paulsen, Laura E Bendzick, Raha A Been, Scott C Kogan, Robert T Cormier, Christina Kendziorski, David J Adams, Lara S Collier

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Analysis of tumor heterogeneity and cancer gene networks using deep sequencing of MMTV-induced mouse mammary tumors. by Christiaan Klijn, Marco J Koudijs, Jaap Kool, Jelle ten Hoeve, Mandy Boer, Joost de Moes, Waseem Akhtar, Martine van Miltenburg, Annabel Vendel-Zwaagstra, Marcel J T Reinders, David J Adams, Maarten van Lohuizen, John Hilkens, Lodewyk F A Wessels, Jos Jonkers

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HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation by Kevin B Myant, Patrizia Cammareri, Michael C Hodder, Jimi Wills, Alex Von Kriegsheim, Balázs Győrffy, Mamun Rashid, Simona Polo, Elena Maspero, Lynsey Vaughan, Basanta Gurung, Evan Barry, Angeliki Malliri, Fernando Camargo, David J Adams, Antonio Iavarone, Anna Lasorella, Owen J Sansom

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Knockout of SIN3B modulates transcriptional programs and cell survival in cutaneous melanoma by Larissa Satiko Alcantara Sekimoto Matsuyama, Victoria Harle, Victoria Offord, Alastair Droop, Roy Rabbie, Manik Garg, Martha Estefania Vázquez-Cruz, Carla Daniela Robles-Espinoza, Gemma Turner, David Fraser, Érica Aparecida de Oliveira, Danielle Gonçalves de Carvalho, Natasha Andressa Nogueira Jorge, Mariana Boroni, Patricia A. Possik, David J. Adams, Silvya Stuchi Maria-Engler

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Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene. by Simon Maguire, Jeanne Estabel, Neil Ingham, Selina Pearson, Edward Ryder, Damian M Carragher, Nicolas Walker, Sanger MGP Slc25a21 Project Team, James Bussell, Wai-In Chan, Thomas M Keane, David J Adams, Cheryl L Scudamore, Christopher J Lelliott, Ramiro Ramírez-Solis, Natasha A Karp, Karen P Steel, Jacqueline K White, Anna-Karin Gerdin

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Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome. by Rebecca E McIntyre, Pavithra Lakshminarasimhan Chavali, Ozama Ismail, Damian M Carragher, Gabriela Sanchez-Andrade, Josep V Forment, Beiyuan Fu, Martin Del Castillo Velasco-Herrera, Andrew Edwards, Louise van der Weyden, Fengtang Yang, Sanger Mouse Genetics Project, Ramiro Ramirez-Solis, Jeanne Estabel, Ferdia A Gallagher, Darren W Logan, Mark J Arends, Stephen H Tsang, Vinit B Mahajan, Cheryl L Scudamore, Jacqueline K White, Stephen P Jackson, Fanni Gergely, David J Adams

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Wnt/β-catenin activation by mutually exclusive FBXW11 and CTNNB1 hotspot mutations drives salivary basal cell adenoma by Kim Wong, Justin A. Bishop, Ilan Weinreb, Marialetizia Motta, Martin Del Castillo Velasco-Herrera, Emanuele Bellacchio, Ingrid Ferreira, Louise van der Weyden, Jacqueline M. Boccacino, Antonella Lauri, Giovannina Rotundo, Andrea Ciolfi, Saamin Cheema, Rebeca Olvera-León, Victoria Offord, Alastair Droop, Ian Vermes, Michael Allgäuer, Martin Hyrcza, Elizabeth Anderson, Katie Smith, Nicolas de Saint Aubain, Carolin Mogler, Albrecht Stenzinger, Mark J. Arends, Thomas Brenn, Marco Tartaglia, David J. Adams

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