A pivotal decade for bispecific antibodies? by Marlena Surowka, Christian Klein

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Hydrogen Bonds, Halogen Bonds, and Other Non-Covalent Interactions in a Series of Iodocymantrenes [Mn(C₅I<i>_n</i>H_5−<i>n</i>)(CO)₂L], L... by Christian Klein-Heßling, Karlheinz Sünkel

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The emerging landscape of novel 4-1BB (CD137) agonistic drugs for cancer immunotherapy by Christina Claus, Claudia Ferrara-Koller, Christian Klein

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Beyond checkpoint inhibition: PD-1 cis-targeting of an IL-2Rβγ-biased interleukin-2 variant as a novel approach to build on checkpoint inhibition by Laura Codarri Deak, Masao Hashimoto, Pablo Umaña, Christian Klein

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Mechanistic insights into resistance mechanisms to T cell engagers by Linlin Cao, Gabrielle Leclercq-Cohen, Christian Klein, Antonio Sorrentino, Marina Bacac

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Bluues_cplx: Electrostatics at Protein–Protein and Protein–Ligand Interfaces by Miguel Angel Soler, Rayyan Bassem Adel Yakout, Ozge Ozkilinc, Gennaro Esposito, Walter Rocchia, Christian Klein, Federico Fogolari

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Resolving the structural basis of therapeutic antibody function in cancer immunotherapy with RESI by Isabelle Pachmayr, Luciano A. Masullo, Susanne C. M. Reinhardt, Jisoo Kwon, Maite Llop, Ondřej Skořepa, Sylvia Herter, Marina Bacac, Christian Klein, Ralf Jungmann

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Combining chemotherapeutic agents and netrin‐1 interference potentiates cancer cell death by Andrea Paradisi, Marion Creveaux, Benjamin Gibert, Guillaume Devailly, Emeline Redoulez, David Neves, Elsa Cleyssac, Isabelle Treilleux, Christian Klein, Gerhard Niederfellner, Philippe A. Cassier, Agnès Bernet, Patrick Mehlen

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Chronic antigen stimulation in melanoma induces T cell exhaustion and limits efficacy of T cell bispecific therapies by Idil Hutter-Karakoc, Eleni Maria Varypataki, Aparna Neelakandhan, Simone Lang, Vesna Kramar, Ahmet Varol, Sasha Simons, Marine Richard, Mudita Pincha, Dario Venetz, Johannes Sam, Nicole Joller, Christian Münz, Pablo Umana, Christian Klein, Maria Amann

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T cell margination: investigating the detour of T cells following forimtamig treatment in humanized mice by Nils O’Brien, Joerg P.J. Mueller, Ann-Marie E. Bröske, Jan Attig, Franz Osl, Cylia Crisand, Ann-Katrin Wolf, Richard Rae, Stefanie Lechner, Thomas Pöschinger, Christian Klein, Pablo Umaña, Sara Colombetti, Andreas Beilhack, Jan Eckmann

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Obesity drives depot-specific vascular remodeling in male white adipose tissue by Sana S. Hasan, David John, Martina Rudnicki, Ibrahim AlZaim, Daniel Eberhard, Iris Moll, Jacqueline Taylor, Christian Klein, Maximilian von Heesen, Lena-Christin Conradi, Ralf H. Adams, Eckhard Lammert, Joanna Kalucka, Christiana Ruhrberg, Stefanie Dimmeler, Andreas Fischer

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Divergent response to radio-immunotherapy is defined by intrinsic features of the tumor microenvironment by Christian Klein, Maria Amann, Jacob Gadwa, Laurel B Darragh, Miles Piper, Diemmy Nguyen, Sana D Karam, Michael W Knitz, Justin Yu, Nicholas Olimpo, Sophia Corbo, Jessica I Beynor, Brooke Neupert, Alexander T Nguyen, Chloe Hodgson, Khalid NM Abdelazeem, Anthony Saviola, Laurene Pousse, Ali Bransi, Mudita Pincha

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Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases by Jörg T Regula, Peter Lundh von Leithner, Richard Foxton, Veluchamy A Barathi, Chui Ming Gemmy Cheung, Sai Bo Bo Tun, Yeo Sia Wey, Daiju Iwata, Miroslav Dostalek, Jörg Moelleken, Kay G Stubenrauch, Everson Nogoceke, Gabriella Widmer, Pamela Strassburger, Michael J Koss, Christian Klein, David T Shima, Guido Hartmann

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Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors by Alfred Zippelius, Petra Herzig, Pratiksha Gulati, Christian Klein, Marta Trüb, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Marina Natoli, Klas Hatje, Fabian Junker, Zhiwen Jiang, Iakov I Davydov, Markus Germann, Daniel Marbach, Adrian Zwick, Patrick Weber, Stefan Seeber, Lothar Tietze, Laura Codarri-Deak, Henry Kao

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Generation of chimeric antigen receptor T cells targeting p95HER2 in solid tumors by Macarena Román Alonso, Ariadna Grinyó-Escuer, Santiago Duro-Sánchez, Irene Rius-Ruiz, Marta Bort-Brusca, Marta Escorihuela, Susana Maqueda-Marcos, Sandra Pérez-Ramos, Judit Gago, Vanesa Nogales, Martín Espinosa-Bravo, Vicente Peg, Santiago Escrivá-de-Romaní, Laia Foradada, Laura Soucek, Irene Braña, Vladimir Galvao, Silvia Martín-Lluesma, Ekkehard Moessner, Christian Klein, Elena Garralda, Cristina Saura, Joaquín Arribas

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Preclinical B cell depletion and safety profile of a brain‐shuttled crystallizable fragment‐silenced CD20 antibody by Vanessa L. Schumacher, Solen Pichereau, Juliana Bessa, Juergen Bachl, Sylvia Herter, Felix C. Weber, Johannes Auer, Anja Kipar, Michael Winter, Martina Stirn, Michael B. Otteneder, Kevin Brady, Anne Eichinger‐Chapelon, Adrian Roth, Nadine Stokar‐Regenscheit, Nicole Clemann, Shanon Seger, Claudia Senn, Juliane Hönig, Cordula Jany, Elisa Di Lenarda, Alain C. Tissot, Christian Klein, H.‐Christian vonBüdingen, Robert Mader, Mohammed Ullah, Niels Janssen, Eduard Urich

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Impact of Spatial Soil and Climate Input Data Aggregation on Regional Yield Simulations. by Holger Hoffmann, Gang Zhao, Senthold Asseng, Marco Bindi, Christian Biernath, Julie Constantin, Elsa Coucheney, Rene Dechow, Luca Doro, Henrik Eckersten, Thomas Gaiser, Balázs Grosz, Florian Heinlein, Belay T Kassie, Kurt-Christian Kersebaum, Christian Klein, Matthias Kuhnert, Elisabet Lewan, Marco Moriondo, Claas Nendel, Eckart Priesack, Helene Raynal, Pier P Roggero, Reimund P Rötter, Stefan Siebert, Xenia Specka, Fulu Tao, Edmar Teixeira, Giacomo Trombi, Daniel Wallach, Lutz Weihermüller, Jagadeesh Yeluripati, Frank Ewert

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Dose escalation study of the HLA-A2-WT1 CD3 bispecific antibody RO7283420 in relapsed/refractory acute myeloid leukemia by Martin Hutchings, Koorosh Korfi, Pau Montesinos, Armando Santoro, Hsin-An Hou, Pilar Martinez-Sanchez, Susana Vives, Sara Galimberti, Tsai-Yun Chen, Marco Frigeni, Sylvain Garciaz, Olga Salamero Garcia, Su-Peng Yeh, Karen Yee, Jordi Esteve, Ashish Bajel, Shaun Fleming, Anne Catherine Bretz, Jan Attig, Min Sun, Sina Nassiri, Tobias Rutishauser, Christian Klein, Y. May Ma, Gabriel Schnetzler, Stephanie Vauleon, Huixin Yu, Teresa Barata, Muriel Richard, Silke Simon, Heather Hinton, Nino Keshelava, Marion Subklewe

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