T cell responses induced by adenoviral vectored vaccines can be adjuvanted by fusion of antigen to the oligomerization domain of C4b-binding protein. by Emily K Forbes, Simone C de Cassan, David Llewellyn, Sumi Biswas, Anna L Goodman, Matthew G Cottingham, Carole A Long, Richard J Pleass, Adrian V S Hill, Fergal Hill, Simon J Draper

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Vaccination with conserved regions of erythrocyte-binding antigens induces neutralizing antibodies against multiple strains of Plasmodium falciparum. by Julie Healer, Jennifer K Thompson, David T Riglar, Danny W Wilson, Yu-H C Chiu, Kazutoyo Miura, Lin Chen, Anthony N Hodder, Carole A Long, Diana S Hansen, Jake Baum, Alan F Cowman

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Transgene optimization, immunogenicity and in vitro efficacy of viral vectored vaccines expressing two alleles of Plasmodium falciparum AMA1. by Sumi Biswas, Matthew D J Dicks, Carole A Long, Edmond J Remarque, Loredana Siani, Stefano Colloca, Matthew G Cottingham, Anthony A Holder, Sarah C Gilbert, Adrian V S Hill, Simon J Draper

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Phase 1 trial of the Plasmodium falciparum blood stage vaccine MSP1(42)-C1/Alhydrogel with and without CPG 7909 in malaria naïve adults. by Ruth D Ellis, Laura B Martin, Donna Shaffer, Carole A Long, Kazutoyo Miura, Michael P Fay, David L Narum, Daming Zhu, Gregory E D Mullen, Siddhartha Mahanty, Louis H Miller, Anna P Durbin

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Immunogenicity of self-associated aggregates and chemically cross-linked conjugates of the 42 kDa Plasmodium falciparum merozoite surface protein-1. by Feng Qian, Karine Reiter, Yanling Zhang, Richard L Shimp, Vu Nguyen, Joan A Aebig, Kelly M Rausch, Daming Zhu, Lynn Lambert, Gregory E D Mullen, Laura B Martin, Carole A Long, Louis H Miller, David L Narum

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High Plasmodium falciparum longitudinal prevalence is associated with high multiclonality and reduced clinical malaria risk in a seasonal transmission area of Mali. by Yaw Adomako-Ankomah, Matthew S Chenoweth, Katelyn Durfee, Saibou Doumbia, Drissa Konate, Mory Doumbouya, Abdoul S Keita, Daria Nikolaeva, Gregory S Tullo, Jennifer M Anderson, Rick M Fairhurst, Rachel Daniels, Sarah K Volkman, Mahamadou Diakite, Kazutoyo Miura, Carole A Long

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Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens. by Andrew R Williams, Alexander D Douglas, Kazutoyo Miura, Joseph J Illingworth, Prateek Choudhary, Linda M Murungi, Julie M Furze, Ababacar Diouf, Olivo Miotto, Cécile Crosnier, Gavin J Wright, Dominic P Kwiatkowski, Rick M Fairhurst, Carole A Long, Simon J Draper

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Plasma uric acid levels correlate with inflammation and disease severity in Malian children with Plasmodium falciparum malaria. by Tatiana M Lopera-Mesa, Neida K Mita-Mendoza, Diana L van de Hoef, Saibou Doumbia, Drissa Konaté, Mory Doumbouya, Wenjuan Gu, Karim Traoré, Seidina A S Diakité, Alan T Remaley, Jennifer M Anderson, Ana Rodriguez, Michael P Fay, Carole A Long, Mahamadou Diakité, Rick M Fairhurst

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Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria. by Ivo M B Francischetti, Emile Gordon, Bruna Bizzarro, Nidhi Gera, Bruno B Andrade, Fabiano Oliveira, Dongying Ma, Teresa C F Assumpção, José M C Ribeiro, Mirna Pena, Chen-Feng Qi, Ababacar Diouf, Samuel E Moretz, Carole A Long, Hans C Ackerman, Susan K Pierce, Anderson Sá-Nunes, Michael Waisberg

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Pyrimidine Azepine Targets the Plasmodium bc1 Complex and Displays Multistage Antimalarial Activity by Juliana Calit, Surendra K. Prajapati, Ernest D. Benavente, Jessica E. Araújo, Bingbing Deng, Kazutoyo Miura, Yasmin Annunciato, Igor M. R. Moura, Miho Usui, Jansen F. Medeiros, Carolina H. Andrade, Sabrina Silva-Mendonça, Anton Simeonov, Richard T. Eastman, Carole A. Long, Maisa da Silva Araujo, Kim C. Williamson, Anna Caroline C. Aguiar, Daniel Y. Bargieri

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Phase Ia clinical evaluation of the safety and immunogenicity of the Plasmodium falciparum blood-stage antigen AMA1 in ChAd63 and MVA vaccine vectors. by Susanne H Sheehy, Christopher J A Duncan, Sean C Elias, Sumi Biswas, Katharine A Collins, Geraldine A O'Hara, Fenella D Halstead, Katie J Ewer, Tabitha Mahungu, Alexandra J Spencer, Kazutoyo Miura, Ian D Poulton, Matthew D J Dicks, Nick J Edwards, Eleanor Berrie, Sarah Moyle, Stefano Colloca, Riccardo Cortese, Katherine Gantlett, Carole A Long, Alison M Lawrie, Sarah C Gilbert, Tom Doherty, Alfredo Nicosia, Adrian V S Hill, Simon J Draper

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Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909. by Christopher J A Duncan, Susanne H Sheehy, Katie J Ewer, Alexander D Douglas, Katharine A Collins, Fenella D Halstead, Sean C Elias, Patrick J Lillie, Kelly Rausch, Joan Aebig, Kazutoyo Miura, Nick J Edwards, Ian D Poulton, Angela Hunt-Cooke, David W Porter, Fiona M Thompson, Ros Rowland, Simon J Draper, Sarah C Gilbert, Michael P Fay, Carole A Long, Daming Zhu, Yimin Wu, Laura B Martin, Charles F Anderson, Alison M Lawrie, Adrian V S Hill, Ruth D Ellis

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