A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology by Dag Sehlin, Sahar Roshanbin, Olof Zachrisson, Martin Ingelsson, Stina Syvänen

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Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody by Eva Schlein, Ken G. Andersson, Tiffany Dallas, Stina Syvänen, Dag Sehlin

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The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo by Gillian Bonvicini, Sunitha Singh, Lisa Sandersjöö, Dag Sehlin, Stina Syvänen, Ken G. Andersson

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Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β by Rebecca Faresjö, Elisabet O. Sjöström, Tiffany Dallas, Magnus M. Berglund, Jonas Eriksson, Dag Sehlin, Stina Syvänen

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Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration by Andrés de la Rosa, Nicole G. Metzendorf, Jonathan Efverström, Ana Godec, Dag Sehlin, Jamie Morrison, Greta Hultqvist

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High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose by Gillian Bonvicini, Sunitha Singh, Lisa Sandersjöö, Tiffany Dallas, Eva Schlein, Amelia D. Dahlén, Sara Lopes van den Broek, Dag Sehlin, Ken G. Andersson, Stina Syvänen

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Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery by Chiara Beretta, Abdulkhalek Dakhel, Khalid Eltom, Fredrik Rosqvist, Simon Uzoni, Tobias Mothes, John S. Fletcher, Ulf Risérus, Dag Sehlin, Jinar Rostami, Wojciech Piotr Michno, Anna Erlandsson

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Development of a toxin-selective immunotracer for in vivo detection of Clostridioides difficile infection by immunoPET by Mario González-Arjona, Lorena Cussó, Luis Alcalá, María Isabel González, Alexandra de Francisco, María Jesús Fernández-Aceñero, Dag Sehlin, Stina Syvänen, Emilio Bouza, Patricia Muñoz, Manuel Desco, Beatriz Salinas

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A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro by Inga Petersen, Jamie I. Morrison, Alex Petrovic, Neira Babic, Nicole G. Metzendorf, Ana Godec, Andrés de la Rosa, Fadi Rofo, Sina Bondza, Jos Buijs, Farahnaz Ranjbarian, Anders Hofer, Dag Sehlin, Greta Hultqvist

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