Anders Dale

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Anders Martin Dale is a prominent neuroscientist and professor of radiology, neurosciences, psychiatry, and cognitive science at the University of California, San Diego (UCSD), and is one of the world's leading developers of sophisticated computational neuroimaging techniques. He is the founding Director of the Center for Multimodal Imaging Genetics (CMIG) at UCSD.

Dale founded and initially developed the brain imaging analysis software FreeSurfer as a graduate student at UCSD. He later co-developed FreeSurfer at Massachusetts General Hospital/Harvard Medical School with Bruce Fischl. In addition to FreeSurfer, his major scientific contributions include developing: a) event related functional magnetic resonance imaging (fMRI) (with Randy Buckner at Harvard), b) an in vivo method to quantify the gray matter thickness of the cerebral cortex using MRI images (with Bruce Fischl at Harvard), c) an analysis platform to combine fMRI with magnetoencephalography (MEG), d) computational morphometry to automatically label brain regions using MRI scans (with Bruce Fischl at Harvard and Rahul Desikan and Ron Killiany at Boston University), and e) MRI-based methodologies to quantify longitudinal change in brain regions (with Dominic Holland at UCSD).

Since 2013, in collaboration with Ole Andreassen at the University of Oslo, and using GWAS summary statistics (p-values and odds ratios), Dale has developed and validated methods for evaluating genetic overlap (pleiotropy) across diseases and phenotypes. These genetic pleiotropy methods have provided valuable insights across a number of diseases and identified novel single nucleotide polymorphisms associated with increased risk for schizophrenia, bipolar disorder, Alzheimer's disease, Parkinson's disease, frontotemporal dementia, corticobasal degeneration, hypertension, hypercholesterolemia and coronary artery disease. In collaboration with Rahul Desikan and Chun Fan, Dale has developed a polygenic score for quantifying the 'personalized' risk for quantifying Alzheimer's disease age of onset. Provided by Wikipedia