The International Health Cohorts Consortium (IHCC) advances population health research and genomic discovery by John J. Connolly, Scott Sundseth, Grant M. Wood, Chisom Nwaneri, Geoffrey Ginsburg, Philip Awadalla, Michele Ramsay, Thomas Keane, Peter Goodhand, Adam S. Butterworth, Hakon Hakonarson

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Leucocyte telomere length and risk of type 2 diabetes mellitus: new prospective cohort study and literature-based meta-analysis. by Peter Willeit, Julia Raschenberger, Emma E Heydon, Sotirios Tsimikas, Margot Haun, Agnes Mayr, Siegfried Weger, Joseph L Witztum, Adam S Butterworth, Johann Willeit, Florian Kronenberg, Stefan Kiechl

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Metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease by Carles Foguet, Xilin Jiang, Scott C Ritchie, Elodie Persyn, Yu Xu, Chief Ben-Eghan, Henry J Taylor, Emanuele Di Angelantonio, John Danesh, Adam S Butterworth, Samuel A Lambert, Michael Inouye

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Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses. by Luanluan Sun, Lisa Pennells, Stephen Kaptoge, Christopher P Nelson, Scott C Ritchie, Gad Abraham, Matthew Arnold, Steven Bell, Thomas Bolton, Stephen Burgess, Frank Dudbridge, Qi Guo, Eleni Sofianopoulou, David Stevens, John R Thompson, Adam S Butterworth, Angela Wood, John Danesh, Nilesh J Samani, Michael Inouye, Emanuele Di Angelantonio

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Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases. by Ricardo C Ferreira, Daniel F Freitag, Antony J Cutler, Joanna M M Howson, Daniel B Rainbow, Deborah J Smyth, Stephen Kaptoge, Pamela Clarke, Charlotte Boreham, Richard M Coulson, Marcin L Pekalski, Wei-Min Chen, Suna Onengut-Gumuscu, Stephen S Rich, Adam S Butterworth, Anders Malarstig, John Danesh, John A Todd

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GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm. by Leonardo Bottolo, Marc Chadeau-Hyam, David I Hastie, Tanja Zeller, Benoit Liquet, Paul Newcombe, Loic Yengo, Philipp S Wild, Arne Schillert, Andreas Ziegler, Sune F Nielsen, Adam S Butterworth, Weang Kee Ho, Raphaële Castagné, Thomas Munzel, David Tregouet, Mario Falchi, François Cambien, Børge G Nordestgaard, Fredéric Fumeron, Anne Tybjærg-Hansen, Philippe Froguel, John Danesh, Enrico Petretto, Stefan Blankenberg, Laurence Tiret, Sylvia Richardson

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A nutritional biomarker score of the Mediterranean diet and incident type 2 diabetes: Integrated analysis of data from the MedLey randomised controlled trial and the EPIC-InterAct... by Jakub G Sobiecki, Fumiaki Imamura, Courtney R Davis, Stephen J Sharp, Albert Koulman, Jonathan M Hodgson, Marcela Guevara, Matthias B Schulze, Ju-Sheng Zheng, Claudia Agnoli, Catalina Bonet, Sandra M Colorado-Yohar, Guy Fagherazzi, Paul W Franks, Thomas E Gundersen, Franziska Jannasch, Rudolf Kaaks, Verena Katzke, Esther Molina-Montes, Peter M Nilsson, Domenico Palli, Salvatore Panico, Keren Papier, Olov Rolandsson, Carlotta Sacerdote, Anne Tjønneland, Tammy Y N Tong, Yvonne T van der Schouw, John Danesh, Adam S Butterworth, Elio Riboli, Karen J Murphy, Nicholas J Wareham, Nita G Forouhi

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The blood metabolome of incident kidney cancer: A case-control study nested within the MetKid consortium. by Florence Guida, Vanessa Y Tan, Laura J Corbin, Karl Smith-Byrne, Karine Alcala, Claudia Langenberg, Isobel D Stewart, Adam S Butterworth, Praveen Surendran, David Achaintre, Jerzy Adamski, Pilar Amiano, Manuela M Bergmann, Caroline J Bull, Christina C Dahm, Audrey Gicquiau, Graham G Giles, Marc J Gunter, Toomas Haller, Arnulf Langhammer, Tricia L Larose, Börje Ljungberg, Andres Metspalu, Roger L Milne, David C Muller, Therese H Nøst, Elin Pettersen Sørgjerd, Cornelia Prehn, Elio Riboli, Sabina Rinaldi, Joseph A Rothwell, Augustin Scalbert, Julie A Schmidt, Gianluca Severi, Sabina Sieri, Roel Vermeulen, Emma E Vincent, Melanie Waldenberger, Nicholas J Timpson, Mattias Johansson

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The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis. by Ju-Sheng Zheng, Jian'an Luan, Eleni Sofianopoulou, Stephen J Sharp, Felix R Day, Fumiaki Imamura, Thomas E Gundersen, Luca A Lotta, Ivonne Sluijs, Isobel D Stewart, Rupal L Shah, Yvonne T van der Schouw, Eleanor Wheeler, Eva Ardanaz, Heiner Boeing, Miren Dorronsoro, Christina C Dahm, Niki Dimou, Douae El-Fatouhi, Paul W Franks, Guy Fagherazzi, Sara Grioni, José María Huerta, Alicia K Heath, Louise Hansen, Mazda Jenab, Paula Jakszyn, Rudolf Kaaks, Tilman Kühn, Kay-Tee Khaw, Nasser Laouali, Giovanna Masala, Peter M Nilsson, Kim Overvad, Anja Olsen, Salvatore Panico, J Ramón Quirós, Olov Rolandsson, Miguel Rodríguez-Barranco, Carlotta Sacerdote, Annemieke M W Spijkerman, Tammy Y N Tong, Rosario Tumino, Konstantinos K Tsilidis, John Danesh, Elio Riboli, Adam S Butterworth, Claudia Langenberg, Nita G Forouhi, Nicholas J Wareham

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Novel loci and biomedical consequences of iron homoeostasis variation by Elias Allara, Steven Bell, Rebecca Smith, Spencer J. Keene, Dipender Gill, Liam Gaziano, Deisy Morselli Gysi, Feiyi Wang, Vinicius Tragante, Amy Mason, Savita Karthikeyan, R. Thomas Lumbers, Emmanuela Bonglack, Willem Ouwehand, David J. Roberts, Joseph Dowsett, Sisse Rye Ostrowski, Margit Hørup Larsen, Henrik Ullum, Ole Birger Pedersen, Søren Brunak, Karina Banasik, Christian Erikstrup, DBDS Genomic Consortium, Jonathan Mitchell, Christian Fuchsberger, Cristian Pattaro, Peter P. Pramstaller, Domenico Girelli, Mikko Arvas, Jarkko Toivonen, Sophie Molnos, Annette Peters, Ozren Polasek, Igor Rudan, Caroline Hayward, Ciara McDonnell, Nicola Pirastu, James F. Wilson, Katja van den Hurk, Franke Quee, Luigi Ferrucci, Stefania Bandinelli, Toshiko Tanaka, Giorgia Girotto, Maria Pina Concas, Alessandro Pecori, Niek Verweij, Pim van der Harst, Yordi J. van de Vegte, Lambertus A. Kiemeney, Fred C. Sweep, Tessel E. Galesloot, Patrick Sulem, Daniel Gudbjartsson, Egil Ferkingstad, FinnGen Consortium, Luc Djousse, Kelly Cho, Michael Inouye, Stephen Burgess, Beben Benyamin, Konrad Oexle, Dorine Swinkels, Kari Stefansson, Magnus Magnusson, Andrea Ganna, Michael Gaziano, Kerry Ivey, John Danesh, Alexandre Pereira, Angela M. Wood, Adam S. Butterworth, Emanuele Di Angelantonio

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Cohort profile: the BangladEsh Longitudinal Investigation of Emerging Vascular and nonvascular Events (BELIEVE) cohort study by Anisur Rahman, Stephen Sutton, Mahbubur Rahman, Jason Crawte, Tahmeed Ahmed, Md Saimul Islam, Aliya Naheed, Adam S Butterworth, Emanuele Di Angelantonio, Matthew Walker, John Danesh, Angela Wood, Sarah Hawkes, Sadika Akhter, Catherine Perry, Aytalina Azarova, Ruchira T Naved, Meerjady Sabrina Flora, Nusrat Khan, Rajiv Chowdhury, Sohel Reza Choudhury, Nusrat Jahan, Stephen Kaptoge, Md Zahidul Islam, Kaniz Fatema, Kim Robin van Daalen, Shammi Luhar, Roderic L Jones, Abbas Bhuiya, Md Khalequzzaman, Syed Shariful Islam, Henry Taylor, Shamima Akter, Simon Griffin, Khairul Islam, Salma Akter, Ruchira Tabassum Naved, Abdul Malik, Rubhana Raqib, Animesh Talukder, Richard Houghton, Tahmina Shirin, Lawrence King, Kamrun Nahar, Samantha Farrow, Giulia Loffreda, Samsad Rabbani Khan, Valerie Rhenius, Nahida Akter, Md Mostafa Monower, Sabina Akter, Mantaka Rahman, Lisa Pennells, Maria L C Iurilli, Md Taslim Uddin Miah, Khan Mohammad Thouhidur Rahman, Sharraf Samin, Kazi Nazmus Saqeeb, Ishrat Tasmin, Eleanor Farrow, Ank Michielsen, Sarah Spackman, Charlotte van Coeverden, James Ajioka, Khondker Abdul Abdul Awal, Evangelia Chatzidiakou, Jörg Feldmann, Richard Fenner, Tuhin Haque, Sirajul Islam, Kamrul Hasan Khan, Fazila-Tun-Nesa Malik, Olalekan Popoola, Nicholas Mascie Taylor, Md Alfazal Khan, Israt Akter, Laboni Akter, Shoriful Islam, Mohammad Kamruzzaman, Monalisa Moni, A H M Rezwan, K M Thouhidur Rahman, Monjeline Sultana, Jesmin Akhter, Ayasha Akter, Bakul Akter, Jharna Akter, Jesmin Akter, Juba Akter, Khadiza Akter, Khadija Akter, Lipi Akter, Maksuda Akter, Mousumi Akter, Mst Lovely Akter, Nasima Akter, Samima Akter, Sema Akter, Shahida Akter, Shahnaj Akter, Taslima Akter, A T M Zorjis Alam, Mahmuda Atique, Lutfa Begum, Mst Nazma Begum, Farjana Choudhury, Mitali Paul Chowdhury, Robin Reza Chowdhury, Mukul Rani Debnath, Nahid Ferdash, Naima Ferdous, Md Rakib Al Hasan, Khandaker Hashanuzzaman, Shamima Haq, Md Riazul Haque, Alamgir Hossain, Md Ibrahim, Shahi Israt Jahan, Israt Jahan Jarin, Zohora Pradhan Jonaki, Asik Kabir, Tonema Kader, Md Mostafa Kamal, Sayed Kamruzzaman, Sadik Fatima Kanon, Nazmul Karim, Shamsul Karim, Tanuja Khanom, Shamim Ara Khatun, Badrun Nahar Lorin, Mst Sirajum Manira, Farhana Jahan Mary, Kazi Dilruba Mita, Lipi Mitra, Basudeb Mollik, Sudipta Nargis, Nusrat Alam Nawmee, Esrat Zahan Nesa, Mahmuda Akter Nipa, Mehenaz Parvin, Sanjida Parvin, Shahnaj Parvin, Suraiya Parvin, Nayan Rabidash, Rulia Rahman, Madhabi Rani, Shahjalal Sarker, Smriti Sarker, Razia Sultana Shathi, Fatema Shelly, Ireen Sultana, Rovaiya Sultana, Israt Jahan Sumi, Sharmin Tamanna, Khadija Akter Topy, Umme Habiba Urmee, Suraya Yesmin, Julianne Halley, Charlotte van Coeverden, Mahmuda Akther Akhi, Asia Akter, Labony Akter, Ms Mili Akter, Mst Shamima Akter, Setu Akter, Tahmina Akter, Md Sabdar Ali, Mst Jesmin Ara, Edyta Bujnik, Apu Chandra Das, Many Das, Nurjahan Fatema, Md Riyad Hasan, Soniya Jannat, Mst Amena Khatun, Most Nurnahar Khatun, William Mossman, Robyn Murdoch, Zannaton Naeem, Evrikleia Ntasi, Silvia Alonso Rodriguez, Tripty Roy, Most Abida Sultana, Laryssa Amado, Tanya Braune, Eilidh Cowan, Steve Ellis, Ellie Farrow, Hannah Lombardi, Niko Ovenden, Tamara Sabri, Md Khalid Sultan, Jim Ajioka, Khondker Abdul Awal, Arul Baradi, Emanuele Di Angelantonio, Camilla Faidutti, Joerg Feldmann, Louise Hair, Sharifuddin Hasnat, Shahid Akhter Hossain, Md Mominul Islam, Shafiul Islam, Joe Lavallée, Fazila Tun-Nesa Malik, Nick Mascie-Taylor, Md Sirajul Islam, Laurie Savage, Sara Shazad, Lalitha Sundaram, Aloka Tulukdar, Kim Van Daalen, Tanvir Chowdhury, Nurul Huda, Samia Naz Isha, Riaz Hossain Khan, Aliva Salmeen, Zeeba Zahra Sultana

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Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure by Mahboube Ganji-Arjenaki, Zoha Kamali, Soroush Sardari, Martin de Borst, Harold Snieder, Ahmad Vaez, Evangelos Evangelou, Helen R. Warren, He Gao, Georgios Ntritsos, Niki Dimou, Tonu Esko, Reedik Mägi, Lili Milani, Peter Almgren, Thibaud Boutin, Stéphanie Debette, Jun Ding, Franco Giulianini, Elizabeth G. Holliday, Anne U. Jackson, Ruifang Li -Gao, Wei -Yu Lin, Jian'an Luan, Massimo Mangino, Christopher Oldmeadow, Bram Peter Prins, Yong Qian, Muralidharan Sargurupremraj, Nabi Shah, Praveen Surendran, Sébastien Thériault, Niek Verweij, Sara M. Willems, Jing -Hua Zhao, Philippe Amouyel, John Connell, Renée de Mutsert, Alex S.F. Doney, Martin Farrall, Cristina Menni, Andrew D. Morris, Raymond Noordam, Guillaume Paré, Neil R. Poulter, Denis C. Shields, Alice Stanton, Simon Thom, Gonçalo Abecasis, Najaf Amin, Dan E. Arking, Kristin L. Ayers, Caterina M. Barbieri, Chiara Batini, Joshua C. Bis, Tineka Blake, Murielle Bochud, Michael Boehnke, Eric Boerwinkle, Dorret I. Boomsma, Erwin P. Bottinger, Peter S. Braund, Marco Brumat, Archie Campbell, Harry Campbell, Aravinda Chakravarti, John C. Chambers, Ganesh Chauhan, Marina Ciullo, Massimiliano Cocca, Francis Collins, Heather J. Cordell, Gail Davies, Martin H. de Borst, Eco J. de Geus, Ian J. Deary, Joris Deelen, Fabiola Del Greco M, Cumhur Yusuf Demirkale, Marcus Dörr, Georg B. Ehret, Roberto Elosua, Stefan Enroth, A. Mesut Erzurumluoglu, Teresa Ferreira, Mattias Frånberg, Oscar H. Franco, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Christian Gieger, Giorgia Girotto, Anuj Goel, Alan J. Gow, Vilmundur Gudnason, Xiuqing Guo, Ulf Gyllensten, Anders Hamsten, Tamara B. Harris, Sarah E. Harris, Catharina A. Hartman, Aki S. Havulinna, Andrew A. Hicks, Edith Hofer, Albert Hofman, Jouke-Jan Hottenga, Jennifer E. Huffman, Shih-Jen Hwang, Erik Ingelsson, Alan James, Rick Jansen, Marjo -Riitta Jarvelin, Roby Joehanes, Åsa Johansson, Andrew D. Johnson, Peter K. Joshi, Pekka Jousilahti, J. Wouter Jukema, Antti Jula, Mika Kähönen, Sekar Kathiresan, Bernard D. Keavney, Kay-Tee Khaw, Paul Knekt, Joanne Knight, Ivana Kolcic, Jaspal S. Kooner, Seppo Koskinen, Kati Kristiansson, Zoltan Kutalik, Maris Laan, Marty Larson, Lenore J. Launer, Benjamin Lehne, Terho Lehtimäki, David C.M. Liewald, Li Lin, Lars Lind, Cecilia M. Lindgren, YongMei Liu, Ruth J.F. Loos, Lorna M. Lopez, Yingchang Lu, Leo-Pekka Lyytikäinen, Anubha Mahajan, Chrysovalanto Mamasoula, Jaume Marrugat, Jonathan Marten, Yuri Milaneschi, Anna Morgan, Andrew P. Morris, Alanna C. Morrison, Peter J. Munson, Mike A. Nalls, Priyanka Nandakumar, Christopher P. Nelson, Teemu Niiranen, Ilja M. Nolte, Teresa Nutile, Albertine J. Oldehinkel, Ben A. Oostra, Paul F. O'Reilly, Elin Org, Sandosh Padmanabhan, Walter Palmas, Aarno Palotie, Alison Pattie, Brenda W.J.H. Penninx, Markus Perola, Annette Peters, Ozren Polasek, Peter P. Pramstaller, Quang Tri Nguyen, Olli T. Raitakari, Rainer Rettig, Kenneth Rice, Paul M. Ridker, Janina S. Ried, Harriëtte Riese, Samuli Ripatti, Antonietta Robino, Lynda M. Rose, Jerome I. Rotter, Igor Rudan, Daniela Ruggiero, Yasaman Saba, Cinzia F. Sala, Veikko Salomaa, Nilesh J. Samani, Antti-Pekka Sarin, Reinhold Schmidt, Helena Schmidt, Nick Shrine, David Siscovick, Albert V. Smith, Harold Snieder, Siim Sõber, Rossella Sorice, John M. Starr, David J. Stott, David P. Strachan, Rona J. Strawbridge, Johan Sundström, Morris A. Swertz, Kent D. Taylor, Alexander Teumer, Martin D. Tobin, Maciej Tomaszewski, Daniela Toniolo, Michela Traglia, Stella Trompet, Jaakko Tuomilehto, Christophe Tzourio, André G. Uitterlinden, Ahmad Vaez, Peter J. van der Most, Cornelia M. van Duijn, Germaine C. Verwoert, Veronique Vitart, Uwe Völker, Peter Vollenweider, Dragana Vuckovic, Hugh Watkins, Sarah H. Wild, Gonneke Willemsen, James F. Wilson, Alan F. Wright, Jie Yao, Tatijana Zemunik, Weihua Zhang, John R. Attia, Adam S. Butterworth, Daniel I. Chasman, David Conen, Francesco Cucca, John Danesh, Caroline Hayward, Joanna M.M. Howson, Markku Laakso, Edward G. Lakatta, Claudia Langenberg, Olle Melander, Dennis O. Mook-Kanamori, Colin N.A. Palmer, Lorenz Risch, Robert A. Scott, Rodney J. Scott, Peter Sever, Tim D. Spector, Pim van der Harst, Nicholas J. Wareham, Eleftheria Zeggini, Daniel Levy, Patricia B. Munroe, Christopher Newton-Cheh, Morris J. Brown, Andres Metspalu, Bruce M. Psaty, Louise V. Wain, Paul Elliott, Mark J. Caulfield

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