Application of causal forests to randomised controlled trial data to identify heterogeneous treatment effects: a case study by Eleanor Van Vogt, Anthony C. Gordon, Karla Diaz-Ordaz, Suzie Cro

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Investigating the safety of physical rehabilitation with critically ill patients receiving vasoactive drugs: An exploratory observational feasibility study. by Huw R Woodbridge, Caroline M Alexander, Stephen J Brett, David B Antcliffe, Ee Lyn Chan, Anthony C Gordon

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The effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Random... by Jarrod L. Thomas, Kirsty C. McGee, Anower Hossain, Gavin D. Perkins, Anthony C. Gordon, Duncan Young, Danny McAuley, Mervyn Singer, Ranjit Lall, Tina Kramaric, Janet M. Lord, Tony Whitehouse, Luis A. J. Mur, for the STRESS-L. collaborators

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Association between tocilizumab, sarilumab and all-cause mortality at 28 days in hospitalised patients with COVID-19: A network meta-analysis. by Peter J Godolphin, David J Fisher, Lindsay R Berry, Lennie P G Derde, Janet V Diaz, Anthony C Gordon, Elizabeth Lorenzi, John C Marshall, Srinivas Murthy, Manu Shankar-Hari, Jonathan A C Sterne, Jayne F Tierney, Claire L Vale

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Digital innovation in healthcare: quantifying the impact of digital sepsis screening tools on patient outcomes—a multi-site natural experiment by Sarah Tonkin-Crine, Graham Cooke, Anthony C Gordon, Anthony Gordon, Shashank Patil, Runa Lazzarino, Andrew Brent, Kate Honeyford, Céire E Costelloe, Anne Kinderlerer, John Welch, Peter Ghazal, Claire Burnett, Alf Timney, Andrew Jonathan Brent, Cerie Costelloe, Pippa Goodman Ben Glampson

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Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B Trial): protocol for a multicentre phase 3 pragmatic clinical and cost-effectiveness randomised... by John Norrie, Stephen Morris, Daniel Francis McAuley, Bronagh Blackwood, Paul Dark, Matt P Wise, Anthony C Gordon, Kalliopi Kydonaki, Timothy Simon Walsh, David Hope, Christopher Weir, Gavin Perkins, Nazir I Lone, Benedict Creagh-Brown, Julia Boyd, Michael Reade, Richard Anthony Parker, Leanne M Aitken, Valerie J Page, Alasdair MacLullich, Cathrine A McKenzie, Alix Macdonald, Annabel Giddings, Lydia Emerson, Robert Glen

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Building an international precision medicine platform trial for the acute respiratory distress syndrome (ARDS): an expert consensus project report by Kiran Reddy, Neil Aggarwal, Narges Alipanah-Lechner, Djillali Annane, David B Antcliffe, Daphne Babalis, J Kenneth Baillie, Abigail Beane, Lieuwe DJ Bos, Aidan Burrell, Carolyn S Calfee, Kiki Cano-Gamez, Victoria R Cornelius, Mary Cross, Emma Davenport, Lorenzo del Sorbo, Laura Esserman, Eddy Fan, Vito Fanelli, Niall D Ferguson, D Clark Files, Christoph Fisser, Shigeki Fujitani, Ewan C Goligher, Anthony C Gordon, Giacomo Grasselli, Fergus Hamilton, Rashan Haniffa, Andrea Haren, Daniel JR Harvey, Leanne M Hays, Anna Heath, Nicholas Heming, Susanne Herold, Tim Hicks, Nao Ichihara, Vinod Jaiswal, Jun Kataoka, Julian C Knight, Patrick R Lawler, Kathleen Liu, John C Marshall, David M Maslove, Michael A Matthay, Daniel F McAuley, Nuala J Meyer, Jonathan A Millar, Holger Müller-Redetzky, Alistair Nichol, John Norrie, Marlies Ostermann, Andrew Owen, Cecilia M O’Kane, Dhruv Parekh, Rachel Phillips, Duncan Richards, Bram Rochwerg, Anthony J Rostron, Hiroki Saito, Romit J Samanta, Vittorio Scaravilli, Wesley Self, Manu Shankar-Hari, A John Simpson, Pratik Sinha, Marry R Smit, Jonathan Stewart, B Taylor Thompson, István Vadász, Ed Waddingham, Steve Webb, Graham Wheeler, D Martin Witzenrath, Mark M Wurfel, Thomas R Martin

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Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials by Cathrine Axfors, Andreas M. Schmitt, Perrine Janiaud, Janneke van’t Hooft, Sherief Abd-Elsalam, Ehab F. Abdo, Benjamin S. Abella, Javed Akram, Ravi K. Amaravadi, Derek C. Angus, Yaseen M. Arabi, Shehnoor Azhar, Lindsey R. Baden, Arthur W. Baker, Leila Belkhir, Thomas Benfield, Marvin A. H. Berrevoets, Cheng-Pin Chen, Tsung-Chia Chen, Shu-Hsing Cheng, Chien-Yu Cheng, Wei-Sheng Chung, Yehuda Z. Cohen, Lisa N. Cowan, Olav Dalgard, Fernando F. de Almeida e Val, Marcus V. G. de Lacerda, Gisely C. de Melo, Lennie Derde, Vincent Dubee, Anissa Elfakir, Anthony C. Gordon, Carmen M. Hernandez-Cardenas, Thomas Hills, Andy I. M. Hoepelman, Yi-Wen Huang, Bruno Igau, Ronghua Jin, Felipe Jurado-Camacho, Khalid S. Khan, Peter G. Kremsner, Benno Kreuels, Cheng-Yu Kuo, Thuy Le, Yi-Chun Lin, Wu-Pu Lin, Tse-Hung Lin, Magnus Nakrem Lyngbakken, Colin McArthur, Bryan J. McVerry, Patricia Meza-Meneses, Wuelton M. Monteiro, Susan C. Morpeth, Ahmad Mourad, Mark J. Mulligan, Srinivas Murthy, Susanna Naggie, Shanti Narayanasamy, Alistair Nichol, Lewis A. Novack, Sean M. O’Brien, Nwora Lance Okeke, Léna Perez, Rogelio Perez-Padilla, Laurent Perrin, Arantxa Remigio-Luna, Norma E. Rivera-Martinez, Frank W. Rockhold, Sebastian Rodriguez-Llamazares, Robert Rolfe, Rossana Rosa, Helge Røsjø, Vanderson S. Sampaio, Todd B. Seto, Muhammad Shahzad, Shaimaa Soliman, Jason E. Stout, Ireri Thirion-Romero, Andrea B. Troxel, Ting-Yu Tseng, Nicholas A. Turner, Robert J. Ulrich, Stephen R. Walsh, Steve A. Webb, Jesper M. Weehuizen, Maria Velinova, Hon-Lai Wong, Rebekah Wrenn, Fernando G. Zampieri, Wu Zhong, David Moher, Steven N. Goodman, John P. A. Ioannidis, Lars G. Hemkens

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Using research to prepare for outbreaks of severe acute respiratory infection by Andrew Bentley, John Marshall, Allen C Cheng, Anthony G Charles, Jordi Rello, Li Yang Hsu, David J Wallace, Shidasp Siami, Cédric Bruel, Sotharith Bory, Mich Vann, Bunlor Teav, Leakhann Som, Mikko J Jarrvisalo, Anni Pulkkinen, Tero Ala-kokko, Sari Melto, Thomas DAIX, Francois Philippart, Marchalot Antoine, Kelly Tiercelet, BRUYERE Remi, Sedillot Nicholas, Taimon Fabienne, Raomi Bruyere, Xavier Forceville, Simon Erickson, Lewis Campbell, Ravikiran Sonawane, John Santamaria, Mark Kol, Jeff Powis, Richard Hall, Anne E McCarthy, Philippe Jouvet, Mary Anne Opavsky, Elaine Gilfoyle, Nataly Farshait, Dori-Ann Martin, Donald Griesdale, John Muscedere, Asgar Rishu, Wai Ching Sin, Wallace Chun Wai Ngai, Paul Young, Annette Forrest, Alex Kazemi, Seton Henderson, Troy Browne, Anusha Ganeshalingham, Rachael McConnochie, Jae Hwa Cho, Tai Sun Park, Yun Su Sim, Youjin Chang, Heung Bum Lee, Seung Yong Park, Wai Ming Chan, Won-Yeon Lee, Derek C Angus, H Rogier van Doorn, Nguyen Van Kinh, Nguyen Vu Trung, Meghan Prin, Theogene Twagirumugabe, Olivier Felix UMUHIRE, HABARUREMA Sylvain, Eman Al Qasim, Jean-Michel Heraud, Mihaja Raberahona, Joelinotahiana Hasina RABARISON, Santiago Perez Patrigeon, Alejandra Ramirez-Venegas, Javier Araujo Meléndez, M Lourdes Guerrero, Ivan Mambule, Otieno George Ochieng, Behzad Nadjm, Iris Wai Sum Li, Won-Il Choi, KOMURIAN-PRADEL Florence, Yaseen M Arabi, T Eoin West, Elisabeth D Riviello, Rachael Parke, AnnaneE Djillali, Robert Fowler, Srinivas Murthy, Alistair Nichol, Calum Semple, Maya George, Miia Valkonen, Colin McArthur, Gail Carson, Genevieve O'Neill, J Perren Cobb, Jake Dunning, Jean-Daniel Chiche, Jin-Won Huh, Julia GUILLEBAUD, Norosoa Razanazatovo, Juilett Wambura Otieno, Karen Green, Kathy Rowan, John Kenneth Baillie, Laura Merson, Michael D Christian, Moritoki Egi, Nahoko Shindo, Peter Horby, Raul Pardinaz-Solis, Sebastián Ugarte Ubiergo, Steve AR Webb, Timothy M Uyeki, Anthony C Gordon, David L Paterson, Dean Everett, Evangelos J Giamarellos-Bourboulis, Kajsa-Stina Longuere, David Maslove, Gloria Crowl, Theresa Pedutem Humber, Edward Ellazar Humber, Ilona Bahinskaya, Joan Osbourne-Townsend, Ingeborg Welters, Nadia Malik, T S Browne, Jennifer Goodson, Vinaya Mahesh

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