Discovery of Palazestrant (OP-1250), a Potent and Orally Bioavailable Complete Estrogen Receptor Antagonist (CERAN) and Selective Estrogen Receptor Degrader (SERD) by Raymond A. Ng, Susanna Barratt, Alison Parisian, Gopinath S. Palanisamy, Samiron Phukan, Richard Sun, Brandon Robello, Guadalupe Peña, Judevin Sapugay, David Yeghikyan, Chenbo Wang, Samir Satish Kher, Srinivasan Thangathirupathy, Robert Millikin, Guijun Yu, Teruki Watanabe, Fei Zhou, Brian Rich, Alexis Duncan, Samuel E. Andersen, Reena Chawla, David R. Zak, Dirk A. Heerding, Brian R. Hearn, Geoffrey Greene, Cyrus L. Harmon, Leslie Hodges-Gallagher, Peter J. Kushner, Sean W. Fanning, David C. Myles

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