Christopher J. Schofield
Christopher Joseph Schofield (also known as Chris Schofield) is a Professor of Chemistry at the University of Oxford and a Fellow of the Royal Society. Chris Schofield is a professor of organic chemistry at the University of Oxford, Department of Chemistry and a Fellow of Hertford College. Schofield studied functional, structural and mechanistic understanding of enzymes that employ oxygen and 2-oxoglutarate as a co-substrate. His work has opened up new possibilities in antibiotic research, oxygen sensing, and gene regulation.After work on plant and microbial oxygenases, he studied uncharacterised human oxygenases. His research has identified unanticipated roles for oxygenases in regulating gene expression, importantly in the cellular hypoxic response, and has revealed new post-translational modifications to chromatin and RNA splicing proteins. The work has identified new opportunities for medicinal intervention. Provided by Wikipedia
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Human prolyl hydroxylase domain 2 reacts with O2 and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes by Giorgia Fiorini, Stephen A. Marshall, William D. Figg, William K. Myers, Lennart Brewitz, Christopher J. Schofield
Published 2024-10-01Get full text
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Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α). by Armin Thalhammer, Zuzana Bencokova, Rachel Poole, Christoph Loenarz, Julie Adam, Linda O'Flaherty, Johannes Schödel, David Mole, Konstantinos Giaslakiotis, Christopher J Schofield, Ester M Hammond, Peter J Ratcliffe, Patrick J Pollard
Published 2011-01-01Get full text
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Pharmacological inhibition of FTO. by Fiona McMurray, Marina Demetriades, WeiShen Aik, Myrte Merkestein, Holger Kramer, Daniel S Andrew, Cheryl L Scudamore, Tertius A Hough, Sara Wells, Frances M Ashcroft, Michael A McDonough, Christopher J Schofield, Roger D Cox
Published 2015-01-01Get full text
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Author Correction: Normal tissue radioprotection by amifostine via Warburg-type effects by Michael I. Koukourakis, Alexandra Giatromanolaki, Christos E. Zois, Dimitra Kalamida, Stamatia Pouliliou, Ilias V. Karagounis, Tzu-Lan Yeh, Martine I. Abboud, Timothy D. W. Claridge, Christopher J. Schofield, Efthimios Sivridis, Costantinos Simopoulos, Savvas P. Tokmakidis, Adrian L. Harris
Published 2025-02-01Get full text
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Normal tissue radioprotection by amifostine via Warburg-type effects by Michael I. Koukourakis, Alexandra Giatromanolaki, Christos E. Zois, Dimitra Kalamida, Stamatia Pouliliou, Ilias V. Karagounis, Tzu-Lan Yeh, Martine I. Abboud, Timothy D. W. Claridge, Christopher J. Schofield, Efthimios Sivridis, Costantinos Simopoulos, Savvas P. Tokmakidis, Adrian L. Harris
Published 2016-08-01Get full text
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Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. by Oliver N F King, Xuan Shirley Li, Masaaki Sakurai, Akane Kawamura, Nathan R Rose, Stanley S Ng, Amy M Quinn, Ganesha Rai, Bryan T Mott, Paul Beswick, Robert J Klose, Udo Oppermann, Ajit Jadhav, Tom D Heightman, David J Maloney, Christopher J Schofield, Anton Simeonov
Published 2010-11-01Get full text
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Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain. by Mun Chiang Chan, Onur Atasoylu, Emma Hodson, Anthony Tumber, Ivanhoe K H Leung, Rasheduzzaman Chowdhury, Verónica Gómez-Pérez, Marina Demetriades, Anna M Rydzik, James Holt-Martyn, Ya-Min Tian, Tammie Bishop, Timothy D W Claridge, Akane Kawamura, Christopher W Pugh, Peter J Ratcliffe, Christopher J Schofield
Published 2015-01-01Get full text
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Filamin C dimerisation is regulated by HSPB7 by Zihao Wang, Guodong Cao, Miranda P. Collier, Xingyu Qiu, Sophie Broadway-Stringer, Dominik Šaman, Jediael Z. Y. Ng, Navoneel Sen, Amar J. Azad, Charlotte Hooper, Johannes Zimmermann, Michael A. McDonough, Jürgen Brem, Patrick Rabe, Haigang Song, T. Reid Alderson, Christopher J. Schofield, Jani R. Bolla, Kristina Djinovic-Carugo, Dieter O. Fürst, Bettina Warscheid, Matteo T. Degiacomi, Timothy M. Allison, Georg K. A. Hochberg, Carol V. Robinson, Katja Gehmlich, Justin L. P. Benesch
Published 2025-05-01Get full text
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