Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice by Esther K. Wolthuis, Alexander P. J. Vlaar, Goda Choi, Joris J. T. H. Roelofs, Marcel Levi, Nicole P. Juffermans, Marcus J. Schultz

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Plasminogen Activator Inhibitor-Type I Gene Deficient Mice Show Reduced Influx of Neutrophils in Ventilator-Induced Lung Injury by Esther K. Wolthuis, Alexander P. J. Vlaar, Jorrit-Jan H. Hofstra, Joris J. T. H. Roelofs, Vivian de Waard, Nicole P. Juffermans, Marcus J. Schultz

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From intensive care monitors to cloud environments: a structured data pipeline for advanced clinical decision supportResearch in context by Sijm H. Noteboom, Eline Kho, Maria Galanty, Clara I. Sánchez, Frans C.P. ten Bookum, Denise P. Veelo, Alexander P.J. Vlaar, Björn J.P. van der Ster

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Inflammatory pathways in transfusion-associated circulatory overload by RoseAnn E. Vik, Esther B. Bulle, Wilmore C. Webley, Paul Visintainer, Samantha Ramirez, Peter St. Marie, Theresa Stec, Lynne O’Hearn, Chester Andrzejewski, Jr., Alexander P. J. Vlaar

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Discordance and bleeding in critically ill patients with COVID-19 receiving unfractionated heparin: A comparison between aPTT and anti-factor Xa activity level monitoring by Merijn C. Reuland, Thijs F. van Haaps, Pieter O.L.P. Broeren, Nick van Es, Claire E. Dijkslag-van der Laan, Alexander P.J. Vlaar, Michiel Coppens, Marcella C.A. Müller

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Cell-free hemoglobin is associated with microcirculatory perfusion disturbances and acute kidney injury in rats on extracorporeal membrane oxygenation by Carolien Volleman, Dionne P. C. Dubelaar, Philippa G. Phelp, Roselique Ibelings, Anita M. Tuip-de Boer, Chantal A. Polet, Walter M. van den Bergh, Alexander P. J. Vlaar, Charissa E. van den Brom

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Hemostatic conditions following autologous transfusion of fresh vs stored platelets in experimental endotoxemia: an open-label randomized controlled trial with healthy volunteers by Stefan F. van Wonderen, Floor L.F. van Baarle, Anita M. Tuip-de Boer, Chantal A. Polet, Robin van Bruggen, Christie Vermeulen, Thomas R.L. Klei, Chi M. Hau, Rienk Nieuwland, Cornelis van ’t Veer, Anna L. Peters, Sanne de Bruin, Alexander P.J. Vlaar, Bart J. Biemond, Marcella C.A. Müller

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A phase I trial evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenously administered low-anticoagulant heparin (M6229) in critically ill sepsis... by Niels van Mourik, Rombout B. E. van Amstel, Marleen A. Slim, Lonneke A. van Vught, Tom van der Poll, Joram Huckriede, Femke de Vries, Sjef J. de Kimpe, Raf Crabbé, Simone J. M. van Leeuwen, Peter F. Ekhart, Chris P. M. Reutelingsperger, Gerry A. F. Nicolaes, Alexander P. J. Vlaar, Marcella C. A. Müller

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ImmunoSep (Personalised Immunotherapy in Sepsis) international double-blind, double-dummy, placebo-controlled randomised clinical trial: study protocol by Peter Pickkers, Evangelos J Giamarellos-Bourboulis, Mihai G Netea, Michael Bauer, Mihaela Lupse, Frank Bloos, Tom van der Poll, W Joost Wiersinga, Thierry Calandra, Sylvain Meylan, Alexander P J Vlaar, Sebastian Weis, Marleen A Slim, Niels van Mourik, Marcella C A Müller, Antigone Kotsaki, Lonneke van Vught, Aline de Nooijer, Lieke Bakkerus, Nikolaos Antonakos

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Clinical Subtype Trajectories in Sepsis Patients Admitted to the ICU: A Secondary Analysis of an Observational Study by Marleen A. Slim, MD, Rombout B. E. van Amstel, MD, Marcella C.A. Müller, MD, PhD, Olaf L. Cremer, MD, PhD, Alexander P. J. Vlaar, MD, PhD, Tom van der Poll, MD, PhD, W. Joost Wiersinga, MD, PhD, Christopher W. Seymour, MD, MSc, Lonneke A. van Vught, MD, PhD, MARS Consortium

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Host Response Protein Biomarkers Indicative of Persistent Acute Kidney Injury in Critically Ill COVID-19 Patients by Thei S. Steenvoorden, MD, Koen C. de Kruijf, BSc, Brent Appelman, MD, Bas Moggre, MD, Lieuwe D. J. Bos, MD, PhD, Alexander P. J. Vlaar, MD, PhD, Reneé A. Douma, MD, PhD, Fabrice Uhel, MD, PhD, Jesper Kers, MD, PhD, Jetta J. Oppelaar, MD, Lonneke A. van Vught, MD, PhD, Martijn Beudel, MD, PhD, Paul W. G. Elbers, MD, PhD, W. Joost Wiersinga, MD, PhD, Tom van der Poll, MD, PhD, Liffert Vogt, MD, PhD, Hessel Peters-Sengers, PhD, on behalf of the Amsterdam UMC COVID-19 Biobank Study Group and the CovidPredict Study Group, Diederik van de Beek, Sanne de Bruin, Daisy Rusch, Suat Simsek, Kees Brinkman, Niels Gritters van den Oever, Joop van den Bergh, Hamza Moeniralam, N. Bokhizzou, Martijn de Kruif, Helen Leavis

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Regional comparison of efficacy and safety for vilobelimab in critically ill, invasively mechanically ventilated COVID-19 patients by Gernot Marx, Antoine Roquilly, Tobias Welte, Jean Dellamonica, Greet Hermans, Martin Witzenrath, Michael Bauer, Matthias Gründling, Ulrich Jaschinski, Robert Zerbib, Djillali Annane, Matthijs C Brouwer, Bruno Mourvillier, Jean Baptiste Lascarrou, Francis Schneider, Guillaume Thiéry, Diederik van de Beek, Carole Schwebel, Fabio S. Taccone, Luc Desmedt, Claire Dupuis, Pieter van Paassen, Michael Piagnerelli, Endry H T Lim, Sanne de Bruin, Simon Rückinger, Claus Thielert, Renfeng Guo, Bruce P Burnett, Camilla Chong, Niels C Riedemann, Alexander P Vlaar, Alexander P. J. Vlaar, Leo M. A. Heunks, Sanne de Bruin, Endry H. T. Lim, Matthijs C. Brouwer, Pieter R. Tuinman, José Francisco K. Saraiva, Suzana M. Lobo, Rodrigo Boldo, Jesus A. Simon-Campos, Alexander D. Cornet, Anastasia Grebenyuk, Johannes M. Engelbrecht, Murimisi Mukansi, Philippe G. Jorens, Korinna Pilz, Diederik van de Beek, Niels C. Riedemann, Pierre Bulpa, Marc Diltoer, Nikolaas De Neve, Antonio T. Freire, Felipe D. Pizzol, Anna Karolina Marinho, Victor H. Sato, Clovis Arns da Cunha, Mathilde Neuville, Jean Luc Diehl, Jean Paul Mira, Marc Berger, Klaus Matschke, Roberto Mercado-Longoria, Belinda Gomez Quintana, Jorge Alberto Zamudio-Lerma

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